Lifeboat Foundation

A peroxide scavenger nanoparticle reduces systemic inflammation in mouse models.

With 19 million cases per year worldwide, sepsis is one of the most life-threatening conditions in the intensive care unit. However, to date, there is no specific and effective treatment. Oxidative stress has been shown to play a major role in sepsis pathogenesis by altering the systemic immune response to infections, which, in turn, may lead to multiorgan dysfunction and cognitive impairment. Here, Rajendrakumar et al. developed a nanoparticle-based peroxide scavenger treatment for reducing oxidative stress during sepsis.

To produce the nanoassembly, the authors first developed a water-soluble nanoparticle core containing an active peroxide scavenger and a protein that stabilizes the scavenger and improves its biocompatibility. The nanoparticle core was then coated with a polymer material conjugated with mannose to help the final nanoassembly target inflammatory immune cells through the mannose receptor on the immune cell surfaces. The authors first confirmed in cell cultures that the nanoassembly can selectively reduce hydrogen peroxide–mediated free radical production with minimal toxicity. In cultures, immune cells demonstrated enhanced intracellular uptake of the particles and reduced production of inflammatory markers during activation. To demonstrate the therapeutic efficacy in vivo, the authors carried out three sets of animal studies. In the first set, the nanoassembly was shown to reduce locally induced tissue inflammation and prevent inflammatory immune cell infiltration.

Since the 2003 discovery of the single-atom-thick carbon material known as graphene, there has been significant interest in other types of 2-D materials as well.

For the first time, physicists have built a unique topological insulator in which optical and electronic excitations hybridize and flow together. They report their discovery in Nature.

Topological insulators are materials with very special properties. They conduct electricity or light particles only on their surface or edges, not the interior. This unusual characteristic could provide technical innovations, and topological insulators have been the subject of intense global research for several years.

Physicists of Julius-Maximilians-Universität Würzburg (JMU) in Bavaria, Germany, with colleagues from the Technion in Haifa, Israel, and Nanyang Technological University in Singapore have reported their discovery in the journal Nature. The team has built the first “exciton-polariton topological insulator,” a topological insulator operating with both light and electronic excitations simultaneously.

Scientists have discovered new particles that could lie at the heart of a future technological revolution based on photonic circuitry, leading to superfast, light-based computing.

Nothing can go faster than the speed of light in a vacuum. But particles in our Universe can’t even go that fast.

A novel technique that nudges single atoms to switch places within an atomically thin material could bring scientists another step closer to realizing theoretical physicist Richard Feynman’s vision of building tiny machines from the atom up.

Six years ago, the Voyager 1 spacecraft informed scientists that it had become the first man-made object to enter interstellar space. Now, Voyager 2 has begun to return signs that its own exit from the Solar System could be coming soon.

Two of Voyager 2’s instruments have measured an increase in the number of high-energy particles called cosmic rays hitting the spacecraft, according to a NASA release. Scientists think that the heliosphere, the region of particles and magnetic fields under the Sun’s influence, blocks some cosmic rays. An increase in their rate means that the probe could be nearing the heliopause, the heliosphere’s outer boundary.

For the first time, an international team of researchers has used a quantum computer to create artificial life—a simulation of living organisms that scientists can use to understand life at the level of whole populations all the way down to cellular interactions.

With the quantum computer, individual living organisms represented at a microscopic level with superconducting qubits were made to “mate,” interact with their environment, and “die” to model some of the major factors that influence evolution.

The new research, published in Scientific Reports on Thursday, is a breakthrough that may eventually help answer the question of whether the origin of life can be explained by quantum mechanics, a theory of physics that describes the universe in terms of the interactions between subatomic particles.

Continue reading “Researchers Created ‘Quantum Artificial Life’ For the First Time” »

There, engineers are doing something strange. They’re freezing computer chips to 460 degrees Fahrenheit below zero, colder than deep space, to simulate the quantum structure of the universe.

At such extreme temperatures these remarkable chips, called qubits, enable scientists to peer into the complex, uncertain interaction of particles at the atomic level — an unseen world in which seemingly contradictory results can exist simultaneously, a place where simply observing an interaction can change it. Or wreck it altogether.

“Quantum — it’s something weird,” said Mike Mayberry, Intel’s chief technology officer and general manager of Intel Labs.

Continue reading “Intel plots a weird, spooky future in quantum computing” »