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Category: life extension – Page 633

Infertility breakthrough as cancer drug sparks growth of new eggs in ‘astonishing’ discovery

Infertile women have been offered new hope after scientists found that a common cancer drug triggers the development of new eggs, an outcome which was previously thought to be impossible.

In a discovery hailed as “astonishing”, researchers at the University of Edinburgh proved it is possible to reverse the clock and coax the ovaries back into a pre-pubescent state where they begin to produce new eggs.

Women are born with all their eggs, which is why conceiving becomes harder with age, because the eggs grow old, become damaged and eventually run out entirely.

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Fight Aging predicts the sequence of arrival for meaningful antiaging therapies

The full antiaging rejuvenation toolkit of the next few decades will consist of a range of different treatments, each targeting a different type of molecular damage in cells and tissues. Fightaging predicts the likely order of arrival of some of these therapies, based on what is presently going on in research, funding, and for-profit development.

1) Clearance of Senescent Cells

Everon Biosciences, Oisin Biotechnologies, SIWA Therapeutics, and UNITY Biotechnology are all forging ahead with various different approaches to the selective destruction of senescent cells. No doubt many groups within established Big Pharma entities are also taking a stab at this, more quietly, and with less press attention. UNITY Biotechnology has raised more than $100 million to date, demonstrating that there is broad enthusiasm for this approach to the treatment of aging and age-related disease.

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You shop. Amazon gives

Please support SENS Research on Amazon Smile this Christmas smile

Dont forget you can help SENS Research Foundation even during your Christmas shopping this year! Using Amazon Smile you can buy your gifts in the normal way but Amazon will donate 0.5% of the price of your eligible AmazonSmile purchases to us whenever you shop on AmazonSmile. bigsmile

#aging #sens

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How to end aging: Aubrey de Grey at TEDxOxbridge

The weekend is here so let’s kick it off with a great talk by Dr. Aubrey de Grey at TED in 2014.

Biotechnologist Aubrey de Grey talks about aging as a disease — and how it can be cured.

In the spirit of ideas worth spreading, TEDx is a program of local, self-organized events that bring people together to share a TED-like experience. At a TEDx event, TEDTalks video and live speakers combine to spark deep discussion and connection in a small group. These local, self-organized events are branded TEDx, where x = independently organized TED event. The TED Conference provides general guidance for the TEDx program, but individual TEDx events are self-organized.* (*Subject to certain rules and regulations)

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Drugs to Extend Life — Nathaniel David, CEO of Unity Biotechnology

Nathaniel David from Unity Biotech giving a talk about the potential of Senolytics and how science can break the natural limit to lifespan. David is the CEO of Unity Biotechnology a company taking SENS based Senolytic drugs into human clinical trials in the next year or so. Very exciting as this is the first true rejuvenation biotechnology therapy to be deployed in humans.

Unity is leading the way for the first rejuvenation technologies in the #sens model. Here we have Nathaniel David from Unity talking about the potential of Senolytics and increased lifespans.

Unity Biotechnology is one of a number of companies developing Senolytic therapies to clear senescent cells from the body and they will no doubt be joined by them in the future a sure sign of the rising interestin the field.

There is however no doubt at this moment in time that Unity is leading the charge and with recent investment from Amazon’s Bezos and their movement into human clinicial trials within a year or so they are certainly the pioneers of this exciting new therapy.

#aging #crowdfundthecure

Continue reading “Drugs to Extend Life — Nathaniel David, CEO of Unity Biotechnology” | >

Mitochondrial Repair Project

A look back at one of the milestones for SRF and the first successful fundraiser on Lifespan.io for MitoSENS.

We need your support at this critical juncture of the MitoSENS project. The MitoSENS team has already demonstrated the rescue of cells containing mitochondrial mutations, and has recently generated highly promising preliminary data showing the rescue of the complete loss of a mitochondrial gene. Our next steps will focus on improving the effectiveness of the targeting system, so that we can repeat our success with one mitochondrial gene to all thirteen. We will then transition this work into animal models of mitochondrial dysfunction. This would be a crucial step in what may be the development of an eventual cure for aging and aging related diseases.

We have a talented team of highly trained mitochondrial biologists working on MitoSENS. Right now the rate-limiting factor is the cost of the expensive reagents that we use for these experiments. Increasing our funding with this campaign will allow us to double the pace of our research and bring results to the public that much faster. We have made preliminary progress on rescuing function with a second gene, ATP6, and your support will help us perfect our targeting of both ATP8 and ATP6. This requires more cells, more viruses, and many new synthetic gene sequences. Specifically, we will spend your generous donations on cell culture reagents, oxygen consumption measurements, virus production, quantitative reverse transcription PCR, DNA synthesis services, and publication of our results in a peer-reviewed journal.

Your support will help take us there.

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Fitness trackers might help us live longer

Wearable fitness devices could help you with your personal longevity strategy.

NEW YORK — Activity monitors could improve our health and extend our lives — if only we could be motivated to use them. Those are the conclusions of two new studies about the promise and perils of relying on fitness trackers to measure and guide how we move.

The monitors, which are expected to be a popular holiday gift again this year, can generally track our steps, speed, stance (sitting or not), distance, energy expenditure and heart rate. The absolute accuracy of these numbers, however, is somewhat suspect, with past studies finding errors in many of the monitors’ measurements. But the inaccuracies are usually consistent, the studies show, so the trackers can reliably indicate how our movements change from day to day.

The broader problem with activity monitors has been that we have not known whether the information they generate actually relates directly to our health. We have not had proof that what most trackers tell us is healthy actually is.

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Linking Excess Fat Tissue, Immune Dysfunction, and Cellular Senescence in Aging

Fat tissue, immune dysfunction and cellular senescence are closely related. Here we have some commentary from Reason at Fightaging! once of our new Patron sponsors about some recent research liking these factors together.

“Cellular senescence is one of the root causes of aging, and there are at present serious, well-funded efforts underway to produce rejuvenation therapies based on the selective destruction of senescent cells in old tissues. This progress is welcome, but it could have started a long time ago. It has taken many years of advocacy and the shoestring production of technology demonstrations to finally convince the broader community of scientists and funding institutions that the evidence has long merited serious investment in treatments to clear senescent cells”.

#sens #aging

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