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Archive for the ‘life extension’ category: Page 5

May 17, 2022

Scientists Reverse Aging in Skin up to 40 Years! (May 2022 Science Update)

Posted by in categories: life extension, science

Hey it’s Han from WrySci-HX going over the breakthroughs of scientists rejuvenating skin cells of middle aged donors by several decades, overcoming complete paralysis in just one day, and more! See below ↓↓↓

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May 15, 2022

Eating Sea Squirts May Reverse the Signs of Aging

Posted by in categories: biotech/medical, life extension

Summary: Supplementing a diet with Ascidiacea, or sea squirts, reversed some of the main signs of aging in mouse models.

Source: Xi’an jiaotong-Liverpool University.

If you have ever looked in the mirror and seen graying hair and wrinkles or forgotten the name of a close friend, you’d be forgiven for wishing for a pill that could slow or even reverse the effects of aging.

May 15, 2022

A Physiology Clock for Human Aging: BP and FEV1 As Top Predictors

Posted by in categories: biotech/medical, information science, life extension, robotics/AI

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Papers referenced in the video:
A Physiology Clock for Human Aging (preprint)
https://www.biorxiv.org/content/10.1101/2022.04.14.488358v1

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May 14, 2022

Scientists Have Revived a Glimmer of Activity in Human Eyes After Death

Posted by in category: life extension

Scientists have momentarily restored a faint twinkle of life to dying cells in the human eye.

In order to better understand the way nerve cells succumb to a lack of oxygen, a team of US researchers measured activity in mouse and human retinal cells soon after their death.

Amazingly, with a few tweaks to the tissue’s environment, they were able to revive the cells’ ability to communicate hours later.

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May 14, 2022

Experimental Gene Therapy Increases Lifespan Of Mice By 41 Percent In Telomere Lengthening Study

Posted by in categories: biotech/medical, life extension

Telomeres are “caps” of non-coding DNA sequences present at both tips of our chromosomes, which are extremely important in the aging process. These caps protect our DNA as cells go through various life cycles of replication, however, each time a cell divides these telomeres are shortened and eventually contribute to disease and cellular aging.

Now, exciting new research published in the Journal PNAS has shown that an experimental gene therapy could be used to halt the shortening of these telomere caps in mice and by doing so increase the life span of these animals by up to 41 percent compared to controls.

Telomere length can be considered a marker of biological age and its shortening is a hallmark of a process called cellular senescence, which limits the replication of DNA in old damaged cells. As we age, telomere caps become shorter and shorter until the cell’s DNA becomes vulnerable to damage by cellular stresses that could lead to diseases such as cancer. Or the cell could ultimately reach senescence where it will no longer be able to replicate and so contribute to the aging process. For scientists looking at how to slow or even reverse aging, telomeres are of great interest.

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May 13, 2022

Learn about the Science that could one day overcome age related diseases

Posted by in categories: biotech/medical, life extension, science

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Here at Lifespan.io, we publish fact-checked news and deep interviews with aging researchers to help people track the development of treatments targeting aging. These treatments aim at preventing and curing age-related diseases and may improve lives of thousands of people around the globe!

Everyone deserves to know about the emerging opportunities in the field of healthy life extension research. Knowledge is empowering. In our articles and popular science videos, we discuss the progress, pros, cons, and social implications of innovative medicine for controlling aging, and the steps that are needed to accelerate its clinical implementation.

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May 13, 2022

Using an Endemic Virus as a Gene Therapy for Life Extension

Posted by in categories: biotech/medical, genetics, life extension

In a study printed in PNAS, researchers have shown that telomerase reverse transcriptase (TERT) can be given to cells in living mice through a viral vector, taking the idea of life-extending gene therapies from science fiction to reality.

Why a cytomegalovirus?

The human cytomegalovirus (CMV) is widely known as an endemic virus that, while usually asymptomatic, is known to cause with harmful effects in babies and older adults. However, some of its properties make this virus suitable for delivering gene therapies. As cytomegaloviruses can carry large genetic payloads and don’t overwrite the DNA of their host cells [1], replacing the genes of these viruses with beneficial DNA may be safer than approaches with more potential off-target effects; development in this area is ongoing, and a phase 1 human clinical trial has already been conducted [2].

May 12, 2022

Key Protein Identified for Brain Stem Cell Longevity

Posted by in categories: biotech/medical, life extension, neuroscience

A receptor that was first identified as necessary for insulin action, that also is located on the neural stem cells found deep in the brains of mice, is pivotal for brain stem cell longevity, according to a Rutgers study, a finding that has important implications for brain health and future therapies for brain disorders.

The study 0, appearing in the journal Stem Cell Reports, pinpoints a specific protein known as the insulin receptor (INSR), which is abundant on the neural stem cells that reside in the brain’s subventricular zone. During development, neural stem cells give rise to the entire nervous system, and they persist into adulthood. Over the lifespan these neural stem cells produce new neurons and non-neuronal cells that maintain the infrastructure and functioning of the brain.

Separately, the scientists made another finding when examining brain tumors: INSR plays a crucial role in sustaining and maintaining a population of specialized brain cancer cells known as glioblastoma (GBM) stem cells. When they inactivated the INSR in the GBM stem cells they inhibited the growth of those primitive tumor forming cells.

May 11, 2022

35 Years Biological Age Reversal: A Case Study | Review

Posted by in categories: biotech/medical, life extension

In this video we have a look at a case study of one person who has undergone hTERT gene therapy. The paper does not identify the subject I would guess it is Liz Parrish. The gene therapy was administered two times over a period of five years.

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Papers mentioned in the video:
Systemic Human Htert Aav Gene Transfer Therapy And The Effect On Telomere Length And Biological Age, A Case Report.
https://maplespub.com/article/systemic-human-htert-aav-gene-…ase-report.

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May 11, 2022

Scientists Discover Master Gene In Mice That Could Restore Hearing Lost In Aging

Posted by in categories: life extension, neuroscience

Hearing loss is normally permanent as sensory cells responsible for transmitting frequency information from the world around us to the brain get damaged from excessive noise and lifestyle factors as we age. Up until now, it’s been challenging to selectively regrow these sensory cells that play an important part in transmitting sound through the outer and inner ear to the brain, but that might be about to change.

In a study involving mice, scientists from Northwestern University have identified a single master gene that can program ear hair cells (known as cochlear hair cells) into becoming either outer or inner ear hair cells required for hearing. The breakthrough is reported in the journal Nature.

“Our finding gives us the first clear cell switch to make one type versus the other,” said lead study author Jaime García-Añoveros, PhD, in a statement. “It will provide a previously unavailable tool to make an inner or outer hair cell. We have overcome a major hurdle.”

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