Lifeboat Foundation

Human stem cells have shown potential in medicine as they can transform into various specialized cell types such as bone and cartilage cells. The current approach to obtain such specialized cells is to subject stem cells to specialized instructive protein molecules known as growth factors. However, use of growth factors in the human body can generate harmful effects including unwanted tissue growth, such as a tumor.

Researchers at Texas A&M University have explored a new class of clay nanoparticles that can direct stem cells to become bone or cartilage cells.

Dr. Akhilesh Gaharwar, an assistant professor in the Department of Biomedical Engineering, and his students have demonstrated that a specific type of two-dimensional (2-D) nanoparticles, also known as nanosilicates, can grow bone and cartilage tissue from stem cells in the absence of growth factors. These nanoparticles are similar to flaxseed in shape, but 10 billion times smaller in size. Their work, “Widespread changes in transcriptome profile of human mesenchymal stem cells induced by two-dimensional nanosilicates,” has been published in Proceedings of the National Academy of Sciences this week.

Continue reading “Flaxseed-like particles can now grow bone, cartilage tissues for humans” »

Trapping light with an optical version of a whispering gallery, researchers at the National Institute of Standards and Technology (NIST) have developed a nanoscale coating for solar cells that enables them to absorb about 20 percent more sunlight than uncoated devices. The coating, applied with a technique that could be incorporated into manufacturing, opens a new path for developing low-cost, high-efficiency solar cells with abundant, renewable and environmentally friendly materials.

The coating consists of thousands of tiny glass beads, only about one-hundredth the width of a human hair. When sunlight hits the coating, the light waves are steered around the nanoscale bead, similar to the way sound waves travel around a curved wall such as the dome in St. Paul’s Cathedral in London. At such curved structures, known as acoustic whispering galleries, a person standing near one part of the wall easily hears a faint sound originating at any other part of the wall.

Whispering galleries for light were developed about a decade ago, but researchers have only recently explored their use in solar-cell coatings. In the experimental set up devised by a team including Dongheon Ha of NIST and the University of Maryland’s NanoCenter, the light captured by the nanoresonator coating eventually leaks out and is absorbed by an underlying solar cell made of gallium arsenide.

Imagine a single particle, only one-tenth the diameter of a bacterium, whose miniscule jiggles induce sustained vibrations in an entire mechanical device some 50 times larger. By taking clever advantage of the interplay between light, electrons on the surface of metals, and heat, researchers at the National Institute of Standards and Technology (NIST) have for the first time created a plasmomechanical oscillator (PMO), so named because it tightly couples plasmons—the collective oscillations of electrons at the surface of a metal nanoparticle—to the mechanical vibrations of the much larger device it’s embedded in.

The entire system, no bigger than a red blood cell, has myriad technological applications. It offers new ways to miniaturize mechanical oscillators, improve communication systems that depend on the modulation of light, dramatically amplify extremely weak mechanical and electrical signals and create exquisitely sensitive sensors for the tiny motions of nanoparticles.

NIST researchers Brian Roxworthy and Vladimir Aksyuk described their work in a recent issue of Optica.

Hedrick’s close call inspired his research team to design a new molecule, called a polymer, that targets five deadly types of drug-resistant microbes and kills them like ninja assassins. Their research, a collaboration with Singapore’s Institute of Bioengineering and Nanotechnology, was reported recently in the journal Nature Communications.

If commercialized, the polymer could boost the fight against “superbugs” that can fend off every antibiotic that doctors throw at them. An estimated 700,000 people worldwide die every year from these untreatable infections.

YES!!!

Scientists at the Department of Energy’s National Renewable Energy Laboratory (NREL) have discovered a new approach for developing a rechargeable non-aqueous magnesium-metal battery.

A proof-of-concept paper published in Nature Chemistry detailed how the scientists pioneered a method to enable the reversible chemistry of magnesium metal in the noncorrosive carbonate-based electrolytes and tested the concept in a prototype cell. The technology possesses potential advantages over lithium-ion batteries—notably, higher energy density, greater stability, and lower cost.

Continue reading “Research overcomes major technical obstacles in magnesium-metal batteries” »

Nanobots could provide cancer treatment free from side effects.

Advocates of transhumanism face a similar choice today. One option is to take advantage of the advances in nanotechnologies, genetic engineering and other medical sciences to enhance the biological and mental functioning of human beings (never to go back). The other is to legislate to prevent these artificial changes from becoming an entrenched part of humanity, with all the implied coercive bio-medicine that would entail for the species.

We can either take advantage of advances in technology to enhance human beings (never to go back), or we can legislate to prevent this from happening.

Continue reading “Transhumanism: advances in technology could already put evolution into hyperdrive – but should they?” »

Doctors have been using radiation to treat cancer for more than a hundred years, but it’s always been a delicate art to direct treatment while avoiding healthy tissue.

To help them, scientists with the University of Chicago have designed an army of tiny flower-shaped metal-and-organic nanoparticles that deliver a one-two punch—first boosting the effects of radiation at the tumor site and then jumpstarting the immune system to search out any remaining tumors.

The research, published March 26 in Nature Biomedical Engineering, led to a candidate molecule currently beginning phase 1 clinical trials.

Continue reading “Scientists build army of metal-organic nanoflowers to treat cancer” »

Making a giant leap in the ‘tiny’ field of nanoscience, a multi-institutional team of researchers is the first to create nanoscale particles composed of up to eight distinct elements generally known to be immiscible, or incapable of being mixed or blended together. The blending of multiple, unmixable elements into a unified, homogenous nanostructure, called a high entropy alloy nanoparticle, greatly expands the landscape of nanomaterials—and what we can do with them.

This research makes a significant advance on previous efforts that have typically produced nanoparticles limited to only three different elements and to structures that do not mix evenly. Essentially, it is extremely difficult to squeeze and blend different elements into individual particles at the nanoscale. The team, which includes lead researchers at University of Maryland, College Park (UMD)’s A. James Clark School of Engineering, published a peer-reviewed paper based on the research featured on the March 30 cover of Science.

“Imagine the elements that combine to make nanoparticles as Lego building blocks. If you have only one to three colors and sizes, then you are limited by what combinations you can use and what structures you can assemble,” explains Liangbing Hu, associate professor of materials science and engineering at UMD and one of the corresponding authors of the paper. “What our team has done is essentially enlarged the toy chest in nanoparticle synthesis; now, we are able to build nanomaterials with nearly all metallic and semiconductor elements.”