Archive for the ‘life extension’ category: Page 6

Oct 24, 2022

A pro-oxidant combination of resveratrol and copper down-regulates multiple biological hallmarks of ageing and neurodegeneration in mice

Posted by in categories: biotech/medical, life extension

ROS are short lived molecular species containing an unpaired electron which makes them highly reactive as they search for another electron to pair with, and in the process can damage biomolecules such as DNA, proteins and lipids54. ROS induced oxidative stress is known to have multiple deleterious effects on host cells55. However, we have reported that, paradoxically, when ROS is artificially generated outside the cell in the extracellular spaces of the body, they can have wide ranging therapeutic effects18,19,20,26,27. Admixing R with Cu leads to generation of oxygen radicals by virtue of the ability of R to reduce Cu (II) to Cu (I)23,25. Oxygen radicals that are generated in the stomach upon oral administration of R–Cu are apparently absorbed to have systemic effects in the form of deactivation/eradication of extracellular cfChPs. We have shown that cfChPs have wide-ranging damaging effects on host cells. For example, cfChPs can readily enter into the healthy cells to damage their DNA, activate inflammatory cytokines and promote apoptosis via the mitochondrial pathway13,14. Given that 1 × 109–1 × 1012 cells die in the body every day56,57, we have hypothesised that repeated and lifelong assault on healthy cells by cfChPs derived from the dying cells may be the underlying cause of ageing15,16. In support of this hypothesis we show in this article that prolonged oral administration of R–Cu to ageing mice down-regulated multiple biological hallmarks of ageing and neurodegeneration by virtue of its ability to deactivate cfChPs. Our results suggest that R–Cu may qualify as an ideal anti-ageing agent since it has the potential to simultaneously retard or delay the many conditions that are associated with ageing2. To be globally applicable, an ideal anti-ageing agent should also be inexpensive and non-toxic—the two criteria that are also met by R–Cu. The latter can be easily administered orally, and both R and Cu are already approved for human use. An illustrated summary of the study design and the mechanisms by which R–Cu generated oxygen radicals eradicate cfChPs from brain micro-environment leading to down-regulation of ageing hallmarks is provided in Fig. 10.

The mechanism(s) by which R–Cu down-regulates the multiple biological hallmarks of ageing and neurodegeneration needs elaboration. Reversal of telomere shortening by R–Cu may suggest that telomere shortening could be a consequence of DNA damage inflicted by cfChPs which shear off telomere ends causing them to shorten. We observed differential effects between female and male mice with respect to telomere abnormalities. R–Cu effects in preventing telomere abnormalities in female mice were statistically significant for all parameters tested, while this was not the case in male mice. The biological explanation for this discrepant finding remains to be determined. Breakage of telomere ends may also help to explain our detection of persistent γ-H2AX signals in telomere regions of brain cells (DNA-SCARS)—an established signature of senescence43. The bare chromosomal ends can fuse with each other to lead to chromosomal instability and aneuploidy48, as was detected in our study.

Oct 23, 2022

That Our Body Has A MEMORY OF YOUTH Has Been Proved | Dr David Sinclair Interview Clips

Posted by in categories: biotech/medical, economics, genetics, life extension

Just a quick vid. He mentions the hope of replacing current gene therapy with a pill or three which I heard Cynthia Kenyon say many years ago.

Dr David Sinclair talks about longevity genes, genes therapies and his works on resetting the eyes in this short clip.

Continue reading “That Our Body Has A MEMORY OF YOUTH Has Been Proved | Dr David Sinclair Interview Clips” »

Oct 22, 2022

New Protein Identified That May Contribute to Alzheimer’s Disease

Posted by in categories: biotech/medical, life extension, neuroscience

Alzheimer’s disease (AD) is a debilitating progressive illness that begins with mild memory loss and slowly destroys cognitive function and memory. It currently has no cure and is predicted to affect over 100 million people worldwide by 2050. In the United States, AD is the leading cause of dementia in older adults and the 7th most common cause of death, according to the National Institute on Aging.

Ongoing Alzheimer’s research is focused on two key neurotoxic proteins: amyloid beta (Aβ) and tau. Although these proteins have been shown to be associated with AD, the levels of Aβ and tau do not consistently explain or correlate with the severity of cognitive decline for some people with the disease.

Investigators at Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, set out to identify other proteins that may be directly involved with fundamental aspects of AD, like synaptic loss and neurodegeneration. They exposed laboratory neurons to human brain extracts from about 40 people who either had AD, were protected from AD despite having high Aβ and tau levels, or were protected from AD with little or no Aβ and tau in their brains.

Oct 22, 2022

Extending Health Spans

Posted by in category: life extension

BioViva CEO Liz Parrish believes we can extend lifespans by extending telomeres.

Oct 21, 2022

Is Aging Inevitable?

Posted by in category: life extension

Some animals do not age at all and prove that aging is not inevitable. Scientists are working on ways to slow down and even reverse aging.

Oct 21, 2022

Benjamin Button For Real? Scientists Are Close To Cracking The Code To Reverse Aging

Posted by in categories: biotech/medical, life extension

The discovery that earned Japan’s Shinya Yamanaka the 2012 Nobel Prize in Medicine has paved the way for new research proving that aging is a reversible process. Currently just being tested on lab mice, will the cellular reprogramming soon offer eternal youth?

Oct 21, 2022

Exercise Counters the Age-Related Accumulation of Senescent Cells

Posted by in categories: biotech/medical, life extension

Preclinical and clinical evidence for exercise as a senescence-targeting therapy and areas needing further investigation are discussed.

Oct 20, 2022

Prof. Dr. Gordan Lauc, Ph.D. — Founder & CEO, Genos; CSO, GlycanAge; Advancing The Glycosciences

Posted by in categories: biotech/medical, chemistry, genetics, life extension

(http://www.pharma.unizg.hr/en/about-us/staff/gordan–lauc, 450.html) is Professor of Biochemistry and Molecular Biology at the University of Zagreb, Faculty of Pharmacy and Biochemistry, and Founder and CEO of Genos Ltd. (https://genos-glyco.com/), a research-intensive SME located in Zagreb, Croatia with core of expertise in molecular genetics and glycomics (The comprehensive study the entire complement of sugars, whether free or present in more complex molecules of an organism) and they perform contract research, contract analysis and service for numerous universities, hospitals and private individuals in Europe and overseas.

Prof. Dr. Lauc also is CSO of GlycanAge LTD (https://glycanage.com/), a company that has developed a ground-breaking test that analyses your personal glycobiome for insights in improving your health and monitoring your biological age, and Co-Director of the Human Glycome Project (https://human-glycome.org/).

Continue reading “Prof. Dr. Gordan Lauc, Ph.D. — Founder & CEO, Genos; CSO, GlycanAge; Advancing The Glycosciences” »

Oct 20, 2022

Reincarnation and Robots with Ben Goertzel

Posted by in categories: life extension, robotics/AI, singularity

Ben Goertzel, PhD, is author of many books on artificial intelligence including Ten Years to the Singularity if We Really Really Try; Engineering General Intelligence, Vols. 1 and 2; The Hidden Pattern: A Patternist Philosophy of Mind; and The Path to Posthumanity. He is also editor (with Damien Broderick) of an anthology about parapsychology titled, Evidence for Psi: Thirteen Empirical Research Reports. He is chief scientific officer for Hanson Robotics in Hong Kong.

Here he notes that, while the question of reincarnation in robots seems outlandish, most of our present technology would have seemed nonsensical and incomprehensible to earlier generations of humans. He quotes the 14th Dalai Lama who suggested (half-jokingly) that artificial intelligence programmers of the future might incarnate into robots. He cites Stephen Braude’s book, Immortal Remains, as demonstrating that we must consider some version of consciousness operating outside of the body. He outlines the sort of scientific and metaphysical models that might lead to such a development.

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Oct 20, 2022

Association between work characteristics and epigenetic age acceleration: cross-sectional results from UK — Understanding Society study

Posted by in categories: employment, genetics, life extension

Occupation-related stress and work characteristics are possible determinants of social inequalities in epigenetic aging but have been little investigated. Here, we investigate the association of several work characteristics with epigenetic age acceleration (AA) biomarkers.

The study population included employed and unemployed men and women (n = 631) from the UK Understanding Society study. We evaluated the association of employment and work characteristics related to job type, job stability; job schedule; autonomy and influence at work; occupational physical activity; and feelings regarding the job with four epigenetic age acceleration biomarkers (Hannum, Horvath, PhenoAge, GrimAge) and pace of aging (DunedinPoAm, DunedinPACE).

We fitted linear regression models, unadjusted and adjusted for established risk factors, and found the following associations for unemployment (years of acceleration): HorvathAA (1.51, 95% CI 0.08, 2.95), GrimAgeAA (1.53, 95% CI 0.16, 2.90) and 3.21 years for PhenoAA (95% CI 0.89, 5.33). Job insecurity increased PhenoAA (1.83, 95% CI 0.003, 3.67), while working at night was associated with an increase of 2.12 years in GrimAgeAA (95% CI 0.69, 3.55). We found effects of unemployment to be stronger in men and effects of night shift work to be stronger in women.

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