Lifeboat Foundation

http://www.ivoox.com/programa-4x8-inmortalidad-gran-desafio-…454_1.html

Summary: Google’s ultra-secretive Calico Labs announces a significant discovery – the naked mole rat is the first and only non-aging mammal and shows little signs of aging as it gets older. [This article first appeared on the website LongevityFacts.com. Author: Brady Hartman. ]

With wrinkly skin and completely bald, the naked mole rat is one of the ugliest creatures around but lives an exceptionally long life for a small mammal. It rarely develops the chronic diseases of aging such as cancer and lives 10 times longer than regular rats.

The First Non-Aging Mammal

Continue reading “Google’s Calico Labs announces a new discovery: ‘a non-aging mammal.’” »

https://www.intouchrugby.com/magazine/feature-diet-nutrition…re-part-1/

https://player.fm/series/best-damn-podcast/interview-w-ira-p…generation

https://player.fm/series/caring-for-aging-parents/reversing-…ira-pastor

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New extensive study shares recent discoveries and sheds light on the role of telomere length in human diseases and aging. Part 3 of 3.

Newly published research reports on the accuracy of telomere length as a biomarker of aging, and its role in maximum human lifespan.

New research reports on the accuracy of telomere length as a biomarker of aging, and its role in maximum human lifespan. Part 1 of 3.

Dr. West keynoted at the very first SENS conference, back in 2003 in Cambridge, and it’s a true delight…

In a new study, researchers propose that TIGIT is a marker of T cell senescence and exhaustion in the immune system. However, not only is TIGIT just a biomarker, it is also a potential therapeutic target; as the researcher team discovered, lowering levels of TIGIT resulted in the restoration of some lost function in T cell populations that were experiencing high levels of senescence and exhaustion.

In a new study, researchers propose that TIGIT is a marker of T cell senescence and exhaustion in the immune system[1]. However, not only is TIGIT just a biomarker, it is also a potential therapeutic target; as the researcher team discovered, lowering levels of TIGIT resulted in the restoration of some lost function in T cell populations that were experiencing high levels of senescence and exhaustion.

Aging is associated with immune dysfunction, especially T-cell defects, which result in increased susceptibility to various diseases. Previous studies showed that T cells from aged mice express multiple inhibitory receptors, providing evidence of the relationship between T-cell exhaustion and T-cell senescence. In this study, we showed that T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain (TIGIT), a novel co-inhibitory receptor, was upregulated in CD8 + T cells of elderly adults. Aged TIGIT + CD8 + T cells expressed high levels of other inhibitory receptors including PD-1 and exhibited features of exhaustion such as downregulation of the key costimulatory receptor CD28, representative intrinsic transcriptional regulation, low production of cytokines, and high susceptibility to apoptosis. Importantly, their functional defects associated with aging were reversed by TIGIT knockdown.