Lifeboat Foundation

https://paper.li/e-1437691924#/

Descartes once described the human body as a “fleshy machine” and today’s transhumanists would likely agree.

Philosopher Nick Bostrom writes that as we seek to peer farther into posthumanity our ability to concretely imagine what it might be like trails offend that the very essence of posthumanity is to be able to have thoughts and experiences that we cannot readily think or experience with our current capacities.

Continue reading “The Augmented Posthuman Body” »

Happy to announce our support for Elevian together with BOLD Capital and Peter Diamandis.

Commercializing scientific breakthroughs from Elevian’s scientific co-founders.

Continue reading “Elevian Launches to Develop Regenerative Medicines for Age-Related Diseases” »

ATLANTA—A molecule produced during fasting or calorie restriction has anti-aging effects on the vascular system, which could reduce the occurrence and severity of human diseases related to blood vessels, such as cardiovascular disease, according to a study led by Georgia State University.

“As people become older, they are more susceptible to disease, like cancer, cardiovascular disease and Alzheimer’s disease,” said Dr. Ming-Hui Zou, senior author of the study, director of the Center for Molecular and Translational Medicine at Georgia State and a Georgia Research Alliance Eminent Scholar in Molecular Medicine. “Age is the most important so-called risk factor for human disease. How to actually delay aging is a major pathway to reducing the incident and severity of human disease.

”The most important part of aging is vascular aging. When people become older, the vessels that supply different organs are the most sensitive and more subject to aging damage, so studying vascular aging is very important. This study is focused on vascular aging, and in old age, what kind of changes happen and how to prevent vascular aging.”

Continue reading “Researchers Identify Molecule With Anti-Aging Effects On Vascular System” »

From the perspective of critics, there are many reasons to be concerned about the rise of artificial intelligence.

Billionaire inventor Elon Musk — perhaps the world’s most vocal AI antagonist — has warned that the technology could become “an immortal dictator from which we would never escape.”

Several years before his death, Stephen Hawking, the renowned theoretical physicist, said artificial intelligence could bypass biological evolution, leaving humans unable to compete.

Continue reading “Prince Charles Says He ‘Utterly Objects’ to The Idea of People Becoming Part Human, Part Machine” »

Today, we are going to take a look at the topic of NAD+, its precursor, nicotinamide mononucleotide, and the debate surrounding the ability of these molecules to pass through the cell membrane.

NAD+ is critical for cellular function

Nicotinamide adenine dinucleotide (NAD+) is a redox cofactor, but it is also a critical signaling molecule that regulates cell function and survival in response to environmental changes such as nutrient intake and cellular damage. Age-related changes to the level of NAD+ in the cell impacts mitochondrial function, nutrient sensing and metabolism, redox reactions, circadian rhythm, immune and inflammatory responses, DNA repair, cell division, protein-to-protein signaling, chromatin, and epigenetics.

An interesting article in Forbes on GDF11, anti-aging drugs and companies:

For an example of how hard it is to develop an anti-aging medicine, check this out. It’s some of the coolest and creepiest science to have been published in major academic journals. But is it ready to form the basis of a pharmaceutical company?

I know 100 leaders in longevity area. All of them will be invited to the Longevity Impact Forum, to create sort of Alibaba of longevity. We can beat government agencies and big companies because of our spirit!

“Underdog” entrepreneur Jack Ma is now famous for his record setting IPO when he took his e-commerce company, Alibaba, public. But not many people know he started Alibaba in his one-room apartment with 17 friends. Watch where all the magic of Alibaba started and be sure to check out Jack Ma’s amazing life.

David Gobel was the first to put forward the concept of longevity escape velocity, or LEV. How far are we from LEV, assuming the current pace of research and no serious showstoppers?

Twelve years, or 2030, is David’s best guess based on what is known today.

David Gobel cofounded the Methuselah Foundation with Aubrey de Grey and continues to run the Methuselah Foundation today.

Continue reading “Methuselah Foundation Cofounder thinks Longevity Escape Velocity could be here by 2030” »

What does it feel like when you know your doctor can’t really help you?

Some time ago, I noticed a stock photo of an old lady seeing her geriatrician, who was a much younger woman. Nothing special was happening in the picture, which showed just two people talking; however, it made me wonder what it must feel like to be an elderly person consulting a geriatrician.

One initial assumption could be that it isn’t much different than seeing a GP, but that seems unlikely. If you are seeing a GP, the odds are your disease or ailment is not debilitating, let alone life-threatening. Whatever it might be, you went to see your doctor knowing that, most likely, he or she would be able to cure you; especially if you are young, it’s probable that just taking a medicine for some time, or doing physical therapy, will make you better. You know that you will recover, and the discomfort or the suffering you’re going through is destined to go away. You will get back to your life as it used to be, healthy as ever.

Continue reading “From Within Your Own Failing Shell” »