Most treatments for Parkinson’s disease (PD) only slow disease progression. Early intervention for the neurological disease that worsens over time is therefore critical to optimize care, but that requires early diagnosis. Current tests, like clinical rating scales and neural imaging, can be subjective and costly. Now, researchers in ACS’ Analytical Chemistry report the initial development of a system that inexpensively screens for PD from the odors in a person’s earwax.

Previous research has shown that changes in sebum, an oily substance secreted by the skin, could help identify people with PD. Specifically, sebum from people with PD may have a characteristic smell because volatile organic compounds (VOCs) released by sebum are altered by disease progression — including neurodegeneration, systemic inflammation and oxidative stress.

However, when sebum on the skin is exposed to environmental factors like air pollution and humidity, its composition can be altered, making it an unreliable testing medium. But the skin inside the ear canal is kept away from the elements. So, Hao Dong, Danhua Zhu and colleagues wanted to focus their PD screening efforts on earwax, which mostly consists of sebum and is easily sampled.

A groundbreaking study suggests that Parkinson’s disease may begin in the kidneys, where a toxic protein builds up and travels to the brain. This discovery could reshape our understanding of the disease’s origins and risk factors.

Every three seconds, someone in the world develops dementia. Alzheimer’s disease is the most common form of dementia, accounting for between 60% and 70% of all cases.

Although scientists have made significant progress in understanding the disease, there’s still no cure. That’s partly because Alzheimer’s disease has multiple causes—many of which are still not fully understood.

Two proteins which are widely believed to play central roles in Alzheimer’s disease are amyloid-beta and tau. Amyloid-beta forms sticky plaques on the outside of brain cells. This disrupts communication between neurons. Tau accumulates inside brain cells, where it twists into tangles. This ultimately leads to cell death. These plaques and tangles are the hallmark features of Alzheimer’s disease.