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Category: life extension – Page 504

Partial Cellular Reprogramming to Reverse Cellular Aging

We have talked about the potential of partial cellular reprogramming in previous articles, and today, we want to draw attention to a new paper that promises to further refine reversal of epigenetic aging in cells.

As we age, our cells experience alterations to their epigenetic markers, and this changes gene expression, which is proposed to be a primary reason we age. Recently, there has been considerable interest in resetting these epigenetic markers to reverse cellular aging, and this paper builds on that.

Three of the study’s authors, Prof. Vittorio Sebastiano, Jay Sarkar, and Marco Quarta, have founded Turn.bio, a biotech company that is working to bring partial cellular reprogramming to humans. The company is also currently enjoying the leadership of Gary Hudson from Oisin Biotechnologies, who is standing in as CEO to help the company get off the ground and funded.

Novel research links an aging gut microbiome with heart disease

An intriguing new study, led by scientists from the University of Colorado Boulder, suggests an aging gut microbiome may be somewhat responsible for the degradation in cardiovascular heath that tends to appear as we grow older. The study is yet another addition to the growing body of evidence affirming the role gut bacteria plays in age-related disease.

We are happy to announce Dr. Mike West, founder, and CEO of AgeX, as a speaker for the 2019 Undoing Aging Conference

“We’ve left Mike to the last of these announcements, but he’s a prime example of “last but not least” — indeed, he is the only speaker we’ve invited who was also an invited speaker last year. That’s no accident: this exploding and immensely diverse field boasts a huge number of stellar researchers, such that I could happily fill the program without repetition even if the meeting lasted a week. But Mike is the ultimate pioneer in our field: he was the first rejuvenation researcher, by well over a decade, to make a success of taking early-stage work into the private sector. He’s still at the absolute forefront of this crusade, and I’m eager to learn what he has to say this year”, says Aubrey de Grey.

https://www.undoing-aging.org/news/dr-mike-west-to-speak-at-undoing-aging-2019

#undoingaging #sens #foreverhealthy

Fountain of youth for heart health may lie in the gut

“We have long known that oxidative stress and inflammation are involved in making arteries unhealthy over time, but we didn’t know why arteries begin to get inflamed and stressed. Something is triggering this,” Seals said. “We now suspect that, with age, the gut microbiota begins producing toxic molecules, including TMAO, which get into the blood stream, cause inflammation and oxidative stress and damage tissue.”

As our collection of resident gut bacteria changes with age, it increasingly produces harmful metabolites that damage veins and blood vessels, driving disease, a new study suggests.

ResTORbio Announces Phase 3 Human Trials

Last year, resTORbio announced the positive results of its phase 2b human trial, which targeted the aging immune system with an immune system-boosting drug. Now, the company has announced the news that its therapy is moving to a phase 3 study later this year after successful negotiation with the FDA.

Targeting the mTOR pathway of aging

ResTORbio is a biopharmaceutical company that is developing therapies that directly target the aging processes in order to prevent or cure age-related diseases. Its primary candidate drug is RTB101, which targets part of the mTOR pathway, one of the pathways involved in aging.

A Restorative Skin Cream May Reduce Inflammaging

The skin is our first line of defense against invading pathogens, and scientists at UC San Francisco and the San Francisco Veterans Administration (VA) Health Care System believe that it may be a cause of inflammaging, the age-related chronic inflammation that encourages a number of age-related diseases to develop.

As we age, we generally experience a rise in this low-grade chronic inflammation, thus increasing our risk for developing a variety of age-related diseases. There are a number of proposed sources of inflammaging, including senescent cell accumulation, cell debris, immunosenescence, and increasing bacterial burden.

In a previous article, we talked about the potential role of bacterial burden in relation to the microbiota of the gut and the age-related failure of the gut membrane, which allows bacterial contamination to invade the body and increase bacterial burden and inflammation. The gut microbiota has been proposed to be an origin point of inflammaging, and researchers suggest that the skin could be another.

Cryopreservation of Valia Zeldin

Text by Anton Zeldin, source: https://varlamov.ru/3352253.htmlTranslated by Alexey Turchin with the help of Google translate.

I started to date Valya in 2011 after the championship in “crocodile” — a game in which you need to portray words with the help of pantomime and guess them. For several years we communicated in very different ways, either parting or renewing relations, and only in 2016 we finally engaged. I realized that everything that I like to do in life, with this person I like even more. On both sides there was a confidence that no matter how we quarrel, nothing will change. We felt that a large concrete slab was laid at the base of our relationship.

In May 2017, we got married and started thinking about moving to Moscow. We worked together a lot — we made a discussion club and a telegram training game. It seemed to us that for the development of the latter it was important to be in the capital. We moved in mid-October, and lived in Moscow for almost a year. September 2, 2018 Valya shot down.

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