Current therapies offer limited benefit for patients with previously treated metastatic pancreatic ductal adenocarcinoma (mPDAC). Aberrant activation of the RAS pathway is the key driver of PDAC, with oncogenic RAS mutations present in more than 90% of cases. Daraxonrasib is an oral RAS(ON) multiselective, tri-complex inhibitor of the active guanosine triphosphate–bound state of mutant and wild-type RAS.
Even while listening, the brain attempts to anticipate the next words. This is the conclusion reached by a current study conducted by an interdisciplinary team of researchers led by PD Dr. Patrick Krauss, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), and PD Dr. Achim Schilling, Heidelberg University. The researchers combined three methods: a natural listening situation, high resolution measurements of brain activity, and an AI language model as reference.
The higher the probability of a certain word occurring in the relevant context, the weaker the neural reaction during processing. At the same time, the data indicate a rise in pre-onset activity before the word begins, suggesting the brain works with predictions. The work is published in the journal NeuroImage.
Are humans born with innate grammatical scaffolding, or does language develop on the basis of use and experience? This is a question that is still debated by the various linguistic schools of thought. Recently, powerful AI language models (Large Language Models, LLMs), which process language by predicting subsequent words, have fueled this debate.
Consider the chief difference between living systems and electronics: the first is generally soft and squishy, while the latter is hard and rigid. Now, in work that could impact human-machine interfaces, biocompatible devices, soft robotics, and more, MIT engineers and colleagues have developed a soft, flexible gel that dramatically changes its conductivity upon the application of light.
Enter the growing field of ionotronics, which involves transferring data through ions, or charged molecules. Electronics does the same with electrons. But while the latter is well established, ionotronics is still being developed, with one huge exception: living systems. The cells in our bodies communicate with a variety of ions, from potassium to sodium.
Ionotronics, in turn, can provide a bridge between electronics and biological tissues. Potential applications range from soft wearable technology to human-machine interfaces.
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