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Category: life extension – Page 514

Life Extension Beyond Borders… — Life Extension Beyond Borders Association

Here in beautiful Basel, Switzerland we open the section Aging and Drug Discovery, actually an intersection of AI, longevity and drug discovery in the Innovation Forums of Basel Life Conference 2018. Dr Alex Zhavoronkov (InSilico Medicine) and Dr Morten Scheibye-Knudsen (University Copenhagen) welcomed us. Dr Jay Olshansky (University of Illinois at Chicago) gave the first lecture. Some examples for age face recognition were shown, emphasising the importance of wrinkles from smoking or others and suggesting that looking younger means living longer! After the wonderful lecture I immediately went to correct my make-up!

Molecule Appears to Have Anti-Aging Effects on the Vascular System

Β-hydroxybutyrate seems to prevent senescence of vascular tissue.

According to a study by Georgia State University scientists, a molecule called β-hydroxybutyrate has anti-aging effects on the vascular system; more specifically, the molecule appears to prevent senescence of vascular cells by promoting cellular quiescence instead [1].

Study abstract

β-hydroxybutyrate (β-HB) elevation during fasting or caloric restriction is believed to induce anti-aging effects and alleviate aging-related neurodegeneration. However, whether β-HB alters the senescence pathway in vascular cells remains unknown. Here we report that β-HB promotes vascular cell quiescence, which significantly inhibits both stress-induced premature senescence and replicative senescence through p53-independent mechanisms. Further, we identify heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) as a direct binding target of β-HB binding to hnRNP A1 markedly enhances hnRNP A1 binding with Octamer-binding transcriptional factor Oct4 mRNA, which stabilizes Oct4 mRNA and Oct4 expression. Oct4 increases Lamin B1, a key factor against DNA damage-induced senescence. Finally, fasting and intraperitoneal injection of β-HB upregulate Oct4 and Lamin B1 in both vascular smooth muscle and endothelial cells in mice in vivo.

The Augmented Posthuman Body

https://paper.li/e-1437691924#/

Descartes once described the human body as a “fleshy machine” and today’s transhumanists would likely agree.

Philosopher Nick Bostrom writes that as we seek to peer farther into posthumanity our ability to concretely imagine what it might be like trails offend that the very essence of posthumanity is to be able to have thoughts and experiences that we cannot readily think or experience with our current capacities.

Today’s advances in science and technology will profoundly change what we understand as human. According to transhumanist philosophy humanity until this point has been a story of development for the survival and reproduction, but today thanks to advances in science we are entering a new phase where human beings are masters of their destiny. Therefore the Transhumanist movement envisions a future full of possibilities by broadening our potential as species by overcoming aging, cognitive shortcomings, involuntary suffering, and our confinement to planet Earth.

Researchers Identify Molecule With Anti-Aging Effects On Vascular System

ATLANTA—A molecule produced during fasting or calorie restriction has anti-aging effects on the vascular system, which could reduce the occurrence and severity of human diseases related to blood vessels, such as cardiovascular disease, according to a study led by Georgia State University.

“As people become older, they are more susceptible to disease, like cancer, cardiovascular disease and Alzheimer’s disease,” said Dr. Ming-Hui Zou, senior author of the study, director of the Center for Molecular and Translational Medicine at Georgia State and a Georgia Research Alliance Eminent Scholar in Molecular Medicine. “Age is the most important so-called risk factor for human disease. How to actually delay aging is a major pathway to reducing the incident and severity of human disease.

”The most important part of aging is vascular aging. When people become older, the vessels that supply different organs are the most sensitive and more subject to aging damage, so studying vascular aging is very important. This study is focused on vascular aging, and in old age, what kind of changes happen and how to prevent vascular aging.”

Prince Charles Says He “Utterly Objects” to The Idea of People Becoming Part Human, Part Machine

From the perspective of critics, there are many reasons to be concerned about the rise of artificial intelligence.

Billionaire inventor Elon Musk — perhaps the world’s most vocal AI antagonist — has warned that the technology could become “an immortal dictator from which we would never escape.”

Several years before his death, Stephen Hawking, the renowned theoretical physicist, said artificial intelligence could bypass biological evolution, leaving humans unable to compete.

NMN and the Cell Membrane

Today, we are going to take a look at the topic of NAD+, its precursor, nicotinamide mononucleotide, and the debate surrounding the ability of these molecules to pass through the cell membrane.

NAD+ is critical for cellular function

Nicotinamide adenine dinucleotide (NAD+) is a redox cofactor, but it is also a critical signaling molecule that regulates cell function and survival in response to environmental changes such as nutrient intake and cellular damage. Age-related changes to the level of NAD+ in the cell impacts mitochondrial function, nutrient sensing and metabolism, redox reactions, circadian rhythm, immune and inflammatory responses, DNA repair, cell division, protein-to-protein signaling, chromatin, and epigenetics.

Watch This 1999 Clip of Jack Ma Trying to Convince His Friends to Join Alibaba

I know 100 leaders in longevity area. All of them will be invited to the Longevity Impact Forum, to create sort of Alibaba of longevity. We can beat government agencies and big companies because of our spirit!

“Underdog” entrepreneur Jack Ma is now famous for his record setting IPO when he took his e-commerce company, Alibaba, public. But not many people know he started Alibaba in his one-room apartment with 17 friends. Watch where all the magic of Alibaba started and be sure to check out Jack Ma’s amazing life.

Methuselah Foundation Cofounder thinks Longevity Escape Velocity could be here by 2030

David Gobel was the first to put forward the concept of longevity escape velocity, or LEV. How far are we from LEV, assuming the current pace of research and no serious showstoppers?

Twelve years, or 2030, is David’s best guess based on what is known today.

David Gobel cofounded the Methuselah Foundation with Aubrey de Grey and continues to run the Methuselah Foundation today.

Methuselah Foundation has given millions of dollars to regenerative medicine research, backing ventures such as Organovo, Oisin Biotechnologies, and SENS Research Foundation.

Organovo invented and is now selling high-fidelity 3D human liver and kidney tissues to the research market, is providing contract services, and is on track to deliver a 3D liver patch to the clinic in two years.