Lifeboat Foundation

A worldwide team of senior scientists and clinicians have come together to produce an editorial which indicates that certain microbes — a specific virus and two specific types of bacteria — are major causes of Alzheimer’s Disease. Their paper, which has been published online in the highly regarded peer-reviewed journal, Journal of Alzheimer’s Disease, stresses the urgent need for further research — and more importantly, for clinical trials of anti-microbial and related agents to treat the disease.

This major call for action is based on substantial published evidence into Alzheimer’s. The team’s landmark editorial summarises the abundant data implicating these microbes, but until now this work has been largely ignored or dismissed as controversial — despite the absence of evidence to the contrary. Therefore, proposals for the funding of clinical trials have been refused, despite the fact that over 400 unsuccessful clinical trials for Alzheimer’s based on other concepts were carried out over a recent 10-year period.

Opposition to the microbial concepts resembles the fierce resistance to studies some years ago which showed that viruses cause certain types of cancer, and that a bacterium causes stomach ulcers. Those concepts were ultimately proved valid, leading to successful clinical trials and the subsequent development of appropriate treatments.

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Alzheimer’s may be contagious.

A protein might be capable of spreading Alzheimer’s through blood transfusions and surgical equipment, but we don’t know yet how much of a risk this is.

PROFITABLY recycling waste is always a good idea. And the Allen Institute for Brain Science, in Seattle, has found a way to recycle what is perhaps the most valuable waste of all—living human brain tissue. Understandably, few people are willing to donate parts of their brains to science while they are still alive. But, by collaborating with seven local neurosurgeons, the institute’s chief scientist, Christof Koch, and his colleagues, have managed to round up specimens of healthy tissue removed by those surgeons in order to get to unhealthy parts beyond them, which needed surgical ministration. Normally, such tissue would be disposed of as waste. Instead, Dr Koch is making good use of it.

The repository the cells from these samples end up in is a part of a wider project, the Allen Cell Types Database. The first data from the newly collected human brain cells were released on October 25th. The Allen database, which is open for anyone to search, thus now includes information on the shape, electrical activity and gene activity of individual human neurons. The electrical data are from 300 live neurons of various types, taken from 36 people. The shapes (see picture for example) are from 100 of these neurons. The gene-expression data come from 16,000 neurons, though those cells are post-mortem samples.

The human brain is the most complex object in the known universe. Because it is more complicated than animal brains in ways that (say) human livers are not more complicated than animal livers, using animal brains as analogues of human ones is never going to be satisfactory. Dr Koch’s new database may therefore help explain what is special about human brains. That will assist understanding of brain diseases and disorders. It may also shed light on one of his particular interests, the nature of consciousness.

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Purdue Engineering researchers have developed a system that can show what people are seeing in real-world videos, decoded from their fMRI brain scans — an advanced new form of “mind-reading” technology that could lead to new insights in brain function and to advanced AI systems.

The research builds on previous pioneering research at UC Berkeley’s Gallant Lab, which created a computer program in 2011 that translated fMRI brain-wave patterns into images that loosely mirrored a series of images being viewed.

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The relationship between the mind and the brain is a mystery that is central to how we understand our very existence as sentient beings. Some say the mind is strictly a function of the brain — consciousness is the product of firing neurons. But some strive to scientifically understand the existence of a mind independent of, or at least to some degree separate from, the brain.

The peer-reviewed scientific journal NeuroQuantology brings together neuroscience and quantum physics — an interface that some scientists have used to explore this fundamental relationship between mind and brain.

An article published in the September 2017 edition of NeuroQuantology reviews and expands upon the current theories of consciousness that arise from this meeting of neuroscience and quantum physics.

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There are multiple software options that analyze your genetic data and make recommendations on which supplements you should be taking.

Are you ready to live longer?

Robert C. W. Ettinger’s seminal work, The Prospect Of Immortality, detailed many of the scientific, moral, and economic implications of cryogenically freezing humans for later reanimation. It was after that book was published in 1962 that the idea of freezing one’s body after death began to take hold.

One of the most pressing questions is, even if we’re able to revive a person who has been cryogenically preserved, will the person’s memories and personality remain intact? Ettinger posits that long-term memory is stored in the brain as a long-lasting structural modification. Basically, those memories will remain, even if the brain’s “power is turned off”.

This infographic delves into the mechanics and feasibility of cryonics – a process that thousands of people are betting will give them a second shot at life.

Genome editing technologies have revolutionized biomedical science, providing a fast and easy way to modify genes. However, the technique allowing scientists to carryout the most precise edits, doesn’t work in cells that are no longer dividing — which includes most neurons in the brain. This technology had limited use in brain research, until now. Research Fellow Jun Nishiyama, M.D., Ph.D., Research Scientist, Takayasu Mikuni, M.D., Ph.D., and Scientific Director, Ryohei Yasuda, Ph.D. at the Max Planck Florida Institute for Neuroscience (MPFI) have developed a new tool that, for the first time, allows precise genome editing in mature neurons, opening up vast new possibilities in neuroscience research.

This novel and powerful tool utilizes the newly discovered gene editing technology of CRISPR-Cas9, a viral defense mechanism originally found in bacteria. When placed inside a cell such as a neuron, the CRISPR-Cas9 system acts to damage DNA in a specifically targeted place. The cell then subsequently repairs this damage using predominantly two opposing methods; one being non-homologous end joining (NHEJ), which tends to be error prone, and homology directed repair (HDR), which is very precise and capable of undergoing specified gene insertions. HDR is the more desired method, allowing researchers flexibility to add, modify, or delete genes depending on the intended purpose.

Coaxing cells in the brain to preferentially make use of the HDR DNA repair mechanism has been rather challenging. HDR was originally thought to only be available as a repair route for actively proliferating cells in the body. When precursor brain cells mature into neurons, they are referred to as post-mitotic or nondividing cells, making the mature brain largely inaccessible to HDR — or so researchers previously thought. The team has now shown that it is possible for post-mitotic neurons of the brain to actively undergo HDR, terming the strategy “vSLENDR (viral mediated single-cell labeling of endogenous proteins by CRISPR-Cas9-mediated homology-directed repair).” The critical key to the success of this process is the combined use of CRISPR-Cas9 and a virus.