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A Virginia 14-year-old won $25,000 and earned the title of America’s Top Young Scientist this past fall for developing an affordable soap that can treat skin cancer. Heman Bekele plans to refine his invention over the next five years and create a nonprofit to distribute it in low-income communities.

The ninth grader spent four months competing against nine other finalists in 3M and Discovery Education’s Young Scientist Challenge, which encourages kids to “think creatively and apply the power of STEM to discover real-world solutions.” He was paired with a mentor, who helped him turn his idea into a prototype. It works by delivering cancer-fighting agents to the skin by way of lipid nanoparticles.

Bekele told NPR that he’s “always been really passionate about science and how things work,” and his experience growing up in Ethiopia inspired him to develop his soap.

A new peptide-carrying magnetic nanoparticle described in Science Advances has resolved both biological and behavioral symptoms in mouse models of Alzheimer’s disease.

A short peptide disassembles stable pathogenic tau fibrils of Alzheimer’s disease.

Ohh nice! New vaccine science it seems though I’m not familiar with vaccines, this does seem like a novel approach. It’s kinda future proof to train the immune system to target proteins that are shared across all coronavirus’ I’m hoping it provides, as do they, that it provides a better solution than current vaccines.

The vaccine is made by attaching harmless proteins from different coronaviruses to minuscule nanoparticles that are then injected to prime the body’s defences to fight the viruses should they ever invade.

Because the vaccine trains the immune system to target proteins that are shared across many different types of coronavirus, the protection it induces is extremely broad, making it effective against known and unknown viruses in the same family.

Continue reading “Scientists create vaccine with potential to protect against future coronaviruses” »

Excellent paper wherein Shen et al.

Abstract. Long single-stranded DNA (ssDNA) is a versatile molecular reagent with applications including RNA-guided genome engineering and DNA nanotechnology, yet its production is typically resource-intensive. We introduce a novel method utilizing an engineered Escherichia coli ‘helper’ strain and phagemid system that simplifies long ssDNA generation to a straightforward transformation and purification procedure. Our method obviates the need for helper plasmids and their associated contamination by integrating M13mp18 genes directly into the E. coli chromosome. We achieved ssDNA lengths ranging from 504 to 20 724 nt with titers up to 250 μg/l following alkaline lysis purification. The efficacy of our system was confirmed through its application in primary T-cell genome modifications and DNA origami folding. The reliability, scalability and ease of our approach promise to unlock new experimental applications requiring large quantities of long ssDNA.

Center for natural and artificial intelligence.

The interest in antimicrobial solutions for personal and multi-user touch screens, such as tablets and mobile devices, has grown in recent years. Traditional methods like sprayable alcohols or wipes are not ideal for these delicate displays. Antimicrobial coatings applied directly to the glass are a promising alternative, but only if they are transparent and long-lasting.

A research team at the University of Pittsburgh led by Alexander Star, a chemistry professor in the Kenneth P. Dietrich School of Arts and Sciences, has developed a fentanyl sensor that is six orders of magnitude more sensitive than any electrochemical sensor for the drug reported in the past five years. The portable sensor can also tell the difference between fentanyl and other opioids.

Many pancreatic tumors are like malignant fortresses, surrounded by a dense matrix of collagen and other tissue that shields them from immune cells and immunotherapies that have been effective in treating other cancers. Employing bacteria to infiltrate that cancerous fortification and deliver these drugs could aid treatment for pancreatic cancer, according to newly published findings from a team of University of Wisconsin–Madison researchers.

From DNA nanotechnology to synthetic biology.

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