The study, which is set to begin in the third quarter of 2025, will be a randomized, double-blind, placebo-controlled trial involving 40 stroke patients in Europe.
Dr. Nardai, a leading cerebrovascular disease specialist, is currently the Head of the Department of Neurointervention at Semmelweis University in Budapest, Hungary. He previously led a preclinical study published in Experimental Neurology in May 2020, which demonstrated that rats treated with sub-hallucinogenic doses of DMT showed near-complete motor function recovery and smaller infarct volumes compared to untreated control groups. This research provided the basis for Algernon’s clinical investigation into DMT as a potential neuroprotective agent for stroke recovery.
“The primary endpoint of the planned Phase 2a study will be safety,” said Dr. Nardai in the news release. “However, stroke clinicians worldwide will also be watching for positive signals regarding lesion volume, biomarkers, motor function, cognitive function, depression, and mortality.””
Algernon Pharmaceuticals Inc. (AGN: CSE; AGNPF: OTCQB; AGW0:XFRA) subsidiary Algernon NeuroScience has appointed Dr. Sandor Nardai as Principal Investigator for its upcoming Phase 2a DMT stroke study. Find out how this trial could reshape stroke recovery research.
Discover how MitoQ reverses vascular aging by 15–20 years! Chief Scientific Officer Dr. Mitchell reveals research on mitochondrial health, showing 42% improvement in blood flow and superior results vs CoQ10 for longevity. Some links are affiliate links so we will earn a commission when they are used to purchase products.
If you would like to support our channel please consider joining our Patreon / modernhealthspan. MitoQ https://tinyurl.com/5n93fm3f MitoQ Pure https://tinyurl.com/3hxy9s7x. Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US) AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw. All Muse devices 15% discount code MODERN https://choosemuse.com/MODERN Renue By Science 10% discount code MHS: https://tinyurl.com/bdew4bfs. NMN Powder https://tinyurl.com/syc7rwkh. DoNotAge 10% discount code MHS https://tinyurl.com/6dbvhv87 D3/K2 https://tinyurl.com/528z26b7 NMN https://tinyurl.com/wyzj2f3d. n1o1 Nitric Oxide 10% discount with code Modern https://tidd.ly/3IczGRW 15% off with code PRIME15 until July 12 n1o1 Nitric Oxide Lozenges https://tidd.ly/4eaJTdw. Age-Defiance Face Cream https://tidd.ly/4eaJTdw. Wellness Extract 10% discount Code MODERNWE Geranylgeraniol Essential http://wellnessextract.com/RICHARDWE Delta Gold Vit E Oxford Healthspan Spermidine 15% Code MHS Original https://tinyurl.com/hrxfnzpn, Gluten Free https://tinyurl.com/2s39pkzv. Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN Pendulum 20% Discount Code HEALTHSPAN Akkermansia https://pendulumtherapeutics.sjv.io/b… Daily https://pendulumtherapeutics.sjv.io/N… OmegaQuant 5% discount Code MODERN https://omegaquant.com/shop/ OneSkin 15% Discount: Code MODERN OS-01 Face https://oneskin.pxf.io/Z6Yg0K In this comprehensive interview, Dr. Mitchell, Chief Scientific Officer at MitoQ, breaks down the revolutionary science behind mitochondrial-targeted antioxidants and their impact on aging and disease prevention. *Key Topics Covered:* • How MitoQ delivers 90% bioavailability to mitochondria vs 10% for regular CoQ10 • Clinical study showing 42% improvement in flow-mediated dilation (vascular function) • Why mitochondrial dysfunction is the root cause of aging diseases • Exercise performance benefits: improved VO2 max, peak power, and recovery • Brain health and cognitive function improvements • Cardiovascular benefits: reduced oxidized LDL, improved artery flexibility • Immune system support and inflammation reduction • Diabetes prevention through improved glucose metabolism • Proper dosing protocols and supplement combinations *Research Highlights:* ✓ 25+ clinical studies and 800+ research papers ✓ Reverses vascular aging by 15–20 years according to leading researcher Doug Seals ✓ Professional cyclists and elite athletes using MitoQ for performance ✓ Ongoing trials for frailty, cognitive function, and neurovascular health ✓ 300+ independent researchers studying MitoQ applications Learn why targeting mitochondria may be the key to preventing age-related diseases and optimizing healthspan. Discover the science-backed approach to cellular energy and antioxidant protection that’s changing how we think about aging. ⏲️Chapters 0:00 The problem with mitochondria 3:34 How Mitochondria Dysfunction Occurs with Aging 5:43 Natural Protective Mechanisms and CoQ10 7:38 The Invention of MitoQ — Superior Mitochondrial Targeting 11:15 How MitoQ Differs from CoQ10 13:31 MitoQ vs CoQ10 — Research Comparisons 17:52 Cardiovascular Benefits and Flow-Mediated Dilation 23:32 Heart Muscle Function and Immune System Effects 28:16 Exercise Performance and V2 Max Improvements 32:04 Research Funding and Collaborative Programs 36:11 Diabetes Prevention and Glucose Metabolism 39:02 Brain Health and Cognitive Benefits 44:23 Dosing Protocol and Administration Guidelines 48:04 Supplement Combinations and Future Directions 🌐Links in this video MitoQ Home page https://www.mitoq.com/ Mitochondrial Collaborative Research Program https://www.mcrp.dev/ *************************************** Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. Please consult with your doctor first. Products or services mentioned in this video are not a recommendation. Audio Copyright Disclaimer Please note that we have full authorization to the music that we used in our videos as they were created using the service WeVideo which provides the rights to the music. The rights are detailed in the terms of use that can be reviewed here https://www.wevideo.com/terms-of-use and any following inquiries should be addressed to [email protected]. ************************************************ #MitoQ #Mitochondria #Longevity. Metabolic Daily https://pendulumtherapeutics.sjv.io/N… OmegaQuant 5% discount Code MODERN https://omegaquant.com/shop/ OneSkin 15% Discount: Code MODERN OS-01 Face https://oneskin.pxf.io/Z6Yg0K
In this comprehensive interview, Dr. Mitchell, Chief Scientific Officer at MitoQ, breaks down the revolutionary science behind mitochondrial-targeted antioxidants and their impact on aging and disease prevention.
*Key Topics Covered:* • How MitoQ delivers 90% bioavailability to mitochondria vs 10% for regular CoQ10 • Clinical study showing 42% improvement in flow-mediated dilation (vascular function) • Why mitochondrial dysfunction is the root cause of aging diseases. • Exercise performance benefits: improved VO2 max, peak power, and recovery. • Brain health and cognitive function improvements. • Cardiovascular benefits: reduced oxidized LDL, improved artery flexibility. • Immune system support and inflammation reduction. • Diabetes prevention through improved glucose metabolism. • Proper dosing protocols and supplement combinations.
*Research Highlights:* ✓ 25+ clinical studies and 800+ research papers. ✓ Reverses vascular aging by 15–20 years according to leading researcher Doug Seals. ✓ Professional cyclists and elite athletes using MitoQ for performance. ✓ Ongoing trials for frailty, cognitive function, and neurovascular health. ✓ 300+ independent researchers studying MitoQ applications.
Learn why targeting mitochondria may be the key to preventing age-related diseases and optimizing healthspan. Discover the science-backed approach to cellular energy and antioxidant protection that’s changing how we think about aging.
Researchers at Princeton University and the Simons Foundation have identified four clinically and biologically distinct subtypes of autism, marking a transformative step in understanding the condition’s genetic underpinnings and potential for personalized care.
Analyzing data from over 5,000 children in SPARK, an autism cohort study, the researchers used a computational model to group individuals based on their combinations of traits.
The team used a “person-centered” approach that considered a broad range of over 230 traits in each individual, from social interactions to repetitive behaviors to developmental milestones, rather than searching for genetic links to single traits.
Clinical studies suggest the therapeutic potential of psychedelics, including ayahuasca, DMT, psilocybin, and LSD, in stress-related disorders. These substan…
If you regularly experience headaches, dizziness, balance problems and blurred vision, our Neanderthal cousins could be to blame.
These are common symptoms of Chiari malformations, structural defects in which the lower part of the brain extends into the spinal cord. People with this condition have skulls shaped like those of our ancient relatives, leading to a hypothesis (known as the Archaic Homo Introgression Hypothesis) that it may be a genetic legacy from interbreeding between modern humans and Neanderthals.
To investigate this, Kimberly Plomp of the University of the Philippines Diliman and colleagues zeroed in on Chiari 1, the mildest form of the condition, which affects around 1 in 100 people.
The human brain is made up of billions of nerve cells (neurons) that communicate with each other in vast, interconnected networks. For the brain to function reliably, there must be a fine balance between two types of signals: Excitatory neurons that pass on information and increase activity, and inhibitory neurons that limit activity and prevent other neurons from becoming too active or firing out of control. This balance between excitation and inhibition is essential for a healthy, stable brain.
Inhibitory neurons are generated during brain development through the division of progenitor cells—immature cells not yet specialized but already on the path to becoming neurons. A new study, led by researchers at the Max Planck Institute for Biological Intelligence, has uncovered a surprising feature of brain development based on findings in mice: During this essential process, cells born later in development mature much more quickly than those produced earlier.
The findings are published in the journal Nature Neuroscience.
A compound found in psychedelic mushrooms may have antiaging properties. Researchers at Baylor College of Medicine have found that psilocybin, the active compound in psychedelic mushrooms, may extend both cellular and organismal lifespans.
The findings, published in the journal npj Aging, show that psilocybin reduced multiple hallmarks of aging in cells while also improving survival in aged mice.
“There have been a number of clinical studies that have explored the therapeutic potential of psilocybin in psychiatric conditions such as depression and anxiety; however, few studies have evaluated its impacts outside the brain,” said Dr. Louise Hecker, associate professor of medicine— cardiovascular research at Baylor and senior author of the study.
A new large-scale study spotlights postoperative delirium as a preventable and high-impact complication which is driven by patient frailty and surgical stress—and one that can be addressed through low-cost, evidence-based interventions.
The findings, which appear in JAMA Network Open, provide a call to action for clinicians, health systems, patients, and families to prioritize brain health throughout perioperative care.
“Postoperative delirium isn’t a minor complication—it’s analogous to acute brain failure, a medical emergency that should be recognized and addressed,” said Laurent Glance, MD, a professor of Anesthesiology and Perioperative Medicine at the University of Rochester Medical Center (URMC) and senior author of the study.
