Lifeboat Foundation

A leading expert in socially responsible technology innovation Dr Andrew Maynard told us “I think Musk’s overreaching and he probably knows it.

”That said, Elon Musk has got a track record of doing things that other people said can’t be done. So I think that this is going to be an interesting space because of that… [But] I think we’re a long way from understanding how this works.

”Even with Elon Musk’s system you have around ten thousand electrodes. There are billions of neurons in your brain. It’s a needle in a haystack”.

Scientists hope the CRISPR-based therapy could treat neurodegenerative disease.

Scientists investigating Alzheimer’s treatments at the Salk Institute have uncovered some key mechanisms that enable an experimental drug to reverse memory loss in mouse models of the disease. The discovery not only bodes well for the possibility of clinical trials, but provides researchers with a new target to consider in the wider development of compounds to counter the degenerative effects of the condition.

The research centers on a drug called CMS121, which is a synthetic version of a chemical called fisetin that occurs naturally in fruits and vegetables. The Salk team’s previous studies concerning CMS121 have produced some very promising results, with one paper published last year describing how the drug influences age-related metabolic pathways in the brain, protecting against the type of degeneration associated with Alzheimer’s. This followed earlier studies demonstrating how fisetin can prevent memory loss in mice engineered to develop Alzheimer’s.

Work continues at Salk to understand how exactly fisetin and the synthetic variant CMS121 produces these anti-aging effects on the brain. In their latest study, the researchers again turned to mice engineered to develop Alzheimer’s, which were administered daily doses of CMS121 from the age of nine months. This is the equivalent to middle age in humans, with the mice already exhibiting learning and memory problems before the treatment began.

Newswise — Most of modern medicine has physical tests or objective techniques to define much of what ails us. Yet, there is currently no blood or genetic test, or impartial procedure that can definitively diagnose a mental illness, and certainly none to distinguish between different psychiatric disorders with similar symptoms. Experts at the University of Tokyo are combining machine learning with brain imaging tools to redefine the standard for diagnosing mental illnesses.

“Psychiatrists, including me, often talk about symptoms and behaviors with patients and their teachers, friends and parents. We only meet patients in the hospital or clinic, not out in their daily lives. We have to make medical conclusions using subjective, secondhand information,” explained Dr. Shinsuke Koike, M.D., Ph.D., an associate professor at the University of Tokyo and a senior author of the study recently published in Translational Psychiatry.

“Frankly, we need objective measures,” said Koike.

Continue reading “Future mental health care may include diagnosis via brain scan and computer algorithm” »

“How would you like to be known as the neurosurgeon who cured Parkinson’s disease?”

A month before the scheduled surgery, the four researchers were ready to chaperone the brain cells on their 190-mile journey. They never anticipated they were in for “The Amazing Race”-meets-“ER.”

It was after midnight on a late summer night in 2017, and they had less than eight hours to get the cells by ambulance, private plane, and another ambulance from Dana-Farber Cancer Institute in Boston to Weill Cornell Medical Center in Manhattan. If it took longer, the cells would almost certainly be DOA, and so might the researchers’ plan to carry out an experimental transplant surgery unprecedented in the annals of medicine: replacing the dysfunctional brain cells of a Parkinson’s disease patient with the progeny of an extraordinary type of stem cell. Created in the lab from a patch of the patient’s own skin, these cells, it was hoped, would settle into the brain like they belonged there and permanently restore the patient’s ability to walk and move normally.

Continue reading “Doctors treat Parkinson’s with a novel brain cell transplant” »

Network neuroscience could revolutionize how we understand the brain—and change our approach to neurological and psychiatric disorders.

Individual frequency can be used to specifically influence certain areas of the brain and thus the abilities processed in them — solely by electrical stimulation on the scalp, without any surgical intervention. Scientists at the Max Planck Institute for Human Cognitive and Brain Sciences have now demonstrated this for the first time.

Stroke, Parkinson’s disease and depression — these medical illnesses have one thing in common: they are caused by changes in brain functions. For a long time, research has therefore been conducted into ways of influencing individual brain functions without surgery in order to compensate for these conditions.

Scientists at the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig have taken a decisive step. They have succeeded in precisely influencing the functioning of a single area of the brain. For a few minutes, they inhibited exactly the area that processes the sense of touch by specifically intervening in its rhythm. As a result, the area that was less networked with other brain regions, its so-called functional connectivity, decreased, and thus also the exchange of information with other brain networks.

A Sound Treatment

Ultrasound is an oddball in the neuromodulation world. Similar to its better-known siblings, such as transcranial direct current stimulation (tDSC) or transcranial magnetic stimulation (TMS), ultrasound changes how neurons fire, which in turn changes their computational output—what we observe as learning, memory, and other behaviors. This idea, dubbed neuromodulation, has taken the neurological world by storm for its near “magical” efficacy for treating people with depression who don’t respond to antidepressants, or people with Parkinson’s disease whose movement patterns are severely disrupted.

Compared to first-generation neuromodulation, where the brain-tweaking gadget is surgically implanted into the brain, ultrasound offers a way to “hack” neural firings from the outside. In a way, the technology uses sound waves to mechanically “shake” the neurons in a circuit back into sequence, so they function in sync as needed and control subsequent outputs like learning, thinking, memory, and decision-making.

Continue reading “How Scientists Influenced Monkeys’ Decisions Using Ultrasound in Their Brains” »

Dopamine, dopamine, wherefore art thou my dopamine?

Oh wait, I just need to press a button on my computer for that!

The American Chemical Society (ACS) are closer to using electronics in the body, to diagnose tumours and track illnesses: Read about it on OAG.

Continue reading “One step closer to implanting electronics in the body” »