Lifeboat Foundation

A gene that plays a key role in regulating how bodies change across the 24-hour day also influences memory formation, allowing mice to consolidate memories better during the day than at night. Researchers at Penn State tested the memory of mice during the day and at night, then identified genes whose activity fluctuated in a memory-related region of the brain in parallel with memory performance.

Experiments showed that the gene, Period 1, which is known to be involved in the body’s circadian clock, is crucial for improved daytime memory performance. A paper describing the research was published online in the journal Neuropsychopharmacology.

The research demonstrates a link between the circadian system and memory formation and begins to piece together the molecular mechanisms that help form and keep memories. Understanding these mechanisms and the influence of time of day on memory formation could help researchers to determine how and when people learn best.

A synaptic-resolution map of the neural circuits of a Drosophila larval brain reveals its connection types, neuron types, and circuit motifs.

I think an AI girlfriend or boyfriend would mess up your social skills and emotions/mental health. The article mentions other issues as well. It could turn some into “incels” meaning feeling resentful towards real women and possibly violent, not just domestic violence in my opinion but I’m not an expert but I’ve read about that a bit.

Chatbots such as Eva AI are getting better at mimicking human interaction but some fear they feed into unhealthy beliefs around gender-based control and violence.

A single-cell genomics analysis of humans, chimpanzees and rhesus macaques reveals the molecular features that drive cellular and regulatory complexity of human brain evolution.

This is true. I’ve been missing photography and books. Too much YouTube even can give you a bit of depression and anxiety. I’m a YouTube addict I’ll admit.

Reducing social media usage by as little as 15 minutes per day can increase health and well-being, claims a new study published in the Journal of Technology in Behavioral Science. The findings indicate that a 15-minute reduction in social media usage has positive consequences for one’s social life, vitality, and health.

Research has shown that excessive social media use can lead to a range of negative outcomes, including increased feelings of loneliness, anxiety, and depression. Social media use has also been linked to poor sleep quality, decreased physical activity, and decreased face-to-face social interaction. These negative outcomes are particularly concerning given that young adults are among the heaviest social media users, with many spending several hours daily on social media platforms.

Continue reading “New study finds small reductions in social media use are linked to improvements in health and well-being” »

Autophagy biology has emerged as a ray of hope in addressing age-related diseases such as neurodegenerative disorders. Substantial effort in academia has been directed at advancing our understanding of the field and paving the way for ground-breaking therapies. But with genuine challenges in harnessing the power of autophagy and in developing effective therapies in this disease area, how close are we to really finding the first autophagy boosting drugs…?

The devastating impact of neurodegenerative diseases such as Parkinson’s, Alzheimer’s and amyotrophic lateral sclerosis (ALS), the most common form of Motor Neurone Disease (MND), cannot be overstated. According to the WHO, neurological diseases affect over a billion people globally and are the leading cause of disability and the second leading cause of death worldwide [1, 2]. Incidence is increasing too, predominantly driven by population growth and aging. And, with no prospect of a cure, people who develop these conditions face a bleak future.

Justifiably, this disease area has been the subject of intensive research for many years and there have been some breakthroughs along the way, possibly offering hope for the development of new therapies. However, translating scientific breakthroughs into viable drugs for patients has been enormously challenging.

Neurologists at a memory clinic in China diagnosed a 19-year-old with what they believe to be Alzheimer’s disease, making him the youngest person to be diagnosed with the condition in the world.

The male teenager began experiencing memory decline around age 17, and the cognitive losses only worsened over the years.

Continue reading “Scientists Diagnose The Youngest Case of Alzheimer’s Ever Reported” »

A protein fragment from the brain could be used to track progression of Alzheimer’s disease. The tell-tale fragment of tau protein was detectable in the cerebrospinal fluid (CSF) of patients with the disease, and researchers now hope to develop a blood test using it.

Alzheimer’s is a disease of errant protein aggregates that include amyloid plaques and then later tau tangles. ‘Amyloid plaques begin to form about 10 to 20 years before the first symptoms of Alzheimer’s,’ says Randall Bateman, a neurologist at Washington University School of Medicine who helped lead the study. ‘Whereas tau tangles begin once the symptoms begin.’

Studies in two patient groups, each with hundreds of people, revealed that levels of the fragment in the CSF were indicative of tau clumps in the brain seen on imaging and were linked to symptoms of cognitive decline.

Developments in connectomics and network neuroscience over the past 20 years have led to new ways of investigating communication in complex brain networks. In this Review, Seguin, Sporns and Zalesky discuss the current landscape of models of brain network communication.