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Seven subsets, two fates: mouse γδ T cells in cancer immunity

Mouse γδ T cells in cancer immunity.

Mouse γδ T cells are not all the same; rather, they comprise seven subsets that influence progression in several cancer types.

Antitumor γδ T cell subsets can be tissue-resident or circulating cells, which generally rely on glycolysis for energy production, and they mediate cancer cell death via interferon-gamma or orchestration of antitumor immunity.

Protumor γδ T cell subsets use lipids for energy production, and they promote primary tumor growth and metastasis through the production of interleukin17A to modulate the behavior of myeloid cells sciencenewshighlights ScienceMission https://sciencemission.com/Seven-subsets,-two-fates

The importance of γδ T cells in cancer, as defenders against tumorigenesis, was established more than 2 decades ago. Since that time, research using mouse models of cancer has brought to light a nonuniform view of tumor-associated γδ T cells by providing granularity into the role of individual γδ T cell subsets in specific cancer types. In this review, we discuss data that highlight the unique contributions of Vγ1+, Vγ4+, Vγ5+, Vγ6+, and Vγ7+ cells throughout cancer progression. We delve into their responses to tumors, including both protective and pathogenic functions. We examine how the mechanisms by which these mouse immune cell subsets shape tumor development and spread can be exploited for therapeutic purposes in people with cancer.

Human brain operates near, but not at, the critical point

A recent study published in Physical Review Letters reveals that many widely used signatures of criticality in brain data may be statistical artifacts. They propose a more robust framework that, when applied to whole-brain fMRI data, confirms the brain operates near, but not exactly at, a critical point.

Neuroscientists have long found the idea fascinating—that the brain operates near a “critical point,” a phase transition between stable and chaotic dynamics. Theory suggests this sweet spot enhances computational flexibility, dynamic range, and sensitivity to inputs. Evidence has mounted over the years from neural recordings showing approximate scale invariance and power-law behavior across spatiotemporal scales.

The concept has even influenced AI, particularly reservoir computing, where networks near the “edge of chaos” tend to perform best. However, the field faces a persistent concern: are these criticality signatures intrinsic to the brain’s recurrent dynamics, or do external inputs and data limitations shape them?

New Carbon Nanotube Coating Could Supercharge 6G Technology

Ultrathin nanotube films absorb terahertz waves, boosting 6G performance and enabling advanced shielding and medical applications. Researchers at Skoltech, working with colleagues from KTH Royal Institute of Technology in Sweden, have developed a key technology that could support future 6G commun

Can Humans REALLY Leave Earth? [Interstellar Spaceship]

If you want to know more about the @HP ZBook Ultra G1a Powered by an @AMD Ryzen™ AI MAX Pro 300 Series Processor, click the link below.
https://www.hp.com/us-en/workstations… Projects (Chrysalis, WFP, Sistema Stellare Proximum) https://www.projecthyperion.org/ My Research Booklet https://nollimedia.com/hyperion_bookl… My Merch: https://damilee.com/collections/gear Become a channel producer: https://ko-fi.com/damilee/tiers Music and Stock footage by Artlist (2 additional months free on any annual plan if you use my link): https://bit.ly/3GxTfQ6 Join the Discord Server: / discord JOIN MY NEWSLETTER: https://www.damilee.com/pages/newsletter DESK + ACCESSORIES: Ergonofis Sway Desk https://bit.ly/3W3sHNi Ergonofis Shift Desk https://bit.ly/3YtHzq4 Film Equipment Black Magic PCC 6K PRO: https://amzn.to/3YiAAz6 Insta360 RS ONE http://bit.ly/3HjifLy Sony FX30 https://amzn.to/3gDAqCw Laowa Probe Lens : https://amzn.to/3HOWvIK Sirui Night Walker https://amzn.to/40mVIbZ IPad Pro 13 Inches M4 https://amzn.to/40hH1a1 Hollyland MARS https://amzn.to/41GJKYt Hollyland Lark M2 https://amzn.to/3Xf9QiA Aputure Amaran RGB stick https://amzn.to/3A8gh18 RONIN RS-4 https://amzn.to/4f1o6F0 Small Rig COB lighs https://amzn.to/4fqkPip Edited With Davinci Resolve https://bit.ly/4hgUEMC Book Recommendations: https://damilee.com/pages/recommended… INSTAGRAM — / damileearch TWITTER — / damileearch LINKEDIN — / damilee TIKTOK — / damileearch WHO AM I: I’m Dami, a licensed Architect living in Vancouver, BC. I make videos about architecture, career, and creativity. WEBSITES https://www.damilee.com https://nollimedia.com/ Filmmaking by Raffaele di Nicola Raffaele di Nicola IG @nollistudio Special Thanks @TheNetworkHub Vancouver https://thenetworkhub.ca/ GET IN TOUCH: If you’d like to talk, I’d love to hear from you! Commenting on a video or tweeting @damileearch will be the quickest way to get a response from me, but if your question is very long, feel free to email me at [email protected]. I try my best to respond to the emails, but unfortunately, there just aren’t enough hours in the day! A NOLLISTUDIO/NOLLIMEDIA Production http://www.nollistudio.com @HPInc @AMD #InterstellarTravel #GenerationShip #SpaceArchitecture #SpaceColonization #FutureOfHumanity #SpaceExploration #Megastructures #Architecture #Engineering #SciFi #SpaceDesign #DeepSpace #HumanSpaceflight #SpaceHabitat #AsteroidMining #Interstellar #SpaceSettlement #FutureEngineering #ClosedLoopSystems #SpaceTechnology #ad #AMD #Ryzen #RyzenAI What would it actually take to leave Earth — not for a weekend on the Moon, but forever? This video tests three real generation-ship proposals against five brutal constraints: gravity, radiation, closed-loop life support, cultural continuity across 400 years, and the selection problem — choosing who gets to go. We break down Chrysalis (a 58 km modular ship that sheds stages like a rocket), Proximum (a civilization carved inside an asteroid), and WFP (a self-assembling micro-city based on MIT research). Along the way we confront governance without a homeworld, genetic bottlenecks, generational memory loss, and why shared rituals might matter more than engine specs. The answer isn’t one ship — it’s three radically different philosophies of what it means to be human in deep space.

Hyperion Projects (Chrysalis, WFP, Sistema Stellare Proximum)
https://www.projecthyperion.org/

My Research Booklet.
https://nollimedia.com/hyperion_bookl…

My Merch:
https://damilee.com/collections/gear.

Become a channel producer:
https://ko-fi.com/damilee/tiers.

Music and Stock footage by Artlist (2 additional months free on any annual plan if you use my link):

Continue reading “Can Humans REALLY Leave Earth? [Interstellar Spaceship]” | >

Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas

(Cell Reports 32, 108196; September 29, 2020)

As this paper was originally published on September 29, 2020, Figure 3C showed similar imagery across western blot analyses for αTubulin and pAkt473. This error was caused by an inadvertent swap of two loading control panels of αTubulin and Akt that appeared during figure assembly. The corrected figure can be seen below.

The error and correction thereof do not affect the results or conclusions of the study. The authors apologize for any confusion caused.

CPSF73 activation and 3′ RNA polymerase II pausing are lost during readthrough transcription after heat shock

Here, we identified key signatures of transcriptional termination mechanisms that are altered by heat shock, enabling global readthrough of the 3′ends of mRNA genes. The Pol II 3′ pause is lost, CTD phosphorylation at Ser2 and Tyr1 changes, and endonucleolytic cleavage of the transcript is impaired, which is relieved by expression of RBBP6, a cleavage activator. Our data support a multifaceted mechanism of readthrough during stress, whereby changes to both Pol II and the termination machinery trigger transcription to bypass normal termination sites.

The stress-induced readthrough we observed was pervasive, with 85% of the analyzable genes showing downstream transcription after heat shock. There was no correlation with the level of transcription or activation/repression and no indication of any gene class specificity. Prior work has shown that genes with readthrough are largely overlapping between types of cellular stress.19 Moreover, only loose correlations have been found between sequence markers for termination, such as the strength of the PAS and/or flanking GA-rich regions, and readthrough transcription.26 Distinguishing characteristics of readthrough susceptibility for any given stress remain to be elucidated.

Our Pol II ChIP-seq data show that heat shock induces global loss of 3′ Pol II pausing. This occurred at genes with and without readthrough, indicating that lack of Pol II pausing is not sufficient to cause readthrough. This raises interesting questions about the relationship between Pol II deceleration and transcription termination mechanisms. Current models suggest the slowing of Pol II helps the 5′-to-3′ exonuclease XRN2 to degrade the nascent RNA, catch up to transcribing Pol II, and trigger the dissociation of the polymerase from the DNA.9,10,34 This model requires that nascent RNA cleavage occurs to generate the 5′ end for XRN2 to bind. For readthrough genes that retain RNA cleavage during heat shock, the failure of Pol II to decelerate could prevent XRN2 from “catching up,” thereby enabling downstream transcription. For readthrough genes that lose cleavage, Pol II deceleration likely enhances readthrough by having a fast-moving polymerase.

Senescence at the crossroads of postpartum remodeling and tumorigenesis

Cellular senescence has been linked to both beneficial and detrimental functions. Chiche, Djoual, Charifou and colleagues show that senescence supports normal postpartum mammary gland remodeling, but that when oncogenic events coincide with involution, senescent cells enhance tumorigenesis by regulating plasticity, invasion and metastasis.

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