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Category: life extension – Page 630

Ampakines are known mental stimulants, but in rats they can also shelter the brain from age-related decline and even reverse deterioriation

A number of changes happen in the aging brain and one of these is a dendritic loss which onsets around middle age. In a new study, researchers have shown a particular drug belonging to the ampakine class of compounds, has significant neuroprotective properties.

Shielding the brain

Ampakines have already been shown to aid cognitive function in older rats, and they also appear to boost levels of BDNF, brain derived neurotrophic factor, which is associated with staving off neural decline. In the latest study using one such ampakine, older rat brains were compared to adolescent samples. While untreated rats had short dendrites and fewer dendritic branches, after 3 months of treatment older rat brains were identical to younger ones. If that wasn’t enough, they showed enhanced signalling and even had more dendritic spines than the adolescent rats did.

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Becoming immortal is one of mankind’s many quixotic notions that most people will relegate to the world of fantasy and science fiction. However, there is a subset of prominent scientists who believe that immortality is not only attainable, but it is something that will come to fruition in as little as 25 years. This idea is shared by men like Google’s Director of Engineering, Ray Kurzweil; Tesla Motors CEO, Elon Musk; and one of the most interesting presidential candidates outside of Donald Trump and Deez Nuts, Zoltan Istvan. All three men identify as trans-humanist, and for those who don’t know, trans-humanism is the idea that mankind will one day be able to transcend our biological limitations through the use of science and technology; not to mention, the movement has accumulated over 3 million supporters worldwide. So the question remains, with the multitude of prominent intellectuals who believe immortality is a tangible goal, just how will they go about achieving it? Well, the six answers below could possibly hold the key to everlasting life.

Number Six: Uploading Minds to Computers. Futurists believe that at some point in the near future we will be able to copy and scan all of the data that exists in our brains and upload the information into a computer. This will allow us to perpetually exist as incorporeal inhabitants of cyberspace. Of course, the idea of mind uploading is still purely science fiction, but if it ever becomes tangible, progeny could possibly live in a limitless world, that echoes notions expressed in the Matrix; minus the robot despots.

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Aging, inflammation, cancer, and cellular senescence are all intimately interconnected. Deciphering the nature of each thread is a tremendous task, but must be done if preventative and geriatric medicine ever hope to advance. A one dimensional analysis simply will not suffice. Without a strong understanding of the genetic, epigenetic, intercellular, and intracellular factors at work only an incomplete picture can be formed. However, even with an incomplete picture useful therapeutics can and are being developed. One face is cancer, a number of diseases characterized by uncontrolled cell division. The other is slue of degenerative disorders stemming from deterioration in regenerative capacity.

Geroprotectors are a diverse and growing family of compounds that assist in preventing and reversing the unwanted side-effects of aging. Senolytics, a subset of this broad group, accomplish this feat by encouraging the removal of decrepit cells. A few examples include dasatinib, quercetin, and ABT263. Although more research must be done, there are a precious handful of studies accessible to anyone with the inclination to scroll to the works cited section of this article. Those within the life extension community and a few enlightened souls outside of it already know this, but it bears repeating: in the developed world all major diseases are the direct result of the aging process. Accepting this rather simple premise, and you really ought to, should stoke your enthusiasm for the first generation of anti-aging elixirs. Before diving into the details of this promising new pharmaceuticals we must ask what is cellular senescence? What causes it? What purpose does it serve?

Depending on the context in which they are operating a single gene can have positive or negative effects on an organism’s phenotype. Often the gene is exerting both desirable and undesirable influences at the same time. This is called antagonistic pleiotropy. For example, high levels of testosterone can confer several reproductive advantages in youth, but in elderly men can increase their likelihood of developing prostate cancer. Cellular senescence is a protective measure; it is a response to damage that could potentially turn a healthy cell into a malignant one. Understandably, this becomes considerably more complex when one is examining multiple genes and multiple pathways. Identifying all of the players involved is difficult enough. Conboy’s famous parabiosis experiment shows that alterations in the microenviornment, in this case identified and unidentified factors in the blood of young mice, can have be very beneficial to their elders. Conversely, there is a solid body of evidence that shows senescent cells can have a bad influence their neighbors. How can something similar be achieved in humans without having to surgically attach a senior citizen to a college freshman?

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This is not good especially as we look at those aspirations for more nanobots to connect us to the cloud plus Mr. Kurzweil’s desire to live forever.

Medical device manufacturers are struggling to safeguard their newly connected designs from current and emerging security threats.

Natick, MA (PRWEB) January 29, 2016.

The medical device sector will be among the fastest growing markets for embedded security software through the next five years, according to a new report by VDC Research (click here to learn more). The market for medical devices spans a variety of hardware profiles including high-performance imaging systems, mobile diagnostic equipment and pumps, and wearable or implantable devices. Until recently, the majority of medical device manufacturers and others within the ecosystem treated security as an optional value-add under the misconception that their devices/products did not produce valuable data or would be a target for a hacker. The Internet of Things has enlarged the crosshairs on medical devices as such systems become more accessible and integrated with enterprise hospital platforms.

Continue reading “Connected Medical Devices Are Sick with Vulnerabilities, According to New Research” | >

The legal death of Marvin Minsky was publicly reported on Monday, January 25, 2016. There has been speculation on the part of numerous individuals and publications that he may have been cryopreserved by Alcor. This notice is Alcor’s formal response to inquiries on this issue.

In a public ceremony at the Extro-3 conference in 1997, nanotechnology pioneer Eric Drexler presented Prof. Minsky with a bracelet given to all new Alcor members. This bracelet provides emergency contact information and basic instructions. Minsky has spoken publicy many times about his advocacy of overcoming aging and the inevitability of death and about cryonics (human cryopreservation) as a last resort. He was also among the 67 signatories of the Scientists Open Letter on Cryonics and a member of Alcor’s Scientific Advisory Board. This much is public knowledge. None of this necessarily means that Prof. Minsky had cryopreservation arrangements at the time of legal death. Alcor neither confirms nor denies whether Prof. Minsky had such arrangements.

Alcor’s official response may puzzle some readers, so we would like to point out the privacy options that have been and currently are available to our members. When a member signs up for cryopreservation by Alcor, they have four options:

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Researchers at the University of Colorado have created a unique, light-activated nanotherapy to destroy antibiotic resistant bacteria

The pursuit of longevity requires continued, effective antibiotics. Otherwise, you could be as fit as a fiddle at 100 and still be downed by a nasty, resistant strain.

While bacterial strains resistant to current drugs are rapidly rising across the globe, infecting 2 million people last year, researchers are turning to increasingly innovative ways to destroy these populations. Nanotechnology is one such, increasingly promising technology.

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Further progress with telomeres by Maria Blasco which clearly demonstrates the link between telomeres and aging and why they are a primary “clock”.

“These findings suggest that it is the ability of different species to maintain telomeres rather than average telomere length per se that may be determinant of species longevity”

So if we maintain telomeres (either directly or by repairing the cause of that damage) as many biologically immortal creatures do could we expect to see life extension? So far in animals tested that answer is yes! Its not the only thing that needs to be addressed to combat aging but it looks like an important one.

Read the latest article version by Christian Bär, Maria A. Blasco, at F1000Research.

Continue reading “F1000Research Article: Telomeres and telomerase as therapeutic targets to prevent and treat age-related diseases” | >

It’s in German, but easy to translate via the internet. Lots of pictures:

Von Veit Medick

Wahlkampf in den USA: Kennen Sie Zoltan Istvan? Er reist in einem großen Sarg durch die USA. Und er will ins Weiße Haus. Unterwegs mit dem ungewöhnlichsten Präsidentschaftskandidaten der Vereinigten Staaten.

Video abspielen…Video

Continue reading “Here’s the online version of the feature on the Immortality Bus and transhumanism in Der Spiegel, one of Europe’s larger publications” | >