face_with_colon_three Year 2017 nad plus is essentially immortality of the colon which can reduce colon aging.

Boosting the level of a coenzyme regulating metabolism could help treat constipation and other aging-related intestinal problems. Researchers in Hangzhou, China, led by Qinsong Sheng from the First Affiliated Hospital of Zhejiang University and Zhenyu Ju from Hangzhou Normal University studied differences in colon function between young and old mice. They showed that older animals had more difficulty in defecation through the gastrointestinal tract and that this was associated with a lower level of the coenzyme nicotinamide adenine dinucleotide (NAD). Treatment with an NAD precursor improved defecation ability, whereas administering a drug that blocks NAD synthesis led to worsened colon function in mice. These findings point to NAD as a key regulator of colon motility and suggest a therapeutic strategy for older individuals with bowel-movement problems.

face_with_colon_three year 2024.

Genes from regenerative organisms rejuvenate intestinal stem cells in fruit flies.

In a groundbreaking experiment, Japanese researchers transferred regenerative genes to fruit flies, leading to improved intestinal health and enhanced stem cell activity. This discovery opens new possibilities for anti-aging strategies in higher organisms, including humans, through targeted gene therapy.

Researchers including those from the University of Tokyo’s Graduate School of Pharmaceutical Sciences transferred genes from simple organisms capable of regenerating their bodies into common fruit flies, more complex animals that cannot. They found the transferred gene suppressed an age-related intestinal issue in the flies. Their results suggest studying genes specific to animals with high regenerative capability may uncover new mechanisms for rejuvenating stem cell function and extending the healthy lifespan of unrelated organisms.