Lifeboat Foundation

Recent studies by Zampaloni et al. and Pahil et al. published in the journal Nature describe a novel method of inhibiting the growth of Gram-negative bacteria such as Acinetobacter using antibiotics consisting of macrocyclic peptides that target the bacterial protein bridge machinery that transports lipopolysaccharides from the cytoplasm to the outer membrane.

The amphipathic lipopolysaccharides in the outer leaflet of the asymmetric outer membrane bilayer of Gram-negative bacteria block antibiotic entry, making the treatment of bacterial infections involving Gram-negative bacteria difficult. Furthermore, the development of antibiotic resistance in bacteria, especially Gram-negative bacteria such as Acinetobacter baumannii, is a rapidly increasing global health concern since antibiotic-resistant bacterial infections are becoming increasingly common among hospitalized and critically ill patients.

The lipopolysaccharide is synthesized inside the bacterial cell in the inner membrane, transported across the cell membrane, and assembled in the outer leaflet. The transportation of lipopolysaccharides occurs with the help of LptB₂FGC, a subcomplex in the inner membrane that enlists adenosine triphosphate (ATP) hydrolysis and a protein bridge to extract lipopolysaccharides from the inner membrane and transport it to the outer membrane. Targeting this transportation complex could effectively inhibit the lipopolysaccharide biosynthesis, making the Gram-negative bacteria susceptible to antibacterial activity.

The Cybertruck has only been out for a month, and in limited numbers, but some Tesla owners are already customizing their vehicles.

New Cybertrucks are getting colored wraps, window tints, and protective coverings. Joe Torbati, the owner of OCDetailing in Fremont, California, told Business Insider he’d received dozens of reachouts after posting a series of YouTube videos showing work he’d done for a new owner on their vehicle.

“We’ve probably been getting about 10 Cybertruck-related emails or contacts per day,” Torbati said. “Though, it’s not the traditional reason you would wrap a car, which would be to protect it — the point of this is more for just aesthetics,” he added.

Tesla is likely to lose its top spot as the leader in electric-vehicle sales, but that doesn’t necessarily mean its losing the EV war.

AUSTIN (Austin Business Journal) — Tesla Inc.’s growing footprint in the Austin area now includes a sizable facility in Hutto. But what it’s for remains unclear.

The Austin Business Journal visited the 36,000-square-foot site at 200 County Road 199 in the fast-growing industrial hub northeast of Austin in late December. The parking lot was full and a nondescript warehouse-style building was bustling with employees in construction vests and helmets, but there were no signs listing any companies and no clear indications of who was occupying it. The only traces it could be Tesla were a handful of the company’s electric vehicle charging stations out front.

But Elon Musk’s EV manufacturing and clean energy company is linked to the site in state filings, and it has been confirmed by Hutto officials. Tesla’s expansion to Hutto underscores the company’s wide-reaching plans for the region — as far south as San Antonio and, now, as far north as Hutto — as it continues buildout of its multibillion-dollar operation in eastern Travis County. The Hutto site is about 30 miles directly north of its gigafactory, which serves as the company’s headquarters, along State Highway 130.

Samsung is planning to release what might be the most advanced cleaning robot yet: a robot vacuum and mopper that will steam clean floors and use AI to detect stains.

The upcoming “Bespoke Jet Bot Combo” cleaner will have a charging base that will auto wash, clean, and dry the robot’s mop pads.

The device will also use AI to detect floor types, objects, and spot stains. When the robot detects a stain, “it goes back to the clean station to heat the mop pads with high-temperature steam and water and then returns to the area,” says a press release on Samsung’s website.

In today’s tech-savvy world, we’re surrounded by mind-blowing AI-powered wonders: voice assistants answering our questions, smart cameras identifying faces, and self-driving cars navigating roads.

Curious about optimizing AI for everyday devices? Dive into the complete overview of MIT’s TinyML and Efficient Deep Learning Computing course. Explore strategies to make AI smarter on small devices. Read the full article for an in-depth look!

The Chinese automaker sold over 3 million clean energy vehicles, with Tesla reporting just 1.35 million in the first three quarters of the year.

Chinese electric vehicle company Build Your Dreams (BYD) is set to become the largest EV maker in 2023, overtaking Tesla for the second year in a row.

Continue reading “The Transformative Potential of AGI — and When It Might Arrive” »

This time of year, temperatures in the region can drop to-40 degrees Fahrenheit.

The viral story of a Russian passenger plane of Polar Airlines Antonov AN-24 landing on a frozen river has now become an icy reality.

Of the world’s various weather phenomena, fog is perhaps the most mysterious, forming and dissipating near the ground with fluctuations in air temperature and humidity interacting with the terrain itself.

While fog presents a major hazard to transportation safety, meteorologists have yet to figure out how to forecast it with the precision they have achieved for precipitation, wind and other stormy events.

This is because the physical processes resulting in fog formation are extremely complex, according to Zhaoxia Pu, a professor of atmospheric sciences at the University of Utah.