Lifeboat Foundation

Quanta Magazine’s coverage of biology in 2023, including important research progress into the nature of consciousness, the origins of our microbiomes and the timekeeping mechanisms that govern our lives and development.\
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Read about more breakthroughs from 2023 at Quanta Magazine: https://www.quantamagazine.org/the-bi…\
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00:05 The Investigation of Consciousness\
Our minds are constantly taking in new external information while also creating their own internal imagery and narratives. How do we distinguish reality from fantasy? This year, researchers discovered that the brain has a “reality threshold” against which it constantly evaluates processed signals. \
- Original story with links to research papers can be found here: https://www.quantamagazine.org/is-it–…\
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04:30 Microbiomes Evolve With Us\
This year, scientists provided clear evidence that the organisms in our microbiome —the collection of bacteria and other cells that live in our guts and elsewhere on our body — spread between people, especially those with whom we spend the most time. This raises the intriguing possibility that some illnesses that aren’t usually considered communicable might be.\
– Original story with links to research papers can be found here: https://www.quantamagazine.org/global…\
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08:43 How Life Keeps Time\
The rate at which an embryo develops and the timing of when its tissues mature vary dramatically between species. What controls the ticking of this developmental clock that determines an animal’s final form? This year, a series of careful experiments suggest that mitochondria may very well serve dual roles as both the timekeeper and power source for complex cells.\
- Original story with links to research papers can be found here: https://www.quantamagazine.org/what-m…\
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Quanta Magazine is an editorially independent publication supported by the Simons Foundation: https://www.simonsfoundation.org/

Synchron’s electrodes are delivered via blood vessel.

Until now, only about 50 humans have ever had BCIs implanted in their brains.

The CHOOSE system, an innovative approach combining brain organoids and genetics, transforms autism research by allowing detailed analysis of mutations and their effects on brain development.

Does the human brain have an Achilles heel that ultimately leads to Autism? With a revolutionizing novel system that combines brain organoid technology and intricate genetics, researchers can now comprehensively test the effect of multiple mutations in parallel and at a single-cell level within human brain organoids.

This technology, developed by researchers from the Knoblich group at the Institute of Molecular Biotechnology (IMBA) of the Austrian Academy of Sciences and the Treutlein group at ETH Zurich, permits the identification of vulnerable cell types and gene regulatory networks that underlie autism spectrum disorders. This innovative method offers unparalleled insight into one of the most complex disorders that challenge the human brain with implications that bring autism clinical research much-needed hope.

This Review examines the development of neuromorphic hardware systems based on halide perovskites, considering how devices based on these materials can serve as synapses and neurons, and can be used in neuromorphic computing networks.

For those of you for whom the grind never stops, the tech startup Prophetic is offering an unusual device that supposedly lets you work while you sleep — because when else are you supposed to get your side hustle in?

Called “Halo,” it’s a thick headband that Prophetic says is able to induce lucid dreams, the kind of dreams in which you’re aware that you’re dreaming and thus potentially able to take control of.

They can make for memorable if not life-changing experiences for some. But rather than wasting your time and dream power exploring your subconscious mind, Prophetic wants you to take lucid dreams by the reins and try being productive with them for a change.

The data collected by this research team confirms that mind-wandering is associated with an increase in alpha oscillations, which was also reported in previous works.

When humans are completing a specific task, their minds can shift from what they are doing to their own internal thoughts. This shift of attention from a task to internal events, known as off-task thinking or mind-wandering, is well-documented and has been studied extensively in the past.

A research question that remains unanswered is whether mind-wandering should be considered an adaptive/beneficial or maladaptive/undesirable process. Depending on the circumstances in which it occurs, in fact, this process could distract a person from an important task they are trying to complete or shift their attention onto something equally or more important for them.

Continue reading “Study suggests that the neural correlates of mind-wandering can vary across different tasks” »

Genetic screens have revealed three peripheral tissue genes that regulate sleep. What does this mean for sleep research?

Cortical gradient mapping stands as an innovative analytical tool for exploring the brain’s functional-spatial organization along a continuous spectrum^28,29,30, distinguishing it from conventional techniques reliant on discrete boundaries, e.g., functional parcellation in neuroimaging. As an intuitive metaphor, consider defining a geographic region by its boundary coordinates, which is akin to functional parcellation, versus describing it by elevation slopes or changes in vegetation types across various topographical axes, which is similar to gradient mapping. These cortical gradients span a wide spectrum of functions and networks, ranging from perception and action to higher-order cognitive processes²⁸. Notably, Gradient-1, known as the unimodal to transmodal gradient, enables the integration of sensory signals with non-sensory data, transforming them into abstract content. Gradient-2, the visual to somatomotor gradient, represents the specialization of different sensory modalities. Lastly, Gradient-3 spans functional distinctions ranging from regions typically deactivated during task performance (i.e., task-negative) to those activated in frontoparietal and attention networks (i.e., task-positive)^31,32. Despite promising foundations, the potential of gradients as a framework for analyzing and conceptualizing non-ordinary states of consciousness induced by psychedelics remains ripe for exploration.

In addition to the brain’s functional geometry, dynamic processes continuously mold and reconfigure functional arrangements, leading to the evolution of brain activity patterns over time^33,34. Recent empirical investigations have highlighted the intricate interplay between the spatial and temporal characteristics of brain activity, emphasizing that a comprehensive understanding necessitates the consideration of both aspects. Notably, transient fMRI co-activations^33,35,36 spanning the entire cortex have been observed to propagate like waves, following the spatially defined cortical gradients^37,38,39. Consequently, temporal dynamics are likely to be influenced by the underlying functional geometry. Exploring the co-variation between these spatial and temporal factors holds the potential to offer deeper insights into the neural underpinnings of psychedelic effects.

The objective of this study was to apply advanced cortical gradient mapping and co-activation pattern analysis to dissect the brain’s spatiotemporal reconfiguration during the psychedelic experience induced by nitrous oxide. Building upon previous research findings^16,25, we tested the hypothesis that nitrous oxide could diminish functional differentiation within the human cortex, as evidenced by a contraction in functional geometry and a disruption in temporal dynamics. We reanalyzed a neuroimaging dataset of healthy human volunteers, who were assessed by fMRI before and during exposure to psychedelic concentrations of nitrous oxide (35%, in oxygen) and who completed a validated altered states of consciousness questionnaire⁴⁰ before and after drug exposure. We quantified the changes of neural activity in cortical gradients and co-activations; we also performed correlation analyses to explore the relationship between subjective psychedelic experience and these brain measures. We demonstrate that nitrous oxide flattens the functional geometry of the cortex and disrupts related temporal dynamics, particularly within the frontoparietal and somatomotor networks, in association with the psychedelic experience.

Loihi 2 packs 1 million neurons in a chip half the size of its predecessor.