Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: neuroscience – Page 857

As of June, a total of 31 states and the District of Columbia allow for the use of medical marijuana. Pain is the most common reason people say they need this cannabis and the vast majority of users say that it helps. However, despite the claims of the many individuals who believe that cannabinoids — the chemicals in marijuana — can ease pain, it’s been difficult for scientists to explain why. Researchers published in JAMA Psychiatry now claim to clarify the discrepancy.

In a systematic review and meta-analysis released Wednesday, scientists from Syracuse University explain that while studies can’t currently prove that cannabinoid drugs reduce pain, research does demonstrate that they can help with the experience of feeling pain. An evaluation of 18 studies that included 442 adults revealed that the use of cannabinoid drugs modestly increased people’s threshold for pain and reduced pain’s overall sensation of unpleasantness. This suggests to the researchers that cannabis’ analgesic properties, or ability to relieve pain, affect the mind rather than the body.

“This [result] is especially salient because managing chronic pain is not solely about minimizing pain,” Kevin Boehnke, Ph.D., who was not involved in the study, tells Inverse. Boehnke is currently a part of a University of Michigan study also analyzing the effect of cannabis on chronic pain. “Sleep problems, fatigue, anxiety, depression, and other factors tie into the experience of chronic pain.”

Read more

Since cognitive computing can process massive amounts of data that no human could ever digest and imitate the human brain like no computer system ever has, the technology has amazing potential to amplify our abilities — not replace us — and help us make better, data-driven decisions.

As marketers, we always want to get better. Refining our process and strategy to solve our customers’ problems is our mission. But to understand which tactics actually work and which ones don’t, we usually need to analyze huge sets of complex data.

Data analysis can seem like a tall task, especially if you’re more of a creative marketer. But today, cognitive computing can crunch the numbers for you, helping you make better decisions faster, and hone important aspects of your brand, like brand voice, reporting, and customer support.

Read more

Buck Institute on the elimination of aging diseases for this and further generations:

September is Healthy Aging Month, and here at the Buck Institute for Research on Aging, we are on a mission to end the threat of age-related disease for this and future generations. We believe it is possible for people to enjoy healthy lives at age 95 as much as they do at 25, and to achieve that, we’re seeking a more comprehensive understanding of the biology of aging itself.

Over the last century, average human lifespan has been increasing at a rate of approximately 2 years per decade, primarily due to advancements in antibiotics and other medical treatments, as well as improved public health efforts. The U.S. Census Bureau estimates that by 2035, people over the age of 65 will outnumber people under 18 for the first time in U.S. history. This means that there is an increasing population of older adults who suffer in the later years of life from chronic diseases including diabetes, neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease, and cancer. While basic scientific research has provided a lot of insight into the causes and potential treatments of individual diseases, the root cause of these and many other chronic diseases is the biological process of aging.

The goal of the Buck Institute and several other aging research groups across the country is to study and understand more about the underlying mechanisms of aging so that we may find new therapeutic targets to help us delay or even eradicate age-related diseases. The results so far are very compelling. By focusing on the biological mechanisms of aging such as cellular senescence (normal cells stop dividing), chronic inflammation, and changes in metabolism, scientists have been able to extend the disease-free lifespan of laboratory model organisms including flies, worms, and mice. The challenge now is to translate these discoveries into the clinic and determine the best preventative practices to maintain health throughout our lifetime.

Continue reading “Healthy Aging Month: How we can all live better longer” | >

A diet rich in fiber helps reduce inflammation in murine brains.

According to a new study performed by University of Illinois researchers and published in Frontiers in Immunology, a diet rich in fiber reduces inflammation in aged mice, both in the guts and the brain. This beneficial reduction is due to high levels of butyrate, which result from the fermentation of fiber during digestion [1].

Study abstract

Aging results in chronic systemic inflammation that can alter neuroinflammation of the brain. Specifically, microglia shift to a pro-inflammatory phenotype predisposing them to hyper-activation upon stimulation by peripheral immune signals. It is proposed that certain nutrients can delay brain aging by preventing or reversing microglial hyperactivation. Butyrate, a short chain fatty acid (SCFA) produced primarily by bacterial fermentation of fiber in the colon, has been extensively studied pharmacologically as a histone deacetylase (HDAC) inhibitor, and serves as an attractive therapeutic candidate, as butyrate has also been shown to be anti-inflammatory and improve memory in animal models. In the present study, we demonstrate that butyrate can attenuate pro-inflammatory cytokine expression in microglia in aged mice.

Continue reading “High-Fiber Diet Reduces Brain Inflammation in Older Mice” | >

Alzheimer’s disease (AD) is a neurodegenerative disease with characterization of deficits in progressive memory loss, cognitive and behaviour functions. Mild cognitive impairment (MCI) is a predromal stage of AD, displaying cognitive deficit but neither marked functional impairment nor satisfying established clinical criteria for dementia or probable AD. However, not all MCI patients may eventually progress to AD (progressive MCI, pMCI)https://doi.org/10.1016/j.nicl.2013.10.

(2014)." href="https://www.nature.com/articles/s41598-018-31794-8#ref-CR2" id="ref-link-section-d1856e5935"]2, and some remain unchanged (stable MCI, sMCI), or are recovered from. Therefore, differential diagnosis of MCI types and earlier diagnosis of AD and prediction of disease evolution are difficult

Read more

Playlist Electronic Fusion #158, broadcast on 15 September 2018:

01. Plike — Holmesburg 02. Plike — The Monster Study 03. Plike — Subproject 68 04. Plike — Bluebird 05. Plike — Laboratory 12 (Feat. Digibilly) 06. Alpha Wave Movement — Herzschlag Des Universums 07. Alpha Wave Movement — Other Worlds 08. Chris Gate — This Is Syndae 09. Moonbooter — Syndae’s Theme (Boot From Moon Mix) 10. Stefan Erbe — GP 11. Arend Westra — Under The Milky Way 12. Broekhuis, Keller & Schönwälder — Frozen Nights 13. AndAWan — Time To Remember (Ft. Irene Makri) 14. Thought Guild — Tetrahedral Anomalies 15. Erik Seifert — ALICE (A Large Ion Collider Experiment) 16. Wolfgang Roth (Wolfproject) & Jens-H. Kruhl (Wiesenberg) — The Light Belongs To You.

Read more