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Sam Harris and Roger Penrose | Consciousness, split brains, and the illusion of the Self

Sam Harris and Roger Penrose discuss the mysteries of consciousness and selfhood.

Is the Self merely an illusion?

With a free trial, you can watch the full debate NOW at https://iai.tv/video/the-divided-self-sam-harris-roger-penro…escription.

Many have sought to divide the self into separate parts. From Aristotle’s distinction between the rational and irrational self to Freud’s separation of the conscious and unconscious mind, from Kahneman’s fast and slow self to McGilchrist’s selves of the left and right brain. But critics argue it makes no sense to see the self as divided. From Descartes to Sartre, many philosophers have concluded that to be conscious is to be conscious of something and there can be no further self hiding within consciousness. After all, if there are two aspects of the self does it not require a third to oversee or combine them? Meanwhile, neuroscience has been unable to identify a self at all let alone multiple selves.

Should we give up the idea of distinct selves as simply incoherent? Should we conclude that a single self is necessary to account for conscious experience and to enable responsibility for action? Or are multiple selves a better way to explain the wildly divergent thoughts and contradictory behaviours that we can sometimes exhibit?

#consciousness #samharris #rogerpenrose.

Genetics, Not Maternal Sickness, Drives Autism Risk

Health during pregnancy does not cause autism, according to a study of 1.1M pregnancies. Genetics and fetal complications play a much larger role, challenging long-held assumptions about autism risk factors. +.


Summary: A large study analyzing over 1.1 million pregnancies found no strong evidence that maternal health conditions during pregnancy cause autism. Instead, nearly all previously reported associations between maternal diagnoses and autism could be explained by genetic or environmental factors.

Researchers found that only fetal complications remained statistically linked to autism, suggesting these issues might be early signs rather than causes. By analyzing sibling and paternal health records, the study further ruled out many maternal conditions as contributing factors.

The findings emphasize that autism likely begins before birth due to genetic influences rather than maternal health conditions. This research may help alleviate guilt for parents and shift focus toward early diagnosis and support.

Imaging Reveals Gut-Brain Connection in Alzheimer’s Disease

Summary: Scientists have used advanced X-ray phase-contrast tomography (XPCT) to uncover how gut health may influence Alzheimer’s disease. The study found structural changes in the gut of Alzheimer’s-affected mice, revealing abnormalities in intestinal cells, neurons, and mucus secretion.

This supports the hypothesis that harmful gut bacteria may escape into circulation, triggering brain inflammation and neurodegeneration. The findings highlight the gut-brain connection and provide a new tool for detecting early disease markers.

Researchers aim to further explore how the enteric nervous system communicates with the brain in Alzheimer’s. The study paves the way for potential new therapeutic targets based on gut health.

Harnessing chaos: How the brain turns randomness into robust memory

Random noise, such as background hubbub on a phone call, is usually thought of as unwanted interference. Now researchers at Columbia Engineering find the brain may harness unavoidable random fluctuations of its activity to perform useful computations, particularly in tasks relying on memory.

These findings not only deepen our understanding of how the brain works, but also may provide a blueprint for building smarter, more resilient technologies, the research team says.

They detailed their findings Jan. 16 in the Proceedings of the National Academy of Sciences.

The Brain Emulation Challenge Workshop Part 1 Teaser

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A Two-Part Series of Workshops.
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Join us as we lay the foundation for a rigorous, standardized, and open approach to brain emulation and related goals.

Eventbrite Page.

We don’t understand matter any better than mind

It is commonly believed that there is a mind-body problem because we can give an explanation of matter but not of the mind. But according to John Collins, we don’t understand matter either. Materialism was refuted by Newton in the 17th century, and the physicalism which has replaced it is not a substantive doctrine. There are gaps in our understanding of the mental – we still do not have a good theory of what the mind is – but after Newton, there is no ‘mind-body problem’

Minds are problematic. We don’t quite know what they are. If one has a mind, let us agree, then one is sentient and sapient, able to be self-aware and to think and reason about things. But both of these qualities are opaque, not least because they have no apparent analogy in the non-mental world. What, exactly, does one need to add to a body to get a mind? How is a thing that is merely subject to physical laws self-aware and able to think about dinosaurs and the afterlife? This conundrum is invariably depicted in terms of there being a mind-body problem. I’ll try in what follows to give you reasons to think that this label is at best misleading. There are lots of mind problems and lots of body problems, but no mind-body problem, because there is no realm of bodies in some general sense from which minds are excluded. Before you call for an intervention, let me explain.

A potted history.

Cognitive abilities: Mapping the impact of DNA modifications

A significant advancement in knowledge of the link between cognition and genetics has been made thanks to a study led by Université de Montréal graduate students Guillaume Huguet and Thomas Renne, working under the supervision of medical geneticist Sébastien Jacquemont, an associate professor of pediatrics and a researcher at the UdeM-affiliated CHU Saint-Justine.

Published in Cell Genomics, the research explored how the copy number variation, or CNV, of certain DNA segments can influence cognitive abilities.

Analyzing the CNV of nearly 260,000 people in the general population, the scientists were able to compare each individual’s CNV and cognition to define a reference model—a kind of “map” of the effects of CNV on cognition, such as the intelligence quotient and memory—and to establish links between these CNVs and achievements within the brain, as well as in other organs and tissues.

Overlapping copy number variations underlie autism and schizophrenia in Japanese patients

Common genetic variants may underlie autism spectrum disorder and schizophrenia across human populations, according to a study appearing September 11th in the journal Cell Reports. In line with previous studies in Caucasians, the researchers found that Japanese individuals with autism spectrum disorder and schizophrenia have overlapping copy number variations (CNVs)—inter-individual variations in the number of copies of a particular gene.

“The strength of our study is the systematic head-to-head comparison of pathogenic CNVs and biological pathways between and ,” says senior study author Norio Ozaki of Nagoya University Graduate School of Medicine. “Previous studies in Caucasian populations found overlap in pathogenic CNVs between the two disorders, but their analyses were limited to a small number of genes and CNV loci.”

Autism spectrum disorder and schizophrenia have complex inheritance patterns, with multiple genetic and environmental factors influencing disease risk. Available evidence points to genetic overlap between the two clinically distinct disorders. For example, they tend to co-occur at a higher rate than would be expected in the general population, and a large epidemiological study showed that a family history of schizophrenia in first-degree relatives is a risk factor for spectrum disorder. In particular, previous studies have revealed that these two disorders are associated with an increased burden of CNVs, and that rare CNVs in specific loci are shared risk factors for both disorders.

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