Lifeboat Foundation

Peripheral Elevation of a #Klotho Fragment Enhances Brain Function and Resilience in Young, Aging, and α-Synuclein Transgenic Mice.

Klotho is a longevity factor associated with cognitive enhancement when genetically and widely overexpressed over the lifetime of mice. Leon et al. show that peripheral delivery of a klotho fragment, αKL-F, acutely enhances cognition and neural resilience in young, aging, and disease model mice, establishing its therapeutic relevance and dissecting its underlying mechanisms.

Fun event if you’re in London on May 30th smile

___ Heads-up: the Imperial College Centre for Neurotechnology will host a keynote by Alvaro Fernandez on Wednesday, May 30th, titled Why the Future of Brain Enhancement & Mental Health is Digital & Pervasive. Description: As seen in patent and investment trends, research findings and consumer/patient behaviors, Mental.

The quantum race is on, and the stakes are high. The winner will gain a military and intelligence edge, as well as a first mover advantage in what is guaranteed to be a massive industry for decades to come. How will the United States fare?

Blog Post by Guest Blogger for Adam Segal.

A new open access paper takes a look at the potential of regenerative medicine for the treatment of Alzheimer’s disease [1]. The review covers approaches such as spurring the production of new neurons and transplanting new neurons while taking a look at the disease-modeling approaches and techniques that science is now using to refine approaches to treating Alzheimer’s.

The authors here investigate how induced pluripotent stem cells (iPSCs) are contributing to the growing knowledge in the field by allowing researchers to create increasingly refined models of Alzheimer’s disease. A current problem we have is that animal models do not emulate the disease closely enough to lead to translational therapies that work in humans; this is why so many new medicines that work in mice fail in clinical trials. The review takes a look at the challenges and how science is working to develop better models.

Introduction

Continue reading “A Review of Stem Cell Therapies for Alzheimer’s Disease” »

A man in Paris has become the world’s first to successfully receive two facial transplants.

Jérôme Hamon, 43, underwent his first face transplantation procedure in 2010 to treat neurofibromatosis, a genetic disorder characterized by the growth of tumors along nerves in the skin, brain and other parts of the body. Yet Hamon’s body rejected the original transplant.

In January, a team of surgeons and paramedics at Georges Pompidou European Hospital AP-HP, led by surgeon Dr. Laurent Lantieri, performed Hamon’s second transplant.

Continue reading “Man’s second face transplant is a world first” »

But the mice didn’t seem any smarter than usual.

Important — “The researchers found that sedentary behavior is a significant predictor of thinning of the MTL and that physical activity, even at high levels, is insufficient to offset the harmful effects of sitting for extended periods”

— In the study, both (A) Total medial temporal lobe (MTL) and (B) parahippocampal thickness correlated inversely with hours of sitting/day, controlling for age. Reference: Siddarth P et al (2018), Sedentary behavior associated with reduced medial temporal lobe thickness in middle-aged and older adults. PLOS ONE.

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