Lifeboat Foundation

Aging is a major risk factor for most chronic conditions, evidence shows, yet much of current research focuses on addressing specific diseases. The new translational geroscience initiative at Yale School of Medicine (YSM) seeks to change that approach by studying the effects of aging on various ailments.

“Yale School of Medicine has a long legacy in studying aging, but with this new initiative we are bolstering our ability to delineate basic mechanisms of healthy and accelerated aging,” said Nancy J. Brown, MD, Jean and David W. Wallace Dean of the Yale School of Medicine and C.N.H. Long Professor of Internal Medicine.

The mechanisms underlying the aging process are often also driving the development and progression of chronic conditions, explains Thomas Gill, MD, Humana Foundation Professor of Medicine (Geriatrics) and professor of epidemiology, Yale School of Public Health, and of investigative medicine at YSM, who leads the Yale Pepper Older Americans Independence Center.

Venture Investing To Catalyze The Next Generation Of Founder-Led, Longevity Biotech Companies — Dr. Alex Colville, Ph.D., Co-Founder and General Partner — age1.

Dr. Alex Colville, Ph.D. is Co-Founder and General Partner of age1 (https://age1.com/), a venture capital firm focused on catalyzing the next generation of founder-led, longevity biotech companies, with a strategy of building a community of visionaries advancing new therapeutics, tools, and technologies targeting aging and age-related diseases.

Continue reading “Dr. Alex Colville, Ph.D. — Co-Founder and General Partner — age1” »

150 YEARS MAXIMUM BIOLOGICAL AGE — “We observed, that the age-dependent population DOSI distribution broadening could be explained by a progressive loss of physiological resilience measured by the DOSI auto-correlation time. Extrapolation of this trend suggested that DOSI recovery time and variance would simultaneously diverge at a critical point of 120 − 150 years of age corresponding to a complete loss of resilience. The observation was immediately confirmed by the independent analysis of correlation properties of intraday physical activity levels fluctuations collected by wearable devices. We conclude that the criticality resulting in the end of life is an intrinsic biological property of an organism that is independent of stress factors and signifies a fundamental or absolute limit of human lifespan.”

We investigated the dynamic properties of the organism state fluctuations along individual aging trajectories in a large longitudinal database of CBC measurements from a consumer diagnostics laboratory. To simplify the analysis, we used a log-linear mortality estimate from the CBC variables as a single quantitative measure of aging process, henceforth referred to as dynamic organism state index (DOSI). We observed, that the age-dependent population DOSI distribution broadening could be explained by a progressive loss of physiological resilience measured by the DOSI auto-correlation time. Extrapolation of this trend suggested that DOSI recovery time and variance would simultaneously diverge at a critical point of 120 − 150 years of age corresponding to a complete loss of resilience. The observation was immediately confirmed by the independent analysis of correlation properties of intraday physical activity levels fluctuations collected by wearable devices. We conclude that the criticality resulting in the end of life is an intrinsic biological property of an organism that is independent of stress factors and signifies a fundamental or absolute limit of human lifespan.

P.O. Fedichev is a shareholder of Gero LLC. A.Gudkov is a member of Gero LLC Advisory Board. T.V. Pyrkov, K. Avchaciov, A.E. Tarkhov, L. Menshikov, and P.O. Fedichev are employees of Gero LLC.

Researchers at ETH Zurich recently identified a previously unknown compartment in mammalian cells. They have named it the exclusome. It is made up of DNA rings known as plasmids. The researchers have published details of their discovery in the journal Molecular Biology of the Cell.

The new compartment is in the cell plasma; it is previously uncharacterized in the literature. It is exceptional because eukaryotic cells (cells with nuclei) usually keep most of their DNA in the cell nucleus, where it is organized into chromosomes.

Some of the plasmids that end up in the exclusome originate from outside the cell, while others—known as telomeric rings—come from the capped ends of chromosomes, the telomeres. Particularly in certain cancer cells, the ones from the telomeres are regularly pinched off and joined together to form rings. However, these don’t contain the blueprints for proteins.

George Church at his most optimistic. June 1, 2022.

Dr George Church talks about combination therapies for age reversal, recently published papers from his lab and expresses his wish on developing inexpensive gene therapies like vaccine that can be equitably distributed to human.

Continue reading “Targeting A $2 Dose AGING REVERSAL Therapy For Everyone” »

If you believe the headlines, seaweeds can do almost anything from storing tons of carbon and stopping cows from belching methane, to making biofuels and renewable plastics – all while sustaining vibrant coastal ecosystems and feeding communities.

Add to that list their potential wound-healing properties and possible anti-aging effects, and it’s no wonder the seaweed farming industry is booming.

A new study adds to that fanfare, with lab experiments based on human-like skin cells revealing extracts from two brown seaweeds can inhibit reactions linked to skin aging and boost collagen levels.

Do you use biological age tests to quantify your fitness goals? I updated this piece with the latest products (there are a ton) and found a few discount codes too.

Update 10/2/2023: This post has been updated since we originally published it. I evaluated additional top biological age tests for 2024, removed companies that are no longer offering tests, and updated the post to reflect the most recent pricing. The post has been cleaned up and links were made current.

According to TikTok, I’m either 46-years-old, 37-years-old, or 29-years-old. As a 34-year-old woman, that’s, ahem, less than ideal.

Continue reading “11 Best Biological Age Tests for 2024” »

This is a ~50 minute talk by Michael Levin to a clinical audience about bioelectricity and why it represents a new approach to medicine.

Gene therapy company Genflow Biosciences has received positive feedback from Belgium’s Federal Agency for Medicines and Health Products as it seeks to move into human clinical trials. Genflow is developing gene therapies that target the aging process, with a focus on reducing and delaying age-related diseases.

Genflow’s approach involves the use of adeno-associated virus (AAV) vectors to deliver copies of the Sirtuin-6 (SIRT6) gene variant found in centenarians into cells. Sirtuins are a group of proteins that play a vital role in regulating various cellular processes. In recent years, SIRT6 has gained attention for its potential role in promoting healthy aging.

Genflow says it has received written advice from the FAHMP to commence clinical trials of its lead compound (GF-1002) in patients suffering from NASH, an aggressive form of non-alcoholic fatty liver disease, rather than in healthy volunteers. While further discussions and agreement with the European Medicine Agency (EMA) are still required, Genflow says that it expects a NASH clinical trial to commence in approximately 18 months.