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Category: life extension – Page 499

Jan Gruber – Looking at synergistic effects in longevity therapies

And his team at Yale-NUS have recently completed a detailed set of studies looking at eleven of the most promising anti-aging single drugs, using nematode worms (C. elegans) as their model organism.

Drug synergy found to increase lifespan in worms

Even though testing the effects of single drugs on health and longevity in various organisms is challenging by itself, and testing multiple drugs and their synergistic effects can be a logistical and statistical nightmare, they found some surprising results, including up to a 96 percent increase in lifespan [1]. As they conclude in their new paper:

LEAF at the Eurosymposium on Healthy Ageing

The Fourth Eurosymposium on Healthy Ageing (EHA) was held in Brussels on November 8–10, 2018, and we had the opportunity to give talks about aging, advocacy, and engaging new audiences.

The EHA is a conference hosted every two years by Heales, and it sees like-minded people from the research and advocacy community come together to share knowledge and listen to talks from various researchers and other experts in the field. We were very pleased to be invited to give two presentations during the conference and share our knowledge and experience with the audience there.

LEAF staff writer Nicola Bagalà gave a talk about the social issues relating to rejuvenation biotechnology, including the global need for longer, healthier lives, reasons for public skepticism, and the common pitfalls of advocacy.

Valery Novoselov: Investigating Jeanne Calment’s Longevity Record

Questions have been raised recently regarding Jeanne Calment’s record as the oldest recorded human.

If you open an article dedicated to supercentenarians, it is very likely that at its very beginning, you will see the name of Jeanne Calment, the oldest known person in the world, who is believed to have lived for up to 122 years. Jeanne is not merely a unique phenomenon from the point of view of statistics; over the years, she became a symbol of extraordinary human capacities.

For a person who sticks to a healthy lifestyle or even engages in biohacking in order to live longer, Jeanne’s record is a teasing goal to achieve and surpass; however, to the researchers of aging, this extremely rare event is rather a reason for curiosity – and skepticism.

The Longevity Leaders Conference

February 4th, 2019 sees the launch of the Longevity Leaders Conference in St Paul’s, London, which promises to be an interesting event on the conference calendar.

The conference aims to cover both the science of aging research and the business side of the industry, in a similar manner to our own annual conference, Ending Age-Related Diseases, which we host in New York. Mixing the worlds of science and business is a good idea as we move ever closer to the first true rejuvenation technologies arriving.

It is essential to begin forging bonds between the researchers who are making the science a reality and the investors and angels who have the knowledge and expertise to take the science to market.

Happy to announce Dr. Graham Pawelec, Professor of Experimental Immunology at the Center for Medical Research, Tübingen as a speaker for the 2019 Undoing Aging Conference

“Graham is another speaker who has been a key member of the “SENS family” since its earliest days. He is one of the few eminent biogerontologists who can proudly claim to have spoken out regularly in favour of intervention in aging during the dark days when such talk was widely viewed by colleagues as misguided or even irresponsible. He continues to be a world leader in the study of immunosenescence, elucidating key aspects of why older people are so bad at fighting off infections, and I’m really looking forward to hearing his latest findings.” says Aubrey de Grey.

https://www.undoing-aging.org/news/dr-graham-pawelec-to-spea…aging-2019

#undoingaging #sens #foreverhealthy

Antibiotics eliminate senescent cells associated with ageing

Antibiotics have emerged as potentially lifespan-enhancing drugs, according to the results of new research carried out in the UK.

Genetic experiments that eliminate “senescent” cells – older cells, which lose the ability to divide – have already been proven to alleviate age-related dysfunction in model organisms.

Now, scientists have shown for the first time that an FDA-approved antibiotic – Azithromycin – can effectively target and eliminate senescent cells in culture.

Journal Club November 2018 — Senescent cells and Alzheimer’s

Tau protein aggregation is associated with cellular senescence in the brain is the topic for the November Journal Club. This is an important paper as it shows how senescent cells contribute to Alzheimer’s disease and how removing them appears to improve the condition. We will see you live on our Facebook page at 13:00 EST for the Journal Club show with Dr. Oliver Medvedik.

Abstract

Tau protein accumulation is the most common pathology among degenerative brain diseases, including Alzheimer’s disease (AD), progressive supranuclear palsy (PSP), traumatic brain injury (TBI), and over twenty others.