Over the past decade, experts in the field of nanotechnology and materials science have been trying to devise architectures composed of small structures that spontaneously arrange themselves following specific patterns. Some of these architectures are based on so-called icosahedral shells, structures with 20 different triangular phases that are symmetrically organized.
New research led by the University of Cambridge, in collaboration with Hong Kong University of Science and Technology (GZ) and Queen Mary University of London, could redefine how we interact with everyday tools and devices—thanks to a novel method for printing ultra-thin conductive microfibers.
Imagine fibers thinner than a human hair (nano-to micro-scale in diameter) that can be tuned on-demand to add sensing, energy conversion and electronic connectivity capabilities to objects of different shapes and surface textures (such as glass, plastic and leather). This is what the researchers have achieved, including in unconventional materials like porous graphene aerogels, unlocking new possibilities for human-machine interaction in various everyday settings.
The researchers present a one-step adaptive fiber deposition process using 3Dprinting, set up to satisfy the fast-changing demands of users. The process enables the on-demand deployment of conductive material layers on different surface areas, dependent on the model’s geometry, at the point of use. The findings are reported in the journal Advanced Fiber Materials.
Abdominal pain is a hallmark of many digestive disorders, including inflammatory bowel disease and irritable bowel syndrome. In an effort to develop targeted treatments for gut pain, scientists have discovered a new enzyme in gut bacteria and are using nanoparticles to deliver drugs inside cells.
Currently, there are no treatments specifically for gut pain, and existing painkillers are often insufficient at managing symptoms. These drugs—including opioids, NSAIDs, and steroids—also come with side effects, some of which directly harm the digestive system.
In two new studies published in Cell Host & Microbe and Proceedings of the National Academy of Sciences, researchers focused on PAR2, a receptor involved in pain signaling that has been shown to play a role in gastrointestinal diseases marked by inflammation and pain. Found on the lining of the gut and on pain-sensing nerves in the gut, PAR2 is activated by certain enzymes called proteases and is a promising target for treating gut pain—in numerous ways.
An international team of researchers has developed a novel technique to efficiently excite and control highly-confined light-matter waves, known as higher-order hyperbolic phonon polaritons. Their method not only sets new records for the quality and propagation distance of these waves but also uses a sharp boundary to create a form of pseudo-birefringence, sorting and steering the waves by mode into different directions.
This advance, published in Nature Photonics, opens new avenues for developing nanoscale optical devices for high-speed signal processing and ultra-sensitive chemical detection.
In the quest for ultra-compact, light-based circuits, scientists are turning to polaritons—hybrid modes formed from the coupling of light with optically active material excitations such as plasmons or phonons. These remarkable quasiparticles can squeeze light into spaces far smaller than its natural wavelength, overcoming the conventional limits of far-field optics. However, exciting most confined variants—higher-order polaritons—has been a major challenge, as they demand a much larger momentum boost than single-step excitation methods can deliver.
Turning a biologically important molecular motor at a constant rate saves energy, according to experiments.
Within every biological cell is an enzyme, called adenosine triphosphate (ATP) synthase, that churns out energy-rich molecules for fueling the cell’s activity. New experiments investigate the functioning of this “energy factory” by artificially cranking one of the enzyme’s molecular motors [1]. The results suggest that maintaining a fixed rotation rate minimizes energy waste caused by microscopic fluctuations. Future work could confirm the role of efficiency in the evolutionary design of biological motors.
ATP synthase consists of two rotating molecular motors, Fo and F1, that are oriented along a common rotation axis and locked together so that the rotation of Fo exerts a torque on the shaft in the middle of F1. The resulting motion within F1 helps bring together the chemical ingredients of the molecule ATP, which stores energy that can later be used in cellular processes.
A research team co-led by the Institute for Bioengineering of Catalonia (IBEC) and West China Hospital Sichuan University (WCHSU), working with partners in the UK, has demonstrated a nanotechnology strategy that reverses Alzheimer’s disease in mice.
Unlike traditional nanomedicine, which relies on nanoparticles as carriers for therapeutic molecules, this approach employs nanoparticles that are bioactive in their own right: “supramolecular drugs.” The work has been published in Signal Transduction and Targeted Therapy.
Instead of targeting neurons directly, the therapy restores the proper function of the blood-brain barrier (BBB), the vascular gatekeeper that regulates the brain’s environment. By repairing this critical interface, the researchers achieved a reversal of Alzheimer’s pathology in animal models.
Ultrathin structures that can bend, focus, or filter light, metasurfaces are reshaping how scientists think about optics. These engineered materials offer precise control over lights behavior, but many conventional designs are held back by inefficiencies. Typically, they rely on local resonances within individual nanostructures, which often leak energy or perform poorly at wide angles. These shortcomings limit their usefulness in areas like sensing, nonlinear optics, and quantum technologies.
A growing area of research looks instead to nonlocal metasurfaces, where interactions between many elements create collective optical effects. These collective behaviors can trap light more efficiently, producing sharper resonances and stronger interactions with matter. One of the most promising possibilities in this field is the development of photonic flatbands, where resonant behavior stays uniform across a wide range of viewing angles.
Another is creating chiral responses, which allow devices to distinguish between left-and right-handed circularly polarized light. Until now, however, achieving both flatband and chiral behavior with high efficiency on a single platform has remained a major challenge.