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Category: neuroscience – Page 2

Body image issues in adolescence are linked to depression in adulthood, twin study finds

Teenagers who are unhappy with their bodies are more likely to develop symptoms of eating disorders and depression in early adulthood, according to a new study led by University College London (UCL) researchers.

The research, believed to be the first of its kind, followed more than 2,000 twins born in England and Wales. It found that higher body dissatisfaction at age 16 predicted greater symptoms of eating disorders and depression well into the twenties, even after taking into account family background and genetics.

Researchers say the findings strengthen evidence that a negative body image is not just a reflection of poor mental health, but that it can also contribute to it.

Stress hormones can alter brain networks and strengthen emotional memories

Stress influences what we learn and remember. The hormone cortisol, which is released during stressful situations, can make emotional memories in particular stronger. But how exactly does cortisol help the brain build emotional memories?

In a new study, Yale researchers investigated just that. Specifically, they wanted to know how cortisol acts separately on brain circuits that track emotion and those that track memory. They found that cortisol not only helped people remember emotional experiences but also enhanced emotional memory by changing the dynamic brain networks associated with both memory and emotion.

“We all experience stress, and my lab is interested in understanding how stress can be helpful,” said corresponding author Elizabeth Goldfarb, an assistant professor of psychiatry at Yale School of Medicine and of psychology in the Faculty of Arts and Sciences.

Breakthrough uses artificial intelligence to identify different brain cells in action

A decades-old challenge in neuroscience has been solved by harnessing artificial intelligence (AI) to identify the electrical signatures of different types of brain cells for the first time, as part of a study in mice led by researchers from UCL.

Quantum clues to consciousness: New research suggests the brain may harness the zero-point field

What if your conscious experiences were not just the chatter of neurons, but were connected to the hum of the universe? In a paper published in Frontiers in Human Neuroscience, I present new evidence indicating that conscious states may arise from the brain’s capacity to resonate with the quantum vacuum—the zero-point field that permeates all of space.

More specifically, I argue that macroscopic quantum effects are at play inside our heads. This insight results from a synthesis of brain architectural and neurophysiological findings supplemented with quantitative model calculations. The novel synthesis suggests that the brain’s basic functional building blocks, cortical microcolumns, couple directly to the zero-point field, igniting the complex dynamics characteristic of conscious processes.

Short-Term Head-Out Whole-Body Cold-Water Immersion Facilitates Positive Affect and Increases Interaction between Large-Scale Brain Networks

An emerging body of evidence indicates that short-term immersion in cold water facilitates positive affect and reduces negative affect. However, the neural mechanisms underlying these effects remain largely unknown. For the first time, we employed functional magnetic resonance imaging (fMRI) to identify topological clusters of networks coupled with behavioural changes in positive and negative affect after a 5 min cold-water immersion. Perceived changes in positive affect were associated with feeling more active, alert, attentive, proud, and inspired, whilst changes in negative affect reflected reductions in distress and nervousness.

Medications change our gut microbiome in predictable ways

The bacteria in our poop are a reasonable representation of what’s living in our digestive system. To understand how different drugs can impact the gut microbiome, the team cultured microbial communities from nine donor fecal samples and systematically tested them with 707 different clinically relevant drugs.

The researchers examined changes in the growth of different bacterial species, the community composition, and the metabolome – the mix of small molecules called metabolites that microbes produce and consume. They found that 141 drugs altered the microbiome of the samples and even short-term treatments created enduring changes, entirely wiping out some microbial species. The primary force behind how the community responds to drug inhibition was competition over nutrients.

“The winners and losers among our gut bacteria can often be predicted by understanding how sensitive they are to the medications and how they compete for food,” said the first author on the paper. “In other words, drugs don’t just kill bacteria; they also reshuffle the ‘buffet’ in our gut, and that reshuffling shapes which bacteria win.”

Despite the complexity of the bacterial communities, the researchers were able to create data-driven computer models that accurately predicted how they would respond to a particular drug. They factored in the sensitivity of different bacterial species to that drug and the competitive landscape – essentially, who was competing with whom for which nutrients.

Their work provides a framework for predicting how a person’s microbial community might change with a given drug, and could help scientists find ways to prevent these changes or more easily restore a healthy gut microbiome in the future.

Our gut microbiome is made up of trillions of bacteria and other microbes living in our intestines. These help our bodies break down food, assist our immune system, send chemical signals to our brain, and potentially serve many other functions that researchers are still working to understand. When the microbiome is out of balance – with not enough helpful bacteria or the wrong combination of microbes – it can affect our whole body.

Continue reading “Medications change our gut microbiome in predictable ways” | >

Real-time imaging captures what happens to cancer cells arriving in the brain

Metastasis occurs when cancer cells break away from the original tumor and travel through the bloodstream to form new tumors in other parts of the body. It is the leading cause of cancer-related death. Brain metastasis is particularly severe and affects 10–30% of patients with advanced lung, breast, and melanoma cancers.

While therapies exist for established brain tumors, there are limited strategies that directly target the very first cancer “seed cells” that enter and lodge in the brain.

Our brains, however, are equipped with immune cells called microglia that rapidly respond to pathogens and cancer cells by engulfing and digesting them. Yet scientists could not explain why microglia sometimes fail to destroy incoming seed cells because they could not watch this critical interaction in real-time in the living brain.

Human Consciousness Comes From a Higher Dimension, Scientist Claims—Meaning It Could Transcend the Physical World

When we think creatively, produce novel ideas, or otherwise have “Eureka” moments, we may actually unlock access to a dimension outside of our everyday perception, according to the controversial theory.

Priming for depression in a dimly lit world

St. Hedwig Hospital and Charité–Universitätsmedizin Berlin researchers report that repeated mornings spent under dim indoor light in healthy young adults raised afternoon and evening cortisol and reshaped sleep in ways known from depressive illnesses.

Depressive disorders are often linked with hyperactivity of the hypothalamic–pituitary–adrenal axis, with cortisol levels that stay elevated into the afternoon and early evening instead of reaching their lowest levels, typical of early evening.

Sleep in depressive illness often carries its own fingerprint. Changes in REM sleep and a shift of slow wave sleep from the beginning of the night toward later phases have been described as biological markers of depression.

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