Lifeboat Foundation

The innovation – which has undergone advanced pre-clinical trials – is effective against a broad range of drug-resistant bacterial cells, including ‘golden staph’, which are commonly referred to as superbugs.

Antibiotic resistance is a major global health threat, causing about 700,000 deaths annually, a figure which could rise to 10 million deaths a year by 2050 without the development of new antibacterial therapies.

The new study led by RMIT University and the University of South Australia (UniSA) tested black phosphorus-based nanotechnology as an advanced infection treatment and wound healing therapeutic.

Continue reading “Ultrathin nanotech promises to help tackle antibiotic resistance” »

Scientists at the Indian Institute of Science (IISc) have developed a new approach to potentially detect and kill cancer cells, especially those that form a solid tumor mass. They have created hybrid nanoparticles made of gold and copper sulfide that can kill cancer cells using heat and enable their detection using sound waves, according to a study published in ACS Applied Nano Materials.

Early detection and treatment are key in the battle against cancer. Copper sulfide nanoparticles have previously received attention for their application in cancer diagnosis, while gold nanoparticles, which can be chemically modified to target cancer cells, have shown anticancer effects. In the current study, the IISc team decided to combine these two into hybrid nanoparticles.

“These particles have photothermal, oxidative stress, and photoacoustic properties,” says Jaya Prakash, Assistant Professor at the Department of Instrumentation and Applied Physics (IAP), IISc, and one of the corresponding authors of the paper. Ph.D. students Madhavi Tripathi and Swathi Padmanabhan are co-first authors.

We could soon see more lithium-ion batteries made with recycled materials thanks to a new partnership. BASF, a battery materials producer, has announced that it’s teaming up with Nanotech Energy, a maker of graphene-based energy products, to produce lithium-ion batteries with recycled materials for customers in North America.

While BASF will create the cathode active materials using recycled metals from a Battle Creek, Michigan facility, Nanotech will use those materials to create the lithium-ion battery cells. Making the batteries with recycled metals could decrease their CO₂ footprint by around 25 percent, according to BASF.

Additionally, BASF and Nanotech Energy will also work with the American Battery Technology Company (ABTC) and the Canada-based TODA Advanced Materials Inc. ABTC will recycle the materials gathered by Nanotech, such as nickel, cobalt, manganese, and lithium. TODA will then use the materials to create battery precursors, which BASF will then convert into cathode active materials.

Another excellent paper from Johann G. Danzl’s research group. They develop methods that combine novel negative staining techniques, deep learning, and super-resolution STED microscopy or expansion microscopy to facilitate nanoscale-resolution imaging of brain tissue volumes. They also show semi-automated (and some fully automated) segmentation of neuron morphology and identification of synapses. Very cool work and I’m excited to see how it influences connectomics in the future! #brain #neuroscience #imaging #microscopy #neurotech

Mapping fixed brain samples with extracellular labeling and optical microscopy reveals synaptic connections.

An international research team headed by Johannes Karges, PhD, of the faculty of chemistry and biochemistry at Ruhr University Bochum, Germany, has developed nanoparticles that accumulate in cancer cells and eliminate them after being photoactivated. The research team also labeled them in such a way that immune cells learn to eliminate similar cells throughout the body which could even mean undetected metastases can be treated.

The researchers presented their findings in the journal Nature Communications in an article titled, “Theranostic imaging and multimodal photodynamic therapy and immunotherapy using the mTOR signaling pathway.”

“Tumor metastases are considered the leading cause of cancer-associated deaths,” the researchers wrote. “While clinically applied drugs have demonstrated to efficiently remove the primary tumor, metastases remain poorly accessible. To overcome this limitation, herein, the development of a theranostic nanomaterial by incorporating a chromophore for imaging and a photosensitizer for treatment of metastatic tumor sites is presented. The mechanism of action reveals that the nanoparticles are able to intervene by local generation of cellular damage through photodynamic therapy as well as by systemic induction of an immune response by immunotherapy upon inhibition of the mTOR signaling pathway which is of crucial importance for tumor onset, progression, and metastatic spreading.”

A new neural cell type with astrocyte characteristics and the molecular machinery for synaptic transmission has been discovered.

A group of 12 researchers at Rice University in Houston have used 3D printing to create near-bulletproof material made out of plastic. The novel materials can withstand being shot at by bullets traveling at 5.8 kilometers per second and are highly compressible without falling apart.

Tubulanes are theoretical microscopic structures comprised of crosslinked carbon nanotubes and the researchers sought to test if they would have the same properties when scaled up enough to be 3D printed. It turns out they did.

The researchers proved this by shooting a bullet traveling at 5.8 kilometers per second through two cubes. One cube was made from a solid polymer and the other from a polymer printed with a tubulane structure.

Continue reading “Researchers 3D Print Bulletproof Plastic Layered Cubes” »

Osteoarthritis (OA) is a prevalent global health concern, posing a significant and increasing public health challenge worldwide. Recently, biomaterials have emerged as a highly promising strategy for OA therapy due to their exceptional physicochemical properties and capacity to regulate pathological processes. However, there is an urgent need for a deeper understanding of the potential therapeutic applications of these biomaterials in the clinical management of diseases, particularly in the treatment of OA. In this comprehensive review, we present an extensive discussion of the current status and future prospects concerning biomaterials for OA… More.

Herein, in this review, we summarize the advanced strategies developed for enhancing OA therapy based on the biomaterials. We conducted a comprehensive literature search using relevant databases such as PubMed, Scopus, and Web of Science. The search was focused on peer-reviewed articles and research papers published within the last ten years (from 2013 to 2023). We utilized specific keywords related to biomaterials”, biomaterials” and “osteoarthritis therapy” to retrieve relevant studies. First, we provide an overview of the pathophysiology of OA and the limitations of current treatment options. Second, we explore the various types of biomaterials which have been used for OA therapy, including nanoparticles, nanofibers, and nanocomposites. Third, we highlight the advantages and challenges associated with the use of biomaterials in OA therapy, such as toxicity, biodegradation, and regulatory issues. Finally, advanced biomaterials-based OA therapies with their potential for clinical translation and emerging biomaterials directions for OA therapy are discussed.

Characteristics of Biomaterials

Nanotechnology-boosted biomaterials have attracted considerable attention in recent years as promising candidates for revolutionizing the field of therapeutics.^12,13 These materials combine the unique properties of nanotechnology with the versatility and biocompatibility of biomaterials, offering numerous advantages over existing therapeutic approaches. Nanotechnology enables the precise engineering of biomaterials at the nanoscale, allowing for the encapsulation and controlled release of therapeutic agents, such as drugs and growth factors.^14–17 This feature facilitates targeted and sustained drug delivery to specific sites within the body, reducing systemic side effects and enhancing treatment efficacy. In the context of OA, this targeted drug delivery can be utilized to deliver anti-inflammatory agents or disease-modifying drugs directly to affected joint tissues, promoting tissue repair and alleviating symptoms. Furthermore, biomaterials can be designed to mimic the native tissue environment, thereby enhancing their biocompatibility and reducing the risk of adverse reactions or immune responses.¹⁸ This characteristic is crucial for successful integration and long-term functionality of biomaterials in biomedical applications. Moreover, nanomaterials can facilitate tissue regeneration by stimulating cellular responses and promoting tissue growth.¹⁹ In the context of OA, biomaterials can assist in cartilage repair and regeneration, potentially slowing down disease progression and improving joint function.³ In addition, nanotechnology allows for the customization of biomaterials with a wide range of physical, chemical, and biological properties.¹³ This flexibility enables the development of multifunctional biomaterials that can simultaneously perform multiple tasks, such as drug delivery, imaging, and tissue regeneration. These advantages collectively contribute to their potential as innovative solutions in addressing various biomedical challenges and improving patient outcomes. In this section, we will discuss some of the key properties of biomaterials and their impact on OA treatment.

Continue reading “Nanotechnology-Boosted Biomaterials for Osteoarthritis” »

Metalens for AR and VR.

BEIJING, Sept. 8, 2023 /PRNewswire/ — WiMi Hologram Cloud Inc. (NASDAQ: WIMI) (“WiMi” or the “Company”), a leading global Hologram Augmented Reality (“AR”) Technology provider, today announced that a metasurface eyepiece for augmented reality has been developed, which is based on metasurfaces composed of artificially fabricated subwavelength structures. The metasurface eyepiece employs a special optical design and engineered anisotropic optical response to achieve an ultra-wide field of view(FOV), full-color imaging, and high-resolution near-eye display.

At the heart of the WiMi’s metalens are see-through metalens with a high numerical aperture(NA), a large area and broadband characteristics. Its anisotropic optical response allows it to perform two different optical functions simultaneously. First, it can image virtual information, acting as an imaging lens for virtual information. Second, it can transmit light, serving as a transparent glass for viewing a real-world scene. This design allows the transparent metalens to be placed directly in front of the eye without the need for additional optics, resulting in a wider FOV.

Fabrication of metalens is done using nanoimprinting technology, which is capable of fabricating large-area metalens with sub-wavelength structures. First, a mould or template with the desired structure is prepared. Then, the mould or template is contacted with a transparent substrate and the nanoscale structure is transferred by applying pressure and temperature. Through this nanoimprinting process, the subwavelength structure of the metalens is successfully replicated onto the transparent substrate, resulting in the formation of the metalens.

Continue reading “WiMi Developed Metasurface Eyepiece for Augmented Reality with Ultra-wide FOV” »