Toggle light / dark theme

Your gut microbes can be anti-aging—scientists are uncovering how to keep your microbiome youthful

People have long given up on the search for the Fountain of Youth, a mythical spring that could reverse aging. But for some scientists, the hunt has not ended—it’s just moved to a different place. These modern-day Ponce de Leóns are investigating whether gut microbes hold the secret to aging well.

The gut microbiome refers to the vast collection of microscopic organisms—bacteria, fungi, and viruses—that largely inhabit the colon. These microbes aid in digestion and produce molecules that affect your physiology and psychology. The composition of the microbiome is influenced by a combination of factors, including genetics, diet, the environment, medications, and age.

I’m a microbiology professor and author of “Pleased to Meet Me: Genes, Germs and the Curious Forces That Make Us Who We Are,” which describes how the gut microbiome contributes to physical and mental health. The discovery that the gut microbiome changes with age has ignited studies to determine whether the Fountain of Youth might be right under your nose, down inside your gut.

PV inhibitory neurons, not overall prefrontal cortex decline, linked to cocaine-seeking relapse

Drug addiction carries an extremely high risk of relapse, as cravings can be reignited by minor stimuli even long after one has stopped using. Previously, this phenomenon was attributed to a decline in the function of the prefrontal cortex (PFC), which regulates impulses. However, a joint international research team has recently revealed that the cause of addiction relapse is not a simple decline in brain function, but rather an imbalance in specific neural circuits.

Why anger feels close to fear: Brain charts emotion in a map-like way

It is well established in psychology that humans conceptualize emotions by features known as valence (the degree of pleasantness or unpleasantness) and arousal (the intensity of bodily reactions, such as rapid breathing or a racing heart).

If you think of “pleasantness” as longitude and “bodily reaction” as latitude, you can imagine a “mental map,” with nodes that “chart” knowledge of emotion.

The neural mechanisms giving rise to this configuration, however, have remained unclear.

Focused ultrasound subtly primes human brain to respond, EEG study finds

A research team at Carnegie Mellon University has developed a new noninvasive brain stimulation technique, by showing how focused ultrasound affects the human brain. Using brainwave recordings from human participants, the team found that focused ultrasound can subtly influence brain activity without directly causing neurons to fire. The work clarifies conflicting results in the field and introduces a new approach to noninvasive brain stimulation. The study is published in Nature Communications.

Focused ultrasound has been studied for years, but its effects in humans are not well understood. One challenge is that the technology makes a quiet beeping sound that can trigger hearing pathways in the brain, making it hard to know whether changes are caused by the sound or by the ultrasound itself. Previous studies using MRI scans may also produce misleading signals.

To address these limitations, researchers conducted a resting-state study in 27 human participants using concurrent whole-brain EEG recordings. They compared low-intensity transcranial focused ultrasound (tFUS) alone, a mild electrical brain stimulation called tDCS, and a new approach that combines the two, deemed transcranial electro-acoustic stimulation (tEAS). When used alone, neither ultrasound nor electrical stimulation caused clear, targeted brain responses. However, when combined, they produced strong, specific activity in the targeted area.

Patients with symmetric Parkinson’s disease do poorly with subthalamic stimulation

Patients with symmetric PD can be identified with a simple and straightforward method, a ratio right by left hemibody score equalling 1. This requires no additional time, effort or specialised neuroimaging or laboratory resources.


Background Motor asymmetry is a hallmark of Parkinson’s disease (PD), but ~20% of patients present with symmetric motor signs, which are associated with faster disease progression and poorer dopaminergic response. The impact of motor symmetry on activities of daily living (ADL) outcomes following subthalamic deep brain stimulation (STN-DBS) remains unclear. We hypothesised that patients with symmetric PD experience less ADL improvement post-STN-DBS than asymmetric PD patients.

Methods This was a prospective, quasi-experimental, non-randomised, controlled, international multicentre study with a 6-month follow-up. The primary outcome was the Scales for Outcomes in Parkinson’s Disease-Motor ADL scale. Secondary outcomes included Unified Parkinson’s Disease Rating Scale motor examination and Parkinson’s Disease Questionnaire-8 (PDQ-8). We defined symmetric PD as a right-to-left hemibody motor score equalling 1. We analysed within-group longitudinal changes, between-group outcome differences, effect size and correlations between PDQ-8 and motor changes. We confirmed results in a propensity-score matched subcohort with well-balanced demographic and clinical parameters.

Results We included 200 patients with asymmetric and 54 with symmetric PD. In symmetric PD, ADL remained stable, which was not associated with the observed PDQ-8 improvement. In contrast, in asymmetric PD, ADL improved with a moderate effect size, which correlated moderately with PDQ-8 improvement. In symmetric PD, the absolute risk of experiencing no clinically relevant postoperative ADL improvement was 23.8% higher.

Spontaneous metacognitive experiences and involuntary memories in the laboratory

A recent study published in Consciousness and Cognition provides evidence that everyday mental quirks like déjà vu or tip of the tongue states are natural byproducts of a resting mind. The findings suggest that when a person’s attention is not fully occupied, a wide variety of spontaneous thoughts and reflective feelings naturally emerge into awareness.

The scientists conducted the research to understand if a broad spectrum of unprompted mental experiences could be systematically captured in a laboratory setting. Past research has mostly focused on involuntary memories, which are recollections of personal events that pop into the mind without warning. The team wanted to know if the same boring, repetitive conditions that produce these memories might also generate other spontaneous phenomena.

They specifically focused on metacognition. Metacognition is a term used to describe the brain’s ability to think about and monitor its own processes. While people sometimes use metacognition deliberately, such as trying to gauge how well they learned a topic for a test, it can also happen without effort.

Spontaneous metacognition includes sudden feelings like déjà vu, which is the sensation that a new situation is highly familiar. It also includes the sudden realization that a well known word looks strangely incorrect, a phenomenon known as jamais vu.

“This study was motivated by the observation that many mental experiences—such as déjà vu, tip-of-the-tongue states, or sudden memories—seem to appear spontaneously in everyday life, yet they are usually studied separately in different areas of psychology,” explained study author Krystian Barzykowski, the head of the Applied Memory Research Laboratory at Jagiellonian University and Marie Skłodowska-Curie Postdoctoral Fellow at the Grenoble Alpes University.

Abstract: Consciousness and Cognition.

Everyday mental quirks like déjà vu might be natural byproducts of a resting mind

A recent study published in Consciousness and Cognition provides evidence that everyday mental quirks like déjà vu or tip of the tongue states are natural byproducts of a resting mind. The findings suggest that when a person’s attention is not fully occupied, a wide variety of spontaneous thoughts and reflective feelings naturally emerge into awareness.

The scientists conducted the research to understand if a broad spectrum of unprompted mental experiences could be systematically captured in a laboratory setting. Past research has mostly focused on involuntary memories, which are recollections of personal events that pop into the mind without warning. The team wanted to know if the same boring, repetitive conditions that produce these memories might also generate other spontaneous phenomena.

They specifically focused on metacognition. Metacognition is a term used to describe the brain’s ability to think about and monitor its own processes. While people sometimes use metacognition deliberately, such as trying to gauge how well they learned a topic for a test, it can also happen without effort.

Do we really control our own decisions?

For decades, neuroscientists have explored a fascinating phenomenon in the human brain known as the split-brain experiment. When the connection between the two hemispheres of the brain — the Corpus Callosum — is surgically cut, something extraordinary happens.

Each hemisphere begins processing information independently.

In groundbreaking research conducted by neuroscientist Michael Gazzaniga, scientists discovered that the speaking side of the brain often creates explanations for actions it did not initiate. This phenomenon is known as the Left-Brain Interpreter.

Instead of admitting uncertainty, the brain rapidly constructs logical stories to explain behavior. These experiments revealed how the human mind continuously builds a coherent narrative about our identity, decisions, and sense of self.

The split-brain studies remain one of the most important discoveries in modern neuroscience, raising profound questions about consciousness, decision-making, and the nature of the human mind.

Read more

/* */