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Category: life extension – Page 456

Life-long epigenetic programming of cortical architecture

The evolution of human diets led to preferences toward polyunsaturated fatty acid (PUFA) content with ‘Western’ diets enriched in ω-6 PUFAs. Mounting evidence points to ω-6 PUFA excess limiting metabolic and cognitive processes that define longevity in humans. When chosen during pregnancy, ω-6 PUFA-enriched ‘Western’ diets can reprogram maternal bodily metabolism with maternal nutrient supply precipitating the body-wide imprinting of molecular and cellular adaptations at the level of long-range intercellular signaling networks in the unborn fetus. Even though unfavorable neurological outcomes are amongst the most common complications of intrauterine ω-6 PUFA excess, cellular underpinnings of life-long modifications to brain architecture remain unknown. Here, we show that nutritional ω-6 PUFA-derived endocannabinoids desensitize CB1 cannabinoid receptors, thus inducing epigenetic repression of transcriptional regulatory networks controlling neuronal differentiation. We found that cortical neurons lose their positional identity and axonal selectivity when mouse fetuses are exposed to excess ω-6 PUFAs in utero. Conversion of ω-6 PUFAs into endocannabinoids disrupted the temporal precision of signaling at neuronal CB1 cannabinoid receptors, chiefly deregulating Stat3-dependent transcriptional cascades otherwise required to execute neuronal differentiation programs. Global proteomics identified the immunoglobulin family of cell adhesion molecules (IgCAMs) as direct substrates, with DNA methylation and chromatin accessibility profiling uncovering epigenetic reprogramming at 1400 sites in neurons after prolonged cannabinoid exposure. We found anxiety and depression-like behavioral traits to manifest in adult offspring, which is consistent with genetic models of reduced IgCAM expression, to suggest causality for cortical wiring defects. Overall, our data uncover a regulatory mechanism whose disruption by maternal food choices could limit an offspring’s brain function for life.

  • Immediate Communication
  • Published: 18 November 2019
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Cryonics: Ambulance To The Future?

Ira Pastor ideaXme exponential health ambassador interviews Mr. Dennis Kowalski, Cryonics Institute President, EMT-paramedic, certified in advanced cardiac life support (ACLS), advanced pediatric life support (PALS), a CPR Instructor for the American Heart Association, and a fire fighter!

Ira Pastor comments: Cryonics is defined as the extremely low-temperature freezing (or vitrification — converting into glass or a glass-like substance) usually at −196 °C or −320.8 °F or 77.1 K, and storage of a human body or part of a human body, with the hope that resurrection may be possible in the future.

Cryonics procedures can legally begin only after clinical death, and cryonics “patients” are legally dead. Cryonics procedures ideally begin within minutes of death, and use cryo-protectants to prevent ice formation during cryo-preservation The first person to be frozen via cryonics was that of Dr. James Bedford in 1967.

It’s estimated that over 300 bodies had been cryo-preserved in the United States, and a couple thousand people have made arrangements for cryo-preservation to date.

While it is not yet possible for a dead body to be re-animated after undergoing vitrification, in order to revive patients in the future, it will be necessary to be able to cure any diseases which lead to death, repair cells damaged in the freezing process, and repair cells damaged by the ageing process.

The Cryonics Institute (CI) is an American not-for-profit corporation that provides cryonics services to both humans and pets.

Continue reading “Cryonics: Ambulance To The Future?” | >

‘Transhumanist’ eternal life? No thanks, I’d rather learn not to fear death

While the transhumanism movement is making progress, it isn’t without its skeptics. Some don’t think it will ever work the way we want it to, because it asks science to turn back a natural process of aging that has an uncountable number of manifestations. Critics of anti-aging research envision any number of dystopian futures, in which we defeat many of the causes of death before very old age, leaving only the most ghastly and intractable — but not directly lethal — maladies.

Lest you think this concept is limited to snake-oil salesmen and science-fiction writers, the idea that aging is not inevitable is now in the mainstream of modern medical research at major institutions around the world. The journal Nature dubbed research from the University of California at Los Angeles a “hint that the body’s ‘biological age’ can be reversed.” According to reporting by Scientific American on research at the Salk Institute for Biological Studies: “Aging Is Reversible — at Least in Human Cells and Live Mice.”

Bacteria in the gut may alter aging process, study finds

This could be happening to me.

An international research team led by Nanyang Technological University, Singapore (NTU Singapore) has found that microorganisms living in the gut may alter the aging process, which could lead to the development of food-based treatment to slow it down.

All , including human beings, coexist with a myriad of microbial species living in and on them, and research conducted over the last 20 years has established their important role in nutrition, physiology, metabolism and behavior.

Using , the team led by Professor Sven Pettersson from the NTU Lee Kong Chian School of Medicine, transplanted gut microbes from (24 months old) into young, germ-free mice (six weeks old). After eight weeks, the had increased intestinal growth and production of neurons in the brain, known as neurogenesis.

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