Archive for the ‘life extension’ category: Page 512

Dec 13, 2016

The first-in-man clinical trial targeting Alzheimer’s Tau protein

Posted by in categories: biotech/medical, life extension, neuroscience

Progress with Alzheimers and this time approaching it from the direction of Tau as a target rather than Beta Amyloid. This therapy has been tested in people and whilst it is only the first step hopefully this will lead to an effective treatment for this horrific diseases and and end to the suffering it brings.

Progress towards immunotherapies that can clear tau for Alzheimers here. Most therapies are focused on misfolded amyloid-β proteins but this particular approach targets Tau and the first in human test has proceeded!

“The authors of the study have developed a vaccine that stimulates the production of an antibody that specifically targets pathological tau, discovering its “Achilles’ heel”. It is able to do this because healthy tau undergoes a series of changes to its structure forming a new region that the antibody attacks. This new region (the “Achilles’ heel”), while not present in healthy tau, is present in diseased tau early on. Therefore, the antibody tackles all the different varieties of pathological tau. In addition to this important specificity, the antibody is coupled to a carrier molecule that generates a considerable immune response with the added benefit that it is not present in humans, thus avoiding the development of an immune reaction towards the body itself.”

#aging #crowdfundthecure

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Dec 13, 2016

Proposing Cross-Linking in the Extracellular Matrix to Contribute to Immunosenescence

Posted by in categories: biotech/medical, health, life extension

Removing Glucosepane crosslinks from tissue is one of the most important things groups like SENS Research Foundation are doing and their progress relies on our support.

In this interesting open access paper, the authors propose that too little attention has been given to immune cell behavior in tissues rather than in blood, and that means that researchers have overlooked the possibility that age-related changes in the extracellular matrix structures that support tissues might be a significant cause of the growing immune dysfunction that takes place in later life. One of the more important of these changes in the extracellular matrix is the growing presence of cross-links, persistent sugary compounds produced as a byproduct of normal metabolic operations that chain together the large molecules of the extracellular matrix. In doing so these cross-links change the chemical and structural properties of the matrix and the tissue as a whole, producing results such as loss of elasticity in skin and blood vessels, which in turn contribute to a variety of age-related diseases. If cross-linking does indeed contribute to immunosenescence, the decline of the immune system with age, then that only increases the importance of ongoing research funded by the SENS Research Foundation aimed at safely breaking down this unwanted form of metabolic waste. In humans near all persistent cross-links appear to involve a single class of compound, glucosepane. So in theory there is only a single target here, needing just one drug development program to make a large difference to long-term health and longevity.

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Dec 13, 2016

Is your brain aging faster than the rest of your body? An AI machine can now tell you

Posted by in categories: biotech/medical, business, life extension, robotics/AI

Determining brain age from an MRI scan has always been a time-consuming business. Now an AI machine gives the answer in seconds.

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Dec 12, 2016

A single heterochronic blood exchange reveals rapid inhibition of multiple tissues

Posted by in categories: biotech/medical, life extension

You have the power to change the future of medicine and how we treat age-related diseases. Here is an example of how grassroots fundraising is changing science.

Joining the circulatory system of an old with a young animal has been shown to rejuvenate old tissues. Here the authors describe a comparatively simple blood infusion system that allows for the controlled exchange of blood between two animals, and study the effects of a single exchange on various tissues.

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Dec 12, 2016

CellAge AMA: Targeting Senescent Cells with Synthetic Biology for Human Longevity : Futurology

Posted by in categories: bioengineering, biotech/medical, genetics, life extension

The CellAge AMA is open for questions, come along and ask about biotechnology, senolytics and so on.

Welcome to the CellAge AMA with Mantas Matjusaitis, PhD student in synthetic biology and founder of CellAge. I am here to talk about our work to improve the targeting of dysfunctional “senescent” cells in the body, and thereby aid in their eventual removal. This is important because removal of these cells has been shown to be a critical component in the effort to improve healthy human lifespan.

In short, CellAge is going to develop synthetic DNA promoters which are specific to senescent cells, as the promoters that are currently used for this purpose, such as the p16 gene promoter, suffer from various issues and limitations (not comprehensively targeting all senescent cells, collateral damage in targeting some cells that are not senescent, etc.). You can find more details in our technology video here, and on our Lifespan.io information page.

Continue reading “CellAge AMA: Targeting Senescent Cells with Synthetic Biology for Human Longevity : Futurology” »

Dec 11, 2016

CellAge: A New Startup Targeting Senescent Cells With Synthetic Biology — Longevity Reporter

Posted by in categories: bioengineering, biotech/medical, life extension

Check out the The Longevity Reporter interview with CellAge as they talk about rejuvenation biotechnology.

Innovative new startup Cell Age is using synthetic biology to develop new ways of targeting and removing senescent cells. We caught up with CEO Mantas Matjusaitis for an interview as their first fundraiser goes live on Lifespan.io (find it here)

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Dec 11, 2016

Exercise Improves Arterial Resilience to Age-Related Increases in Oxidative Stress

Posted by in categories: biotech/medical, health, life extension, nanotechnology

Excercise is the best low cost activity you can do as part of your personal longevity strategy. Here we see data showing it can improve resistance to oxidative stress.

Researchers digging deeper into the mechanisms by which exercise produces benefits have found that it improves the resistance of blood vessels to oxidative stress. With age the presence of oxidizing molecules and oxidative modification of proteins, preventing correct function, increases for reasons that include damage to mitochondria, the power plants of the cell. Oxidative damage to molecular machinery is somewhere in the middle of the chain of cause and effect that starts with fundamental forms of damage to cells and tissues and spirals down into age-related diseases. Near all of this oxidation is repaired very quickly, the damaged molecules dismantled and recycled, but in most contexts more of it over the long term is worse than less of it.


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Dec 10, 2016

Withholding amino acid depletes blood stem cells

Posted by in categories: biotech/medical, life extension

A new way to destroy and replace the immune system without harsh chemo or radiation could be the path to fixing immunosenescence.

Destroying and replacing the aging immune system could help with a host of age-related problems as well as autoimmune diseases. Radiation or Chemo were previously the only options which carries significant risks. With this new technique and a few others currently being developed we may soon have a way to replace aging dysfunctional immune systems and treating diseases like MS to boot.

#aging #crowdfundthecure

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Dec 10, 2016

An Interview with Mantas Matjusaitis of CellAge, Crowdfunding New Senescent Cell Markers and Removal Methodologies

Posted by in categories: bioengineering, biotech/medical, life extension

FightAging! interviews Mantas from CellAge about their campaign on Lifespan.io / Life Extension Advocacy Foundation and talks about senolytics and synthetic biology.

I mentioned CellAge some weeks ago; a new entry to the collection of companies and research groups interested in developing the means to safely identify and remove senescent cells from old tissues. A few days later one of those companies, UNITY Biotechnology, announced a sizable $116 million venture round, which certainly put the field on the map for anyone who wasn’t paying attention up until that point. In contrast, CellAge are determinedly taking the non-profit route, and intend to make the progress they create freely available to the field. Why are senescent cells important? Because they are a cause of aging, and removing them is a narrowly focused form of rejuvenation, shown to restore function and extend healthy life in animal studies. An increasing number of senescent cells linger in our bodies as we age, secreting signals that harm tissue structures, produce chronic inflammation, and alter the behavior of nearby cells for the worse. Senescent cells also participate more directly in some disease processes, such as the growth of fatty deposits, weakening and blocking blood vessels, that takes place in atherosclerosis. By the time that senescent cells come to make up 1% of the cell population in an organ, their presence causes noticeable dysfunction and contributes significantly to the progression of all of the common age-related diseases.

This coming Monday, the CellAge team will be hosting an /r/futurology AMA event — the post is up already if you want add your own questions for the scientists involved. Earlier this week, the CellAge principals launched a crowdfunding campaign with Lifespan.io: they are seeking $40,000 with stretch goals and rewards beyond that to get started on their vision for senescent cell therapies. If you’ve ever wanted the chance to have a DNA promoter sequence named after you … well, here it is. This has certainly been a busy year for community fundraising in rejuvenation research: I imagine that things will heat up even more in the years ahead. The CellAge view of the field of senescent cell clearance is that the markers currently used to identify senescent cells are too crude and lacking in specificity.

Continue reading “An Interview with Mantas Matjusaitis of CellAge, Crowdfunding New Senescent Cell Markers and Removal Methodologies” »

Dec 8, 2016

Age-Related Inflammation and its Effects on the Generation of Immune Cells

Posted by in categories: biotech/medical, life extension

The effects or Inflammation and the effect it has on the immune system are discussed in this article at FightAging!

With age, the immune system falls into a state of ever increasing chronic inflammation, a process known as inflammaging: the immune system is overactive, but nonetheless declines in effectiveness at the same time. Researchers here consider how inflammaging can damage the bone marrow stem cell populations responsible for generating immune cells, possibly the basis for a vicious cycle in which the failures of the immune system feed upon themselves to accelerate age-related damage and dysfunction.

Hematopoiesis is an active, continuous process involving the production and consumption of mature blood cells that constitute the hemato-lymphoid system. All blood cells arise from a small population of hematopoietic stem cells (HSCs) in the bone marrow (BM) that have two unique properties: self-renewing capacity, the ability to generate themselves, and multi-lineage differentiation capacity, the ability to produce all blood cell types. Since, in the steady state, most adult HSCs are in the G0 phase of the cell cycle, i.e., they are quiescent and are estimated to turnover slowly on a monthly time scale, daily hematopoietic production is mainly sustained by highly proliferative downstream hematopoietic progenitor cells (HPCs).

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