Lifeboat Foundation: Safeguarding Humanity
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Category: life extension – Page 644

Aubrey de Grey wants to save lives. He wants to save as many as he possibly can, as soon as he can, and to do it he is going to fix ageing.

The prominent scientist and futurologist is on a crusade to beat ageing and when he does it will mean that we stay healthy and live longer – possibly for up to hundreds of years.

But, as de Grey emphasises, his primary goal is not just making people live longer; he wants us to live healthily, he wants to restore us to a state of health that is “fully functional in every way”. The ability to live for hundreds of years is just a side effect.

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We’re born, we grow, we age, and then we die. Well, maybe not all of us, according to a new study on the animals amongst us who, while they continue to grow older, don’t deteriorate with age.

A new study out of Nature takes a comparative look at the life cycles of 46 different species (us included) and finds that not all species live by this pattern of decline that we do. In fact some, the hermit crab, for instance, seem to have turned the whole process upside down. Virginia Hughes at National Geographic explains:

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Not everyone wants to sleep in. A growing transhumanism community wants to sleep less, and better, and they’re going to great lengths to make it happen.

For those unaware, transhumanism is an intellectual and cultural movement that aims to improve the human condition, to push beyond our biological limitations, largely through technological advancements. They’re particularly focused on extreme longevity. But with treatments for an extended healthy life still works in progress (and playing out on a very long timeline), some transhumanists have turned their attention to sleep.

The average well-rested person sleeps eight hours a day. The average American lives 79 years. That’s a little more than just 50 years being awake. Life is much shorter than you realized — at least if you agree with your typical sleep-hacker that sleeping is wasted downtime.

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Another excellent blog by Dr Michael fossel PhD, md. Alzheimer’s, Parkinson’s and other related diseases could be treated potentially using telomerase.

Alzheimer’s: One Disease?

Date posted: 25.08.2015.

Most of us have wondered about what causes Alzheimer’s. As commonly happens, we stumble badly when we make assumptions, even in asking questions, let alone in trying to answer those questions. The question “what causes Alzheimer’s?” presupposes that there is a single such disease (Alzheimer’s) and that we can define it well enough to ask about “its” cause. Neither of these is probably an accurate assumption. The reality is that there is considerable difficulty in agreeing on the “hallmarks” (the pathognomonic characteristics that define AD) and the “boundaries” between AD and other somewhat similar diseases on the differential diagnosis. Comparing Alzheimer’s to many other age-related neurological diseases can be humbling – and it should be. Small wonder we have so much trouble understanding the cause, let alone finding a cure when we don’t really know what we’re looking at.

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If you want to increase your risk of multiple diseases, then smoking is one of surest ways to do it; it can even accelerate aging. So how do some long-term smokers beat the odds?

Long-lived smokers are fascinating. Not only do they live a long time, but they also appear unaffected by their habit. For most of us, smoking has been confirmed to be ‘toxic’, but these outliers somehow overcome this. So how can these people reach old age despite having smoked most of their life? Scientists predicted they must have some unusual genes, and they were right.

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Stem cells coming along nicely, Stanford demonstrate how creating artificial stem cell niches improve grafting and regeneration of bone and it should have a broad application for other tissues. Properly developed we could regenerate organs and tissues by injecting enough stem cells in these manufactured protective niches.

One could potentially take it a stage further and modify the stem cells with genes of interest to make them more robust. Ex-vivo cell manipulation is also considerably cheaper than in-vivo therapy.

New porous hydrogel could boost success of some stem cell-based tissue regeneration, researchers say.

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Our gut and the microbiome play a crucial role in our health, but could better understanding of that role help us avoid disease and live longer?

The microbiome weighs 2–3 pounds and contains 10 times more cells than our own, but we’ve neglected our microbial tenants for a long time. These little denizens help us break down food, provide key nutrients and even play a role in inflammation and the integrity of our intestinal tract. It’s no surprise then that fermented foods and probiotics are gaining popularity as we become more aware of how important our gut is. Recent evidence even links poor digestive health to chronic inflammation and Parkinson’s disease.

New research suggests that both gut integrity, and the amount and type of bacteria that reside within it, can actually predict an individual’s health. They may even quicken or slow the pace of aging.

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Dr Michael Fossel is a PhD and MD heading up telomerase research and therapy and has kindly written a blog article for Bioviva detailing the work both they and his company Telocyte are doing to fight back against Alzheimer’s.

How Alzheimer’s Can Be Prevented and Cured…

Michael Fossel, MD, PhD

As I said in my medical textbook on aging, “If age is a thief, then the greatest treasure we lose is ourselves.” We fear Alzheimer’s not simply because it takes away our health, but because it steals our souls.

Once, we thought it was simply “old age” that gradually killed the cells that carry information and memory. These are brain cells that make us who we are and define our consciousness.

Only in the past two decades, have we gradually come to realize that it’s not the neurons, which are merely the innocent bystanders in the tragedy,

but the microglial cells that cause the disease. It’s our microglia, not our neurons that steal our very souls.

Continue reading “Curing Alzheimer’s” | >

Kim Suozzi died at age 23 from glioblastoma — a deadly brain tumour.

When she died in 2013, she made sure her fight for survival, albeit an unusual one, would not be forgotten.

She wanted to live forever through a computer and chose to have her brain frozen in the hopes that it may one day be resurrected and transformed into digital code.

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