Lifeboat Foundation

Faloon talking about the current state of the war on aging.

New research has revealed that fisetin – a natural flavonoid found in many fruits and vegetables – functions as an effective senolytic agent by clearing out damaged aging cells, improving health and extending lifespan.

Recently, we have shown that by administering the NAD+ precursor NMN (Nicotinamide Mononucleotide)in normal drinking water to older mice, NAD+ levels were restored to those normally associated with younger healthy animals. By administering NMN to mice for just one week, our lab demonstrated a robust correction in age-associated metabolic dysfunction and restored muscle mitochondrial function in old mice to levels seen in younger control mice (Gomes et al. 2013).

https://www.lifespan.io/campaigns/can-nmn-increase-longevity…019dfcda6c

Continue reading “Can supplementation with NMN Increase Longevity?” »

Dr. Aubrey De Grey, SENS Foundation, Co-Founder, talks of species that live hundreds of years. We have to understand metabolism and postpone old age.

How can reverse aging by improving repair mechanism. Cells die, and the waste as well as energy byproducts to avoid tissue breakdown with methyl donors.

Continue reading “Can we live long enough to live forever? Can we discover Immortality? Dr. Aubrey De Grey” »

The first of a series of info-nugget videos covering aging research. Today is a brief summary of aging.

For more aging research and news check out: https://www.leafscience.org/

Celebrate Unlimited Life Spans and a presentation by Bill Faloon on Human Age Reversal.
Bill Faloon will give an update on Age Reversal, similar to a presentation that he shared at RAAD Fest 2018!

Bill Faloon compiled the 1,500-page medical reference book Disease Prevention and Treatment, and his latest book is Pharmocracy: How Corrupt Deals and Misguided Medical Regulations Are Bankrupting America—and What to Do About It. He is also Director and Co-founder of the Life Extension Foundation.

Continue reading “Reversing Aging Update” »

Sometimes, people say that around 80 years of life will be enough for them, but have they thought it through?

When asked how long they want to live, people often say no more than ten years above their country’s average lifespan. This, mind you, is in a world where aging is still inevitable; people know they won’t be in top shape during those ten extra years, and yet, perhaps hoping they might be an exception to that rule, they still wish they could get that little extra time. Even when told that they will live these extra years in complete health, the most common choice is the current maximum recorded human lifespan, which is roughly 120 years.

If we assume that no rejuvenation therapies are available to extend the time you spend in youthful health, then it is somewhat understandable if you don’t feel up for a very long life, because the odds are that its final decades will be increasingly miserable ; however, if rejuvenation therapies were available, and you could be fully healthy for an indefinite time, why stop at 120 years? Life extension advocates have probably all had their fair share of conversations with people who insist that 80-odd years will be more than enough for them, health or no health—worse still, some don’t care about preserving their health precisely because they think that 80 years is a sufficiently long time to live.

Continue reading “Are You Sure Eighty Years Are Enough?” »

Today, we want to bring your attention to a recent mouse study on fisetin, a commonly available supplement that has proven effective at destroying senescent cells.

What are senescent cells?

As we age, increasing amounts of our cells enter into a state known as senescence. Normally, these cells destroy themselves by a self-destruct process known as apoptosis and are disposed of by the immune system. Unfortunately, as we age, the immune system declines, and increasing numbers of senescent cells escape apoptosis and accumulate in the body.

Previous research published earlier this year in Nature Medicine involving University of Minnesota Medical School faculty Paul D. Robbins and Laura J. Niedernhofer and Mayo Clinic investigators James L. Kirkland and Tamara Tchkonia, showed it was possible to reduce the burden of damaged cells, termed senescent cells, and extend lifespan and improve health, even when treatment was initiated late in life. They now have shown that treatment of aged mice with the natural product Fisetin, found in many fruits and vegetables, also has significant positive effects on health and lifespan.