Lifeboat Foundation

You can’t peer very far down into a well or below the surface of the ocean before things go dark—light does not penetrate to such depths. Though the brain is far from bottomless, neuroscientists face the same lack of light when they try to study living deep-brain structures. This is especially frustrating given that optogenetics, a method for manipulating genetically tagged brain cells with light, has exploded in popularity over the past decade. “Optogenetics has been a revolutionary tool for controlling neurons in the lab, and hopefully someday in the clinic,” says Thomas McHugh, research group leader at the RIKEN Brain Science Institute in Japan. “Unfortunately, delivering light within brain tissue requires invasive optical fibers.”

McHugh and colleagues now have a solution for sending light to new depths in the brain. As they report in Science on February 9, upconversion nanoparticles (UCNPs) can act as a conduit for laser light delivered from outside the skull. These nanoparticles absorb near-infrared laser light and in turn emit visible photons to areas that are inaccessible to standard optogenetics. This method was used to turn on neurons in various brain areas as well as silence seizure activity and evoke memory cells. “Nanoparticles effectively extend the reach of our lasers, enabling the ‘remote’ delivery of light and potentially leading to non-invasive therapies,” says McHugh.

In optogenetics, blue-green light is used to turn neurons on or off via light-responsive ion channels. Light at these wavelengths, however, scatters strongly and is at the other end of the spectrum from the near-infrared light that can penetrate deeper into brain tissue. UCNPs composed of elements from the lanthanide family can act as a bridge. Their ‘optogenetic actuation’ turns low-energy near-infrared laser light into blue or green wavelengths for control of specifically labeled cells. Though such bursts of light deliver considerable energy to a small area, temperature increases or cellular damage were not observed.

Continue reading “Nanoparticles Enable Non-Invasive Optogenetic Control of Brain Cell Activity With Near-Infrared Light” »

Spin a merry-go-round fast enough and the riders fly off in all directions. But the spinning particles in a Rice University lab do just the opposite.

Experiments in the Rice lab of chemical engineer Sibani Lisa Biswal show micron-sized spheres coming together under the influence of a rapidly spinning magnetic field. That’s no surprise because the particles themselves are magnetized.

Continue reading “Fast-spinning spheres show nanoscale systems’ secrets” »

Credit: University of New Mexico For years, scientists have long wrestled with the control and manipulation of light, a long-standing scientific ambition with major implications for the development of technology. With the growth in nanophotonics, scientists are making gains faster than ever exploiting structures with dimensions comparable to the wavelength of light. Scientists at The University of New Mexico studying the field of nanophotonics are developing new perspectives never seen before through their research. In turn, the understanding of these theoretical concepts is enabling physic…

Many of the previously dumb devices in our homes are getting smarter with the advent of internet-connected lights, thermostats, and more. Surely the windows can’t be smart, can they? A team of engineers from the German Friedrich-Schiller University Jena have created just that — a smart window that can alter its opacity and harvest energy from the sun’s rays.

There have been a number of “smart” electrochromatic window designs over the years, but these are mostly aimed at changing tint or opacity only. The windows designed by Friedrich-Schiller University researchers are vastly more functional. The so-called Large-Area Fluidic Windows (LaWin) design uses a fluid suspension of iron particles. This fluid is contained within the window in a series of long vertical channels. These “functional fluids” allow the window to change opacity, but also absorb and distribute heat.

The iron-infused fluid remains diffused until you switch the window on — the nanoparticles cloud up the channels and block light. When you flip the switch, magnets drag the nanoparticles out of the liquid to make the window fully transparent. When the magnet is switched off, the nanoparticles are resuspended to darken the panel. In general, the more nanoparticles you add, the darker the window becomes. You can even completely black it out with enough iron.

Continue reading “Smart Windows Use Iron Nanoparticles to Harvest Heat” »

Looking back at best of 2017)

Summary: Nanotechnology meets gene editing. MIT researchers use nanoparticles instead of viruses to deliver the CRISPR gene editing system. This article first appeared on LongevityFacts. Author: Brady Hartman]

In a new study, MIT scientists have developed nanoparticles that deliver the CRISPR gene editing system, eliminating the need to use viruses for delivery.

Continue reading “Revolutionary CRISPR Gene Editing with Nanoparticles” »

Why aren’t holograms or related optical devices part of our everyday lives yet? The technologies can be created by using magnetic fields to alter the path of light, but the materials that can do that are expensive, brittle and opaque. Some only work in temperatures as cold as the vacuum of space.

Minjeong Cha, MSE PhD Student, applies a gel made up of chiromagnetic nanoparticles that are a conduit for modulating light to a laser apparatus. Image credit: Joseph Xu, Michigan Engineering

Continue reading “Nanoparticle gel could make mass-market low-cost Holography, LIDAR” »

A DNA machine with a high-speed arm could pave the way for nanoscale factories.

The dozen people working at CSER itself—little more than a large room in an out-of-the-way building near the university’s occupational health service—organize talks, convene scientists to discuss future developments, and publish on topics from regulation of synthetic biology to ecological tipping points. A lot of their time is spent pondering end-of-the-world scenarios and potential safeguards.

A small cadre of scientists worries that lab-made viruses, AI, or nanobots could drive humans to extinction.

Continue reading “Could science destroy the world? These scholars want to save us from a modern-day Frankenstein” »

Dennis Kowalski, the president of Cryonics Institute in the United States, has made the incredible announcement that cryonics is advancing so fast that he is unable to keep up with the demand for it. The institute spearheads the process of freezing human beings by cryogenics.

Dennis spoke exclusively and said that technology is making huge advances and went on to talk about CPR and said that it would have seemed not possible only 100 years ago. He said that today people take technology for granted. Dennis used to work as a paramedic and said that the reason he got into cryogenics was thanks to a book with the title of Engines of Creation by J Robert Freitas which has the focus on nanotechnology.

Continue reading “First Human FROZEN” »