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Algorithm precisely quantifies flow of information in complex networks

Networks are systems comprised of two or more connected devices, biological organisms or other components, which typically share information with each other. Understanding how information moves between these connected components, also known as nodes, could help to advance research focusing on numerous topics, ranging from artificial intelligence (AI) to neuroscience.

To measure the directional flow of information in systems, scientists typically rely on a mathematical construct known as transfer entropy, which essentially quantifies the rate at which information is transmitted from one node to another. Yet most strategies for calculating transfer entropy developed so far rely on approximations, which significantly limits their accuracy and reliability.

Researchers at AMOLF, a institute in the Netherlands, recently developed a computational algorithm that can precisely quantify transfer entropy in a wide range of complex networks. Their algorithm, introduced in a paper published in Physical Review Letters, opens new exciting possibilities for the study of information transfer in both biological and engineered networks.

AGI is still a decade away

Reinforcement learning is terrible — but everything else is worse.

Karpathy’s sharpest takes yet on AGI, RL, and the future of learning.

Andrej Karpathy’s vision of AGI isn’t a bang — it’s a gradient descent through human history.

Karpathy on AGI & Superintelligence.

* AGI won’t be a sudden singularity — it will blend into centuries of steady progress (~2% GDP growth).

* Superintelligence is uncertain and likely gradual, not an instant “explosion.”

LLMs Can Get “Brain Rot”!

We propose and test the LLM Brain Rot Hypothesis: continual exposure to junk web text induces lasting cognitive decline in large language models (LLMs). To causally isolate data quality, we run controlled experiments on real Twitter/X corpora, constructing junk and reversely controlled datasets via two orthogonal operationalizations: M1 (engagement degree) and M2 (semantic quality), with matched token scale and training operations across conditions. Contrary to the control group, continual pre-training of 4 LLMs on the junk dataset causes non-trivial declines (Hedges’ $g

Large language models prioritize helpfulness over accuracy in medical contexts, finds study

Large language models (LLMs) can store and recall vast quantities of medical information, but their ability to process this information in rational ways remains variable. A new study led by investigators from Mass General Brigham demonstrated a vulnerability in that LLMs are designed to be sycophantic, or excessively helpful and agreeable, which leads them to overwhelmingly fail to appropriately challenge illogical medical queries despite possessing the information necessary to do so.

Findings, published in npj Digital Medicine, demonstrate that targeted training and fine-tuning can improve LLMs’ abilities to respond to illogical prompts accurately.

“As a community, we need to work on training both patients and clinicians to be safe users of LLMs, and a key part of that is going to be bringing to the surface the types of errors that these models make,” said corresponding author Danielle Bitterman, MD, a faculty member in the Artificial Intelligence in Medicine (AIM) Program and Clinical Lead for Data Science/AI at Mass General Brigham.

Amazon reveals 960 megawatt nuclear power plans to cope with AI demand — Richland, Washington site tapped for deployment of Xe-100 small modular reactors

The Cascade Advanced Energy Facility would use next-gen Xe-100 reactors to deliver 960 megawatts of carbon-free power — but it’s years from becoming reality.

Cyber defense innovation could significantly boost 5G network security

A framework for building tighter security into 5G wireless communications has been created by a Ph.D. student working with the University of Portsmouth’s Artificial Intelligence and Data Center.

With its greater network capacity and ability to rapidly transmit huge amounts of information from one device to another, 5G is a critical component of intelligent systems and services—including those for health care and financial services.

However, the dynamic nature of 5G networks, the high volumes of data shared and the ever changing types of information transmitted means that these networks are extremely vulnerable to cyber threats and increasing risks of attack.

‘Milestone’: Google AI reveals new method to make cancer treatable

In a major leap for cancer research, Google DeepMind and Yale University have unveiled an artificial intelligence system capable of uncovering new biological insights directly validated in living cells.

Announced on October 15, the new foundation model, C2S-Scale 27B, represents one of the largest and most sophisticated AI systems ever developed to study cellular behavior.

Built on Google’s Gemma family of models, it has generated a groundbreaking hypothesis about how cancer cells interact with the immune system—one that could reshape how future therapies are designed.

Smartphone imaging system shows promise for early oral cancer detection in dental clinics

Oral cancer remains a serious health concern, often diagnosed too late for effective treatment, even though the mouth is easily accessible for routine examination. Dentists and dental hygienists are frequently the first to spot suspicious lesions, but many lack the specialized training to distinguish between benign and potentially malignant conditions.

To address this gap, researchers led by Rebecca Richards-Kortum at Rice University have developed and tested a low-cost, smartphone-based imaging system called mDOC (mobile Detection of Oral Cancer). Their recent study, published in Biophotonics Discovery, evaluates how well this system can help dental professionals decide when to refer patients to specialists.

The mDOC device combines and autofluorescence imaging with machine learning to assess oral lesions. Autofluorescence imaging uses to detect changes in tissue fluorescence, which can signal abnormal growth. However, this method alone can be misleading, as benign conditions like inflammation also reduce fluorescence.

From stiff to soft in a snap: Magnetic jamming opens new frontiers for microrobotics

Could tiny magnetic objects, that rapidly clump together and instantly fall apart again, one day perform delicate procedures inside the human body? A new study from researchers at the Max Planck Institute for Intelligent Systems in Stuttgart and at ETH Zurich introduces a wireless method to stiffen and relax small structures using magnetic fields, without wires, pumps, or physical contact.

In music, “jamming” refers to the spontaneous gathering of musicians who often improvise without aiming for a predefined outcome. In physics, jamming describes the transition of a material from a fluid-like to a solid-like state—like a traffic jam, where the flow of cars suddenly stops. This transformation can also be triggered on demand, offering a powerful and versatile way to control stiffness for .

In most robotic applications, jamming is achieved using vacuum systems that suck air out of flexible enclosures filled with materials such as particles, fibers, or grains. But these systems require pumps, valves, and tubing—making them difficult to miniaturize.

Learning the language of lasso peptides to improve peptide engineering

In the hunt for new therapeutics for cancer and infectious diseases, lasso peptides prove to be a catch. Their knot-like structures afford these molecules high stability and diverse biological activities, making them a promising avenue for new therapeutics. To better unleash their clinical potential, a team from the Carl R. Woese Institute for Genomic Biology has developed LassoESM, a new large language model for predicting lasso peptide properties.

The collaborative study was recently published in Nature Communications.

Lasso peptides are made by bacteria. To produce these peptides, bacteria use ribosomes to build chains of amino acids that are then folded by biosynthetic enzymes into a unique slip knot-like structure. Through this process, thousands of different lasso peptides are generated, many of which have demonstrated antibacterial, antiviral, and anticancer properties.

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