Large language models performed better after full clinical data became available, raising concerns about early triage decision-making.
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Mitochondrial fission helps immune cells kill bacteria and could counter resistance
Alternative therapies that aid the body’s immune system to fight bacteria have shown promise in addressing the global threat of antibiotic resistance. University of Queensland researchers have found when under attack, the body’s immune cells activate a cellular process called mitochondrial fission to kill invading bacteria. Their study is published in the journal Science Immunology.
Dr. James Curson, from UQ’s Institute for Molecular Bioscience, said mitochondrial fission was a critical process in which mitochondria within cells split into smaller units to support the body’s response to stresses, including infections.
“Some bacteria have evolved strategies to stop activation of the mitochondrial fission process—allowing the invading pathogens to survive, and the infection to persist,” Dr. Curson said.
Gene Therapy for Parkinson’s Disease Associated with GBA1 Mutations
Abeliovich et al. make a compelling case for the promise of using gene therapy to treat Parkinson’s disease (PD) patients who possess mutations in the GBA1 gene. People interested in the clinical-translational side of biomedicine should definitely check this out!
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Dyno Therapeutics Launches Two New AAV Capsids and AI Platform for Rare Disease Therapeutic Development at the 2026 American Society of Gene & Cell Therapy (ASGCT) Annual Meeting
Dyno continues to develop impressive new AAV capsids with their AI-guided design approach!
About Dyno Therapeutics.
Dyno Therapeutics is on a mission to build high-performance genetic technologies that transform patients’ lives. Dyno applies AI to build technologies for gene delivery and sequence design that advance “Genetic Agency” — an individual’s ability to take action at the genetic level to live a healthier life — through safe, effective and widely accessible genetic treatments. With frontier AI models and high-throughput in vivo experimentation, Dyno designs optimized AAV delivery vectors that solve gene delivery challenges across a wide range of therapeutic applications including eye, muscle and CNS. Dyno partners across industries to ensure these life-transforming technologies can help as many patients as possible, including through strategic collaborations with leading gene therapy developers Astellas and Roche and with technology companies including NVIDIA. Dyno’s AI-designed capsids are available for direct licensing and through the Dyno Frontiers Network. Visit www.dynotx.com for more information.
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Law of the iterated logarithm
Where “log” is the natural logarithm, “lim sup” denotes the limit superior, and “a.s.” stands for “almost surely”. [ 3 ] [ 4 ]
Another statement given by A. N. Kolmogorov in 1929 [ 2 ] is as follows.
Roles of lysosomal small-molecule transporters in metabolism and signaling
Small-molecule transporters of the lysosomal membrane export lysosomal catabolites for reuse in cell metabolism.
These transporters often show substrate promiscuity and, conversely, a given metabolite is often exported through distinct transport routes and sometimes in different states (e.g., single amino acids versus dipeptides).
Some lysosomal transporters import metabolites into the lumen. The combination of importers and exporters can create small-molecule shuttles across the lysosomal membrane, which regulate the lumen state.
Some lysosomal transporters participate in intracellular signaling cascades. sciencenewshighlights ScienceMission https://sciencemission.com/lysosomal-small-molecule-transporters
Lysosomes degrade damaged or unwanted cell/tissue components and recycle their building blocks through small-molecule transporters of the lysosomal membrane. They also act as signaling hubs that sense and signal internal cues, such as amino acids, to coordinate cell responses. Recently, the activity of several lysosomal metabolite transporters has been elucidated, bringing new insights into lysosomal functions. Cell biological and structural studies of lysosomal transporters have also highlighted their roles in recruiting signaling complexes to lysosomes and delineated how their substrates gate such hybrid transporter/receptor, or ‘transceptor’, function.