Lifeboat Foundation

Besides healing wounds, this technique could be useful for repairing skin damage, countering the effects of aging, and better understanding skin cancer.

In the vicissitudes of life, our recent and living generations moved from the hard times of a hundred years ago to the exponential good times of today. Now a few hundred key pioneers have positioned the world in front of the opportunities of Transhumanism and its main tenet, indefinite life extension. Will we unite the world on these issues and capitalize or waste it and let the weeds reclaim our “wheel”, the magnum opus of our generations? I challenge all would-be leaders and followers to honor our ancestors’ long tradition of pioneering the next stages of our future. Everything about you was crafted and honed for this and there is no other time. Find the blazers of our emerging values and paths, your philosophers of the future, out there at the forefronts on this epic new transhuman voyage of freedoms and discoveries and follow them. All leaders who haven’t already, I implore you to fully embrace your roles, triple down and raise your flags even higher. Friedrich Nietzsche wrote a book preluding this philosophy of the future, which serves as the structure for this paper and is quoted here throughout.

“[Conditioning to hard times] is thus established, unaffected by the vicissitudes of generations; the constant struggle with uniform unfavourable conditions is, as already remarked, the cause of a type becoming stable and hard. Finally, however, a happy state of things results, the enormous tension is relaxed; there are perhaps no more enemies among the neighbouring peoples, and the means of life, even of the enjoyment of life, are present in superabundance. With one stroke the bond and constraint of the old discipline severs: it is no longer regarded as necessary, as a condition of existence—if it would continue, it can only do so as a form of luxury, as an archaizing taste. Variations, whether they be deviations (into the higher, finer, and rarer), or deteriorations and monstrosities, appear suddenly on the scene in the greatest exuberance and splendour; the individual dares to be individual and detach himself. At this turning-point of history there manifest themselves, side by side, and often mixed and entangled together, a magnificent, manifold, virgin-forest-like up-growth and up-striving, a kind of tropical tempo in the rivalry of growth, and an extraordinary decay and self-destruction, owing to the savagely opposing and seemingly exploding aptitudes, which strive with one another ‘for sun and light,’ and can no longer assign any limit, restraint, or forbearance for themselves by means of the hitherto existing morality. It was this morality itself which piled up the strength so enormously, which bent the bow in so threatening a manner:—it is now ‘out of date,’ it is getting ‘out of date.’ ” – Friedrich Nietzsche, Beyond Good and Evil: Prelude to a Philosophy of the Future

Our elders came from the great depression and world war. Then they had to watch what they called “morals”, but which were actually just coping mechanisms particular to their vicissitude of time, as Nietzsche gets at in various places, become increasingly disregarded. That happened faster than ever because, little did they know, the bell curve of exponential advancements in fields across the board were upon them. The variations of excellence and monstrosities proliferated like no other time and were supercharged for an abundant harvest by the buds of enlightenment and technology that had been poking their heads out of the fertile intellectual fields of civilization from the smatterings of good times they were able to come upon throughout the century. A lot of it was stored as compounding action potential. It went off like rifles in the 50s and 60s, with so much force that the bullets are still flying today, and the shots of individual aptitude have been firing ever since. Like he is saying, it’s a jungle of individual morals competing in the survival of the fittest, so you must find ways, that hard times naturally make, to get all these independent construction workers of the best ideas behind the same projects in order to tap that energy for the big stages and human potentials.

This is our window in time here, as I often say, to get projects like life extension, transhumanism, space exploration, and some other things done. The people of the past didn’t have this opportunity and the chance here isn’t available forever because death will close us off from it or bad times will set back in. A great gate in Plato’s cave has opened, the eternal guard lions of death have left their posts and we don’t know how long until they come back or the gate closes. It is devastating watching those who have been hypnotized by the cave, by the death trance, sitting there with a wide-open door and the clock ticking down. The climb must be made, now is the time, there is no other. Team up and follow the leaders on these new emerging circumstances and moral imperatives or everyone will die as the marvels of space and boundless technology tumble from our hands. We rouse them to action slowly but surely, though all as one, more gets done.

Continue reading “Notes from Nietzsche and some Correlations with Transhumanism” »

Rejuvenation challenges the status quo, but that’s only good.

One of the reasons why the idea of rejuvenating people isn’t all that easy to sell is that it challenges the status quo. For good or bad, we’re used to the fact that our health goes south on us as time goes by, ultimately killing us if nothing else does.

That’s not a nice certainty to have, but our species is one of planners; we tend to prefer bad certainties to uncertainty. For example, some people want to be certain that, at some point, they won’t be fit for work anymore and will need to retire; they prefer this over the uncertainty of not knowing how they’d make a living at age 150.

Continue reading “The Status Quo of Aging” »

Researchers have found a way to short-circuit the “immortality switch” that cancer cells use to divide indefinitely.

He says this has been done successfully with mice. They have mice live twice as long. They are testing aging reversal in dogs in 2018–2019. Human treatments could be available on a general basis by 2025.

George Church is developing better and better organs using pigs. They are working to slow or reverse the aging in the organs to be used for transplant.

Continue reading “George Church talks about reversing human aging and claims they made mice live twice as long” »

Research has shed new light on genetic processes that may one day lead to the development of therapies that can slow, or even reverse, how our cells age.

A study led by the University of Exeter Medical School has found that certain genes and pathways that regulate splicing factors – a group of proteins in our body that tell our genes how to behave—play a key role in the ageing process. Significantly, the team found that disrupting these genetic processes could reverse signs of ageing in cells.

The study, published in the FASEB Journal, was conducted in human cells in laboratories. Aged, or senescent, cells are thought to represent a driver of the ageing process and other groups have shown that if such cells are removed in animal models, many features of ageing can be corrected. This new work from the Exeter team found that stopping the activity of the pathways ERK and AKT, which communicate signals from outside the cell to the genes, reduced the number of senescent cells in in cultures grown in the laboratory. Furthermore, they found the same effects from knocking out the activity of just two genes controlled by these pathways—FOX01 and ETV6.

Continue reading “Disrupting genetic processes reverses ageing in human cells” »

A wonderfully written, very friendly essay on the discoveries, carrier and life of Prof Dr David Sinclair and of course on sirtuins, the epigenetic theory of aging, resveratrol, nicotinamide dinucleotide NAD+ and healthy aging.

Since my recent visit to the Harvard Medical School laboratory run by Australian geneticist David Sinclair, I’ve been struggling with a shamefully greedy impulse. How can I get my hands on the wonder molecules that Sinclair is trialling to amazing effect in mice, not only slowing down their ageing but reversing it? My fear of missing out has flared up since I learnt from Sinclair that he estimates at least a third of his scientific colleagues are taking some version of these “anti-ageing” molecules, just as he does, in the belief it will increase their health spans by as much as 10 years. This means not just having a chance at living an extra decade, but living it in good health, avoiding the age-related diseases and general frailty that can make those years harrowing.

It becomes difficult to remain impartial when a respected scientist tells you he will soon turn 50, does not have a single grey hair and, according to regular blood and genetic tests, has the biological age of 31.4, even though he’s a workaholic and doesn’t exercise much. Or that he likes to think his mother prolonged her life – post lung cancer, with only one lung – for 20 years by taking the molecules he gave her, and that his 79-year-old father, who has taken several different kinds of them for years, currently lists whitewater rafting and mountaineering among his hobbies. Sinclair’s wife, Sandra Luikenhuis, even gives these molecules to the family dogs. (Luikenhuis, who has a PhD in genetics from Massachusetts Institute of Technology, only began taking the molecules herself after she noticed the irrefutably positive effect they’d had on their pets.)

Continue reading “Can David Sinclair cure old age?” »

It has recently been suggested that humans could live to 150 by 2020 simply by taking a certain supplement.

A wide panel discussion on the anti aging biotechnology is taking place now. I will mention only the important lecture on senescent cells, aging and drugs given this afternoon by Dr Judith Campisi (Buck Institute for research on Aging), the small big woman scientist!