Lifeboat Foundation

Scientists at Emory University School of Medicine have found that the dietary supplement alpha lipoic acid (ALA) can stimulate telomerase, the enzyme that lengthens telomeres, with positive effects in a mouse model of atherosclerosis.

In human cells, shortened telomeres, the protective caps at the ends of chromosomes, are a sign of aging and also contribute to aging.

Continue reading “Anti-aging effects (in mice) of a dietary supplement called alpha lipoic acid” »

https://www.youtube.com/watch?v=N6eDDIyS_EA

Longevity sticker shock is holding back progress in rejuvenation biotechnology.

Filmed at BIL 2016 in Los Angeles.

New feature story on transhumanism out on Digital Trends:

Zoltan Istvan is the Transhumanist party leader and independent candidate for the forthcoming U.S. elections. And he wants you to live forever.

I’m super excited to share my first fiction since writing “The Transhumanist Wager” four years ago. Vice Motherboard has published this short story of mine on the challenge of AI becoming religious—and what that might mean for humanity. It’s a short read and the story takes place just a few years into the future. And yes, the happenings in this story could occur.

For the second installment of our series exploring the future of human augmentation, we bring you a story by the Transhumanist Party’s presidential candidate (and occasional Motherboard columnist), Zoltan Istvan. Though he’s spent most of the last year traveling the nation in a coffin-shaped bus, spreading the gospel of immortality and H+, he’s no stranger to fiction. His novel, The Transhumanist Wager, is about the impact of evolving beyond this mortal coil. This story is even bolder. Enjoy the always provocative, always entertaining, Zoltan Istvan. –the editor.

Continue reading “​The Jesus Singularity” »

I’m guessing you’d be like: surprised .

So, here’s the deal. My biohacker friends led by Peter Fedichev and Sergey Filonov in collaboration with my old friend and the longevity record holder Robert Shmookler Reis published a very cool paper. They proposed a way to quantitatively describe the two types of aging – negligible senescence and normal aging. We all know that some animals just don’t care about time passing by. Their mortality doesn’t increase with age. Such negligibly senescent species include the notorious naked mole rat and a bunch of other critters like certain turtles and clams to name a few. So the paper explains what it is exactly that makes these animals age so slowly – it’s the stability of their gene networks.

What does network stability mean then? Well, it’s actually pretty straightforward – if the DNA repair mechanisms are very efficient and the connectivity of the network is low enough, then this network is stable. So, normally aging species, such as ourselves, have unstable networks. This is a major bummer by all means. But! There is a way to overcome this problem, according to the proposed math model.

Continue reading “What would you say if I told you that aging happens not because of accumulation of stresses, but rather because of the intrinsic properties of the gene network of the organism?” »

Will Ichor Therapeutics be the first to clinic with a SENS based approach?

As I mentioned last week, earlier this year Fight Aging! invested a modest amount in the Ichor Therapeutics initiative to develop a treatment for macular degeneration, joining a number of other amateur and professional investors in helping to get this venture started. The approach taken here is based on the results of research carried out at the Methuselah Foundation and SENS Research Foundation over much of the past decade, funded by philanthropists and the support of our community of longevity science enthusiasts. This is how we succeed in building the future: medical science in the laboratory leads to medical development in startup companies, each new stage bringing treatments capable of repairing specific forms of age-related molecular damage that much closer to the clinic.

Ichor Therapeutics is one of a growing number of success stories to emerge from the SENS rejuvenation research community. Young scientists, advocates, and donors involved in earlier projects — years ago now — have gone on to build their own ventures, while retaining an interest in stepping up to do something meaningful to help bring an end to aging. Back in 2010, Kelsey Moody worked on the LysoSENS project to find ways to break down damaging metabolic waste in old tissues; fast-forward six years, and he is the now the CEO of a successful small biotechnology company with a great team, taking that very same technology and putting it to good use. I recently had the chance to ask Kelsey a few questions about the future of SENS rejuvenation research, as well as how the Ichor scientists intend to construct a new class of therapy for macular degeneration, one based on removing one of the root causes of the condition.

Continue reading “An Interview with Kelsey Moody of Ichor Therapeutics, Bringing a SENS Therapy for Macular Degeneration to the Clinic” »

Leonard Guarente is certain he’s succeeded where doctors (and quacks) before him have failed. His pill will either extend lives or tarnish his career.

And, a few words from Ray.

According to Ray Kurzweil, we’re approaching a time when humans will begin to radically extend their lifespans. This sounds good on the surface, but will we have enough resources to support everyone? And won’t living indefinitely get boring eventually? Not so much, Kurzweil says.

Continue reading “Ray Kurzweil Explains Why Radical Life Extension Will Be Better Than You Think” »

More info. on some research that I came across a few weeks ago on a new bioimaging technique to help map and understand the nervous system which is one of the hardest areas of the brain to map and monitor — this is truly groundbreaking on so many fronts such as precision meds. research, computer mapping of the brain and neuro pathways, etc. If will be very impressive to see how much this accelerates the efforts in finding a cure for diseases such as Dystonia.

MUNICH, Germany, Aug. 22 (UPI) — Scientists at Ludwig Maximilian University have developed a technique for turning the body of a deceased rodent entirely transparent, revealing the central nervous system in unprecedented clarity.

Researchers are hopeful the new and improved view will help scientists understand how traumatic brain injuries, strokes and aging yield chronic disorders like dementia and epilepsy.

Continue reading “New bioimaging technique offers clear view of nervous system” »