Lifeboat Foundation

Chronic anxiety is prevalent and associated with an increased risk of cardiovascular disease. Prior studies that have reported a relationship between muscle sympathetic nerve activity (MSNA) and anxiety have focused on participants with anxiety disorders and/or metabolic syndrome. The present study leverages a large cohort of healthy adults devoid of cardiometabolic disorders to examine the hypothesis that trait anxiety severity is positively associated with resting MSNA and blood pressure. Resting blood pressure (BP) (sphygmomanometer and finger plethysmography), MSNA (microneurography), and heart rate (HR; electrocardiogram) were collected in 88 healthy participants (52 males, 36 females, 25 ± 1 yr, 25 ± 1 kg/m²). Multiple linear regression was performed to assess the independent relationship between trait anxiety, MSNA, resting BP, and HR while controlling for age and sex. Trait anxiety was significantly correlated with systolic arterial pressure (SAP; r = 0.251, P = 0.018), diastolic arterial pressure (DAP; r = 0.291, P = 0.006), mean arterial pressure (MAP; r = 0.328, P = 0.002), MSNA burst frequency (BF; r = 0.237, P = 0.026), and MSNA burst incidence (BI; r = 0.225, P = 0.035). When controlling for the effects of age and sex, trait anxiety was independently associated with SAP (β = 0.206, P = 0.028), DAP (β = 0.317, P = 0.002), MAP (β = 0.325, P = 0.001), MSNA BF (β = 0.227, P = 0.030), and MSNA BI (β = 0.214, P = 0.038). Trait anxiety is associated with increased blood pressure and MSNA, demonstrating an important relationship between anxiety and autonomic blood pressure regulation.

NEW & NOTEWORTHY Anxiety is associated with development of cardiovascular disease. Although the sympathetic nervous system is a likely mediator of this relationship, populations with chronic anxiety have shown little, if any, alteration in resting levels of directly recorded muscle sympathetic nerve activity (MSNA). The present study is the first to reveal an independent relationship between trait anxiety, resting blood pressure, and MSNA in a large cohort of healthy males and females devoid of cardiometabolic comorbidities.

Listen to this article’s corresponding podcast at https://ajpheart.podbean.com/e/anxiety-and-muscle-sympathetic-nerve-activity/.

Functional movement/conversion disorder (FMD), part of the spectrum of Functional Neurological Disorder (FND), is a neuropsychiatric condition marked by a range of neurological symptoms, including tremors, muscular spasms and cognitive difficulties. Despite being the second-most common cause of referrals to neurology outpatient clinics after headache, scientists have struggled to pin down the disorder’s root cause. Female sex and a history of childhood trauma are factors associated with higher risk of developing FMD, but it’s been unclear why.

A new study from investigators of the Brigham and Women’s Hospital, in collaboration with researchers at the National Institute of Neurological Disorders and Stroke, demonstrated that FMD is characterized by epigenetic changes, and that women and childhood abuse survivors with FMD have different epigenetic profiles linked to this condition. Their study, which examined the genomes of over 100 individuals and was recently published in Progress in Neuro-Psychopharmacology and Biological Psychiatry, is the first to demonstrate the occurrence of epigenetic changes in FMD.

“This study finally takes FMD out of a cloud of confusion and provides a neuroscientifically grounded explanation for why childhood trauma and female sex are associated with this disorder,” said lead author Primavera A. Spagnolo, MD, Ph.D., scientific director of the Mary Horrigan Connors Center for Women’s Health and Gender Biology and assistant professor of psychiatry at HMS.

I propose to consider the question, ‘Can machines think?’ This should begin with definitions of the meaning of the terms ‘machine’ and ‘think’. The definitions might be framed so as to reflect so far as possible the normal use of the words, but this attitude is dangerous. If the meaning of the words ‘machine’ and ‘think’ are to be found by examining how they are commonly used it is difficult to escape the conclusion that the meaning and the answer to the question, ‘Can machines think?’ is to be sought in a statistical survey such as a Gallup poll. But this is absurd. Instead of attempting such a definition I shall replace the question by another, which is closely related to it and is expressed in relatively unambiguous words.

The new form of the problem can be described in terms of a game which we call the ‘imitation game’. It is played with three people, a man (A), a woman (B), and an interrogator © who may be of either sex. The interrogator stays in a room apart from the other two. The object of the game for the interrogator is to determine which of the other two is the man and which is the woman. He knows them by labels X and Y, and at the end of the game he says either ‘X is A and Y is B’ or ‘X is B and Y is A’. The interrogator is allowed to put questions to A and B thus:

C: Will X please tell me the length of his or her hair? Now suppose X is actually A, then A must answer. It is A’s object in the game to try and cause C to make the wrong identification. His answer might therefore be.

Female robots are a technological marvel, and many of us could not even tell the difference between a real woman and a female robot. Have you seen female robots such as Harmony and Erica? You cannot spot a distinction to tell that they are robots. But are they created just to satisfy the needs of men?

Have you ever thought of a civilization where human robots rule? Such a situation is not very far away if the current AI trends continue. Experts are expecting such a dramatic change within the mid-2030s. Today we will discuss the scary situation when robots act smarter than humans. An apt movie showing this situation is the 2014 award-winning science fiction movie Ex Machina where the robots become more competent and, in the end, dangerous.

Continue reading “TERRIFYING! Female Robot Too Smart to Only Satisfy Men | Artificial Intelligence News” »

This video gets into two significant reasons why women dread the rise of sexbots. Sex robots are a mystique and a new innovation that will revolutionize how we consider sexual dynamics. Due to today’s gender war and rise of sexless men AI technologies are now hitting the market with a boom. While still overpriced an uncommon here in the U.S the artificial intelligence technogies are sure to make your experience more lifelike.

Links:
(Greater Wisdom Patreon)
https://www.patreon.com/user?u=65975600

Continue reading “Why Women Are Afraid of The Rise of Sexbots” »

My latest Opinion piece:

I possibly cheated on my wife once. Alone in a room, a young woman reached out her hands and seductively groped mine, inviting me to engage and embrace her. I went with it.

Twenty seconds later, I pulled back and ripped off my virtual reality gear. Around me, dozens of tech conference goers were waiting in line to try the same computer program an exhibitor was hosting. I warned colleagues in line this was no game. It created real emotions and challenged norms of partnership and sexuality. But does it really? And who benefits from this?

Continue reading “Don’t Bash Digisexuality. For Some, It Brings Hope” »

Classic Drama Movie: A Boy and His Dog — A young man and his telepathic dog wander through a post-apocalyptic wasteland.

A Boy and His Dog (1975)
Director: L.Q. Jones.
Writers: L.Q. Jones(screenplay), Harlan Ellison(novella), Wayne Cruseturner(uncredited)
Stars: Don Johnson, Jason Robards, Susanne Benton.
Genre: Comedy, Drama, Sci-Fi, Thriller.
Country: United States.
Language: English.
Release Date: March 1975 (USA)
Duration: 86 min.
Filming locations: Coyote Dry Lake, California, USA

Continue reading “A Boy and His Dog | Post-Apocalypse | Don Johnson | Classic Drama Film” »

A method for turning male cells into egg cells in mice could one day be used to help men in a same-sex couple have children who are genetically related to them both.

By Michael Le Page

Brave new world let’s create happiness for everyone by putting microelectrode arrays in our brains but be careful not to create a situation like death by ecstacy by Larry Niven.

In the brain, pleasure is generated by a handful of brain regions called, “hedonic hotspots.” If you were to stimulate these regions directly, you would likely feel pleasurable sensations. However, not all of the hedonic hotspots are the same–some generate the raw sensations of pleasure whereas others are responsible for consciously interpreting and elaborating on the raw pleasure produced by the other hotspots. In this video, in addition to exploring the neuroscience of pleasure, we’ll see how understanding pleasure, happiness, meaning, and purpose can help us live better lives.

Continue reading “PLEASURE GENERATORS in the Brain: The Neuroscience of Pleasure Explained” »