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A multi-university research team co-led by University of Virginia engineering professor Gustavo K. Rohde has developed a system that can spot genetic markers of autism in brain images with 89 to 95% accuracy.

Their findings suggest doctors may one day see, classify and treat autism and related neurological conditions with this method, without having to rely on, or wait for, behavioral cues. And that means this truly personalized medicine could result in earlier interventions.

Continue reading “UVA Research Cracks the Autism Code, Making the Neurodivergent Brain Visible” »

Here’s the secret of how your brain retains information, and how it could unlock the potential for cognitive enhancement.

, while an interesting thought experiment, does not seem to account for the fact that many phenomena are materialistic or physical enough to have no resemblance with the qualities we typically attribute to consciousness, such as experience and motive.

Panprotopsychism, by contrast, does not require matter to be intrinsically conscious, only that it be comprised of features equaling consciousness when combined.

Continue reading “Panprotopsychism: Panpsychism” »

Throughout history, humans have sought to transcend the ordinary boundaries of consciousness, reaching for experiences beyond the everyday. They did this through various means, including the use of psychedelics and mind-altering substances. These substances have played a profound role in shaping ancient rituals, belief systems, and even governance. From the shamanic traditions of Siberia to the sophisticated ceremonies of the Maya, the use of psychoactive plants and compounds has been a ubiquitous feature of human culture. The influence of these substances extended far beyond mere spiritual exploration; they became intertwined with the very fabric of ancient societies, affecting political structures, social hierarchies, and religious practices. To fully understand their influence, we must study the intricate relationships between psychedelics, ritual practices, and governance in ancient civilizations, examining how these substances were used to achieve altered states of consciousness, connect with the divine, and wield power.

Visions From Beyond: The Role of Psychedelics in Ancient Rituals

Psychedelics have long been associated with religious and spiritual rituals, serving as gateways to the divine or as tools for gaining insight into the cosmos. In many ancient societies, these substances were not merely recreational but were integral to the religious experience, often seen as sacraments that enabled communication with gods or spirits.

Chinese scientists have developed a method using genetic engineering to potentially enhance brain-computer interface (BCI) technology by enlarging neurons for better signal transmission.

The researchers, with the Chinese Academy of Sciences’ National Centre for Nanoscience…

Gene sequence could be implanted with electrodes to make neurons larger and easier to ‘read’ in quest for better mind control of devices.

Continue reading “Chinese researchers’ implant genetically modifies brain cells for neuron growth” »

Aging is known to have profound effects on the human brain, prompting changes in the composition of cells and the expression of genes, while also altering aspects of the interaction between genes and environmental factors. While past neuroscience studies have pinpointed many of the molecular changes associated with aging, the age-related genetic factors influencing specific neuron populations remains poorly understood.

Recent studies on flies, mice, primates and human brain tissue utilizing single-cell or single-nucleus RNA-sequencing and genetic experimental techniques shed new light on these cell-type-specific changes. For instance, they unveiled the effects of aging on glial cells in the mouse and human brain, associations between cell-specific changes and modified chromatin proteins, and the influence of DNA methylation in the aging of various tissues.

Researchers at University of California (UC) San Diego and Salk Institute recently carried out a study aimed at better understanding how both age and sex impact human cortical neurons at a single-cell level. Their findings, published in Neuron, offer new insights into how aging affects cell composition, gene expression and DNA methylation across human brain cell types, while also uncovering differences between gene expression and DNA methylation in females and males.

You can demonstrate a subjective quality like redness is different from red light. If you add a device that converts a red signal into a green one, between the retina and the optic nerve, the strawberry will seem green. It’s not about light hitting the retina, it’s about how the signal is processed. In this case, the greenness must be a quality of our conscious knowledge of the strawberry, not of the red light landing on the retina. If you use sufficient, well defined terminology, you can objectively communicate the nature of subjective qualities. For example, even though you know what it is like to see something that is red you cannot know that what happens inside my brain is the same as yours. It may be that “My redness is like your greenness, both of which we call red.” The properties of the red light are the same, but the experience the light produces could be different.

When sensory input meets spontaneous brain activity’

https://cell.com/trends/neurosciences/fulltext/S0166-2236(24)00153-X

https://nature.com/articles/s41467-024-50102-9

Continue reading “Network mechanisms of ongoing brain activity’s influence on conscious visual perception” »

Researchers at The University of Texas MD Anderson Cancer Center have shown that therapeutically restoring ‘youthful’ levels of a specific subunit of the telomerase enzyme can significantly reduce the signs and symptoms of aging in preclinical models. If these findings are validated in clinical trials, they could have important therapeutic implications for age-related diseases such as Alzheimer’s, Parkinson’s, heart disease, and cancer.

The study, published in Cell, identified a small molecule compound that restores physiological levels of telomerase reverse transcriptase (TERT), which normally is repressed with the onset of aging. Maintenance of TERT levels in aged lab models reduced cellular senescence and tissue inflammation, spurred new neuron formation with improved memory, and enhanced neuromuscular function, which increased strength and coordination.

The researchers show that TERT functions not only to extend telomeres, but also acts as a transcription factor to affect the expression of many genes directing neurogenesis, learning and memory, cellular senescence, and inflammation.