Lifeboat Foundation

CRISPR gene editing already promises to fight diseases that were once thought unassailable, but techniques so far have required injecting the tools directly into affected cells. That’s not very practical for some conditions. However, there’s just been a breakthrough. NPR reports that researchers have published results showing that you can inject CRISPR-Cas9 into the bloodstream to make edits, opening the door to the use of gene editing for treating many common diseases.

The experimental treatment tackled a rare genetic disease, transthyretin amyloidosis. Scientists injected volunteers with CRISPR-loaded nanoparticles that were absorbed by the patients’ livers, editing a gene in the organ to disable production of a harmful protein. Levels of that protein plunged within weeks of the injection, saving patients from an illness that can rapidly destroy nerves and other tissues in their bodies.

The test involved just six people, and the research team still has to conduct long-term studies to check for possible negative effects. If this method proves viable on a large scale, though, it could be used to treat illnesses where existing CRISPR techniques aren’t practical, ranging from Alzheimer’s to heart disease.

👏😄We are rapidly approaching — from multiple directions of attack (pharmaceutical, nanotechnology, gene manipulation, etc) — the end of all forms of cancer, inherited diseases, even aging itself. It’s a great time to be alive IF you can live long enough to live forever(ish)! Which makes EVERY death that occurs in the meantime to be all the more of a punch to the gut and slap to the face. PARTICULARLY the 600 000 + people here in the US alone! It’s also another reason t… See More.

If the gene-editing tool CRISPR/Cas9 continues to show such promise it will herald a new era for the treatment of many genetic diseases.

Artificial kidneys, powerful batteries and efficient water purification are some of the future applications of a group of ultrathin materials known as MXenes. This opinion is expressed in an article in the journal Science, whose authors include one from Linköping University.

Materials that have a cross-section as thin as one or a few layers of atoms possess unusual properties due to their thickness. These properties may be high electrical conductivity, high strength or an ability to withstand heat, giving ultrathin materials a great potential for use in future technology. The most well-known material is graphene, and the hunt for other ultrathin materials, also known as two-dimensional materials, has increased in intensity since its discovery.

Graphene and many other two-dimensional materials are either semiconductors, semimetals or polarized insulators. The lack of an ultrathin metal conductor is an obstacle in the development of components based exclusively on two-dimensional materials.

Imagine clothing that can warm or cool you, depending on how you’re feeling. Or artificial skin that responds to touch, temperature, and wicks away moisture automatically. Or cyborg hands controlled with DNA motors that can adjust based on signals from the outside world.

Welcome to the era of intelligent matter—an unconventional AI computing idea directly woven into the fabric of synthetic matter. Powered by brain-based computing, these materials can weave the skins of soft robots or form microswarms of drug-delivering nanobots, all while reserving power as they learn and adapt.

Sound like sci-fi? It gets weirder. The crux that’ll guide us towards intelligent matter, said Dr. W.H.P. Pernice at the University of Munster and colleagues, is a distributed “brain” across the material’s “body”— far more alien than the structure of our own minds.

Engineers at Duke University have devised a system for manipulating particles approaching the miniscule 2.5 nanometer diameter of DNA using sound-induced electric fields. Dubbed “acoustoelectronic nanotweezers,” the approach provides a label-free, dynamically controllable method of moving and trapping nanoparticles over a large area. The technology holds promise for applications in the fields ranging from condensed matter physics to biomedicine.

The research appears online on June 22 in Nature Communications.

Precisely controlling nanoparticles is a crucial ability for many emerging technologies. For example, separating exosomes and other tiny biological molecules from blood could lead to new types of diagnostic tests for the early detection of tumors and neurodegenerative diseases. Placing engineered nanoparticles in a specific pattern before fixing them in place can help create new types of materials with highly tunable properties.

Circa 2020

Self-propelling magnetic nanorobots capable of intrinsic-navigation in biological fluids with enhanced pharmacokinetics and deeper tissue penetration implicates promising strategy in targeted cancer therapy. Here, multi-component magnetic nanobot designed by chemically conjugating magnetic Fe3O4 nanoparticles (NPs), anti-epithelial cell adhesion molecule antibody (anti-EpCAM mAb) to multi-walled carbon nanotubes (CNT) loaded with an anticancer drug, doxorubicin hydrochloride (DOX) is reported. Autonomous propulsion of the nanobots and their external magnetic guidance is enabled by enriching Fe3O4 NPs with dual catalytic-magnetic functionality. The nanobots propel at high velocities even in complex biological fluids. In addition, the nanobots preferably release DOX in the intracellular lysosomal compartment of human colorectal carcinoma (HCT116) cells by the opening of Fe3O4 NP gate.

Physics World

Experiment shows that classical clocks exhibit the same relationship between entropy and accuracy as their quantum counterparts.

Light-driven molecular motors have been around for over 20 years. These motors typically take microseconds to nanoseconds for one revolution. Thomas Jansen, associate professor of physics at the University of Groningen, and Master’s student Atreya Majumdar have now designed an even faster molecular motor. The new design is driven by light only and can make a full turn in picoseconds using the power of a single photon. Jansen says, “We have developed a new out-of-the-box design for a motor molecule that is much faster.” The design was published in The Journal of Physical Chemistry Letters on 7 June.

The new motor molecule design started with a project in which Jansen wanted to understand the energy landscape of excited chromophores. “These chromophores can attract or repel each other. I wondered if we could use this to make them do something,” explains Jansen. He gave the project to Atreya Majumdar, then a first-year student in the Top Master’s degree program in Nanoscience in Groningen. Majumdar simulated the interaction between two chromophores that were connected to form a single molecule.

Nanobots, tiny nano-sized robots and vehicles that can navigate through blood vessels to reach the site of a disease could be used to deliver drugs to tumours that are otherwise difficult to treat.

Once injected or swallowed, most drugs rely upon the movement of body fluids to find their way around the body. It means that some types of disease can be difficult to treat effectively in this way.

One aggressive type of brain tumour known as glioblastoma, for example, kills hundreds of thousands of people a year. But because it produces finger-like projections into a patient’s brain tissue that damage the blood vessels around them, it is hard for drugs to reach the tumour site.