Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: nanotechnology – Page 16

Nonlinear sound-sheet microscopy

Key to this innovation in ultrasound imaging—a method called Nonlinear sound sheet microscopy —was the discovery of a sound-reflecting probe. The author said: “This probe is a nanoscale gas-filled vesicle that lights up in ultrasound images, making cells visible. These vesicles have a protein shell and we can engineer them to tune their brightness in images. We used these gas vesicles to track cancer cells.”

In addition to revealing cells, the team used ultrasound and microbubbles as probes circulating in the blood stream to detect brain capillaries. The author said: “To our knowledge, nonlinear sound sheet microscopy is the first technique capable of observing capillaries in living brains. This breakthrough has tremendous potential to diagnose small vessel diseases in patients.” Since microbubble probes are already approved for human use, this technique could be deployed in hospitals in a few years.

Ultrasound is one of the most widely used imaging techniques in medicine, but up until recently it hardly played a role in imaging the tiniest structures of our bodies such as cells. “Clinical ultrasound, like the kind used for pregnancy scans, creates real-time images of body parts”, the first author explains. “It allows diagnosis of various diseases, or to monitor a developing baby. However, what is going on at a microscopic level remains hidden.”

Now, a team of scientists managed to image specifically labelled cells in 3D with ultrasound. For the first time, they imaged living cells inside whole organs across volumes the size of a sugar cube. In comparison, current light-based microscopes often require imaging of non-living samples, the author says. “The sample or organ of interest has to be removed and processed, and you lose the ability to track activity of cells over time”

Aiming for Lighter Light Sails

Norte and his colleagues initially considered patterning the light sails with an array of identical circular holes, but such a pattern would reduce the overall effect of the powering laser. As the sail speeds up and moves away from the laser, the wavelength it preferentially reflects will shift because of the Doppler effect, and the sail will subsequently receive less of a push. What is needed instead is a pattern that can handle Doppler-shift changes while remaining highly reflective.

To find the optimal pattern, the researchers turned to a neural network, which predicted an optimal shape that is oblong rather than circular. “It looks like a potato,” says Miguel Bessa of Brown University, Rhode Island, who led the theory side of the project. Specifically, the team arranged several potato shapes in a repeating five-neighbor pattern, or pentagonal lattice. The potato-shaped arrangement allows the system to respond to a broader range of wavelengths without having to make it thicker and thus heavier.

The researchers are now working on increasing the size of their sail and looking into ways to test how well it flies. Norte notes that the light sail is just a means to accelerate the nanospacecraft, which will include a microchip, cameras, and other instruments. All those parts need to be miniaturized so that they weigh less than one gram total. “We are really trying to use nanotechnology to go faster and further than we have been able to with traditional spacecraft,” Norte says.

Defying Thermal Limits: Scientists Create a New, Ultra-Strong, Heat-Resistant Material

A breakthrough Cu-Ta-Li alloy has the potential to revolutionize aerospace, defense, and industrial applications. Researchers from the U.S. Army Research Laboratory (ARL) and Lehigh University have developed an advanced nanostructured copper alloy that sets a new benchmark for high-temperature perf

Combining polarized light methods reveals hidden molecular orientations with precision

Image quality often makes the difference between an amazing multimedia experience, like feeling immersed in a high-definition movie, and a visual letdown. When it comes to biomolecular imaging, the details matter even more. When scientists increase resolution in quantitative imaging, they improve accuracy and confidence in results, ultimately facilitating discoveries in studies of proteins, cells and other biomedical applications.

Scientists have long been able to look at to study their nanoscale structures and dynamics in . However, distinguishing between two closely spaced dipole emitters, which are that can emit light in specific directions and intensities, has remained a major challenge, especially when such molecules emit light at the same time and are spatially coincident, or located at nearly the same point in space.

This limitation has hindered researchers’ ability to measure the orientation and angular separation of dipoles accurately, which is vital to understanding their rotational dynamics in crowded cellular environments.

Engineers develop a way to mass manufacture nanoparticles that deliver cancer drugs directly to tumors

Polymer-coated nanoparticles loaded with therapeutic drugs show significant promise for cancer treatment, including ovarian cancer. These particles can be targeted directly to tumors, where they release their payload while avoiding many of the side effects of traditional chemotherapy.

Over the past decade, MIT Institute Professor Paula Hammond and her students have created a variety of these particles using a technique known as layer-by-layer assembly. They’ve shown that the particles can effectively combat cancer in mouse studies.

To help move these nanoparticles closer to human use, the researchers have now come up with a manufacturing technique that allows them to generate larger quantities of the particles, in a fraction of the time.

Investigating the effect of heterogeneities across the electrode|multiphase polymer electrolyte interfaces in high-potential lithium batteries Nanotechnology

X-ray synchrotron measurements reveal heterogeneities at electrode|electrolyte interfaces of lithium metal batteries operating at high potentials. Here the authors demonstrate the rearrangement of ionically conductive phases in polymer electrolytes that lead to battery performance degradation.

Enhancing immunotherapy with tumour-responsive nanomaterials

Immunotherapies, predominantly immune-checkpoint inhibitors and chimaeric antigen receptor T cells, have transformed oncology. Nonetheless, these systemically administered agents have several limitations, including the risk of off-target toxicities and a lack of activity owing to an inability to overcome an immunosuppressive tumour microenvironment (TME). In this Review, the authors describe the potential to overcome these challenges using functionalized nanomaterials that are designed to release a wide range of immunotherapeutic cargoes in response to specific TME characteristics, including hypoxia, differences in pH, the presence of specific enzymes, reactive oxygen species and/or high levels of extracellular ATP.

Breakthrough Lightsail: Ultra-Thin, AI-Optimized, and Ready to Race to Alpha Centauri

A new collaboration between Brown University and TU Delft has brought us closer to interstellar travel using light-powered sails. By combining ultra-thin, highly reflective materials with AI-optimized nanoscale design, researchers created a revolutionary lightsail that’s cheaper, faster to make.

Researchers develop 90-nanometer LEDs for future ultra high-resolution displays

These nano-PeLEDs feature pixel lengths as small as 90 nanometers, enabling an unprecedented pixel density of 127,000 pixels per inch (PPI). For comparison, a typical 27-inch 4K gaming monitor has a pixel density of just 163 PPI.

“Making electronic devices smaller is an everlasting pursuit for scientists and engineers,” said Professor Di Dawei, Deputy Director of the International Research Center for Advanced Photonics at Zhejiang University.

He explained that while micro-LEDs based on III-V semiconductors are considered state-of-the-art, their efficiency drops sharply when pixel sizes fall below 10 micrometers – a limitation that has hindered their use in ultra-high-resolution displays.