Lifeboat Foundation

Useful video for the development of the rejuvenation industry.

Scientists today now have a better understanding of the aging process, giving us a better explanation of the cellular changes that lead our body and brain to decline as we age.

Continue reading “Braeden Lichti: Investing in Anti-Aging and Rejuvenation Biotechnology” »

Exercise boosts your brain, but a walk on the wild side is what you need to keep your hippocampus happy.

Over many years, the Mazmanian laboratory has described how Bacteroides fragilis in the gut produces beneficial molecules that protect mice from inflammatory bowel disease and autism-like symptoms. Like a densely populated city, a vast majority of the B. fragilis in the gut live within the central part of the intestinal tube, called the lumen. However, the Mazmanian laboratory discovered in 2013 that some B. fragilis reside in the bacterial equivalent of small towns, nestled into microscopic pockets within the tissue walls lining the tube. These sparse populations are protected by mucus and are largely unaffected by antibiotics, suggesting that they act as population reservoirs that ensure long-term colonization.

“For humans, where we live can dictate how we behave—for example, a person living in a city likely has a different everyday life than a person living in a small rural community,” says former graduate student Gregory Donaldson (PhD ‘18), the first author on the new paper. “For the bacteria that we study, the intestines represent their entire world, so we wanted to know how differently they behave depending on how far away from the intestinal surface they are.”

Though they may live in different habitats within the gut, these B. fragilis populations all have the same genetic code. What may differ, however, is how they express those genes—is a bacterium expressing a gene for replication and division, for example, or perhaps for an enzyme that digests food? Donaldson aimed to measure and compare gene expression in these two populations (intestinal wall tissue and lumen of the gut) to determine what, if any, differences were seen.

Continue reading “Mapping Bacterial Neighborhoods in the Gut” »

Scientists examine the “engine for consciousness.”

A new study shows that the effects of aging appear in the brain can appear in your 40s. Cutting carbohydrates may protect you, though.

In order to understand what another person thinks and how he or she will behave, people must adopt someone else’s perspective. This ability is referred to as “theory of mind.” Until recently, researchers were at odds concerning the age at which children are able to do such perspective-taking. Scientists at the Max Planck Institute for Human Cognitive and Brain Sciences (MPI CBS), University College London, and the Social Neuroscience Lab Berlin shed new light on this question in a study now published in the Proceedings of the National Academy of Sciences.

According to the study, four-year-olds seem to be able to understand what others think. The study reports that this unique ability emerges around four years of age because of the maturation of a specific brain network that enables this. Younger children are capable of predicting others’ behavior based on what they think, but the study shows that this prediction of behavior relies on a different brain network. The brain seems to have two separate systems to take another person’s perspective, and these mature at different rates.

The researchers investigated these relations in a sample of three- to four-year-old children with the help of a video clips that show a cat chasing a mouse. The cat watches the mouse hiding in one of two boxes. While the cat is away, the mouse sneaks over to the other box, unnoticed by the cat. Thus, when the cat returns, it should still believe that the mouse is in the first location.

This month, an international team put all of those ingredients together, turning theory into reality.

The three labs, scattered across Padova, Italy, Zurich, Switzerland, and Southampton, England, collaborated to create a fully self-controlled, hybrid artificial-biological neural network that communicated using biological principles, but over the internet.

The three-neuron network, linked through artificial synapses that emulate the real thing, was able to reproduce a classic neuroscience experiment that’s considered the basis of learning and memory in the brain. In other words, artificial neuron and synapse “chips” have progressed to the point where they can actually use a biological neuron intermediary to form a circuit that, at least partially, behaves like the real thing.

Continue reading “Scientists Linked Artificial and Biological Neurons in a Network—and Amazingly, It Worked” »

We need to figure out the ethical implications before they arrive.

Scientists have found that an area of our brain, known as the Default Mode Network, is responsible for our ego and the subsequent psychological disorders that stem from it.