Lifeboat Foundation

The brain is a marvel of efficiency, honed by thousands of years of evolution so it can adapt and thrive in a rapidly changing world. Yet, despite decades of research, the mystery of how the brain achieves this has remained elusive.

Our new research, published in the journal Cell, reveals how neurons – the cells responsible for your childhood memories, thoughts and emotions – coordinate their activity.

Continue reading “The Mystery of How Neurons Control The Brain Has Finally Been Solved” »

Scientists at the Centre for Genomic Regulation (CRG) in Barcelona have developed the first comprehensive blueprint of the human spliceosome, the most complex and intricate molecular machine found in every cell. This groundbreaking achievement, over a decade in the making, was published in the journal Science.

The spliceosome edits genetic messages transcribed from DNA, allowing cells to create different versions of a protein from a single gene. The vast majority of human genes – more than nine in ten – are edited by the spliceosome. Errors in the process are linked to a wide spectrum of diseases including most types of cancer, neurodegenerative conditions, and genetic disorders.

The sheer number of components involved and the intricacy of its function has meant the spliceosome has remained elusive and uncharted territory in human biology – until now.

Deep sleep could be key to forestalling slow declines in brain health that may one day lead to Alzheimer’s disease, the most common form of dementia.

In their 2023 study of 62 older, cognitively healthy adults, researchers from the University of California (UC) Berkeley, Stanford University, and UC Irvine in the US found individuals with brain changes associated with Alzheimer’s performed better on memory function tests as they got more deep sleep.

This was irrespective of education and physical activity, two factors along with social connection known to contribute to cognitive resilience in older age.

A multitude of genetic, behavioral, and environmental factors come together to create mental health problems in teens.

Using a broad genetic trawling method, scientists at Washington University identified connections between genetic risk factors and behaviors like screen time and stressful life events in youth. Their findings highlight potential areas for intervention to mitigate the risk of psychiatric disorders.

Genetic Research in Youth Behavior.

MIT researchers have uncovered two additional pathways in the brain’s striatum that modulate traditional movement control pathways by influencing dopamine production.

These pathways, connected to the brain’s striosomes, may play a crucial role in decisions with strong emotional components, potentially altering our understanding of how motivation and movement are interconnected.

In the human brain, movement is coordinated by a region called the striatum, which sends signals to motor neurons. These signals travel along two main pathways: one initiates movement (“go”), and the other inhibits it (“no-go”).

This finding, published in Science, was demonstrated by researchers from the Max Planck Institute of Animal Behavior, the Cluster of Excellence Center for the Advanced Study of Collective Behavior at the University of Konstanz, Germany, Tel Aviv University, and the Hebrew University of Jerusalem, Israel.

Would you be able to instantly recognize your location and find your way home from any random point within a three-kilometer radius, in complete darkness, with only a flashlight to guide you?

Continue reading “Study shows bats have acoustic cognitive maps” »

Changes to actin dynamics during brain aging are not well understood. Here, the authors report that there is an age-related increase in F-actin in Drosophila brain which disables autophagy within the tissue and limits the fly lifespan.

White holes, the theoretical opposites of black holes, could expel matter instead of absorbing it. Unlike black holes, whose event horizon traps everything, white holes would prevent anything from entering. While no white holes have been observed, they remain an intriguing mathematical possibility. Some astrophysicists have speculated that gamma ray bursts could be linked to white holes, and even the Big Bang might be explained by a massive white hole. Although the second law of thermodynamics presents a challenge, studying these singularities could revolutionize our understanding of space-time and cosmic evolution.

After reading the article, Harry gained more than 724 upvotes with this comment: “It amazes me how Einstein’s theory and equations branched off into so many other theoretical phenomena. Legend legacy.”

Black holes may well be the most intriguing enigmas in the Universe. Believed to be the collapsed remnants of dead stars, these objects are renowned for one characteristic in particular – anything that goes in never comes out.

UC Davis researchers have identified new cell clusters in the amygdala that could hold keys to treating anxiety and depression.

Effective treatment for anxiety, depression, and other emotional disorders may rely on the amygdala—a part of the brain that regulates strong emotional responses, particularly fear. Until recently, understanding of this structure was limited. Now, researchers at the University of California, Davis, have identified distinct clusters of cells in the amygdala of humans and non-human primates, each with unique patterns of gene expression. This discovery could pave the way for more targeted treatments for conditions like anxiety, which impact tens of millions worldwide.

The findings were published on October 30 in the American Journal of Psychiatry.