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Something Disturbing Happens When You Solve Einstein’s Equations This Way

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Kurt Gödel discovered a solution to General Relativity that allows time travel without any exotic physics, revealing that the theory doesn’t actually guarantee a consistent chain of cause and effect. His “Gödel universe” shows that under certain conditions, the structure of spacetime itself can loop back on itself—blurring the line between past and future and exposing a deep limitation in our understanding of reality.

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The terrifying quantum entanglement theory that breaks reality

What if the most basic assumptions about reality, that objects are separate, and distance is real… are completely wrong? For centuries, classical physics described a predictable, local universe where nothing influenced anything faster than light. Then, quantum entanglement arrived, breaking our entire assumption of reality and terrifying even the most brilliant minds, including Albert Einstein.

00:00 Quantum Entanglement Theory That Breaks Reality.
01:32 The Theory of Quantum Entanglement.
10:58 The Collapse of Local Realism.
20:44 Why Reality Doesn’t Look Quantum.
23:35 The Psychological Consequence of a Nonlocal Reality.

Aperture explores the ideas shaping how we think — philosophy, psychology.
and the hidden forces behind human behavior. New perspectives, every week.

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Human DNA-PKcs promotes broken DNA-end structure independence during NHEJ

Whether DNA-PKcs is necessary for non-homologous end joining has been biochemically obscure. Through optimization of reaction conditions, Fujii and Modesti show that DNA-PKcs plays a constructive role, which leads to indistinguishable repair efficiencies between cohesive-end and blunt-end DNA substrates.

Abstract: Metabolic syndrome and excessive alcohol consumption lead to liver injury and fibrosis, characterized by increased collagen deposition from hepatic stellate cells

https://doi.org/10.1172/JCI197923 Here, David A. Brenner & team discover the RNA-binding protein LARP6 as a master coordinator of hepatic stellate cell activation and fibrosis, using human tissue and liver spheroid models of MASH and MetALD.

The image shows collagen labeling (red) in human liver spheroids MASH model with LARP6-targeting ASO (DAPI, blue). Collagen labeling is decreased compared with MASH control.

11 Center for Epigenomics, UCSD, La Jolla, California, USA.

12 Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.

13 Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida, USA.

Experiments advance efforts to restore vision with transplanted neurons

Researchers at Johns Hopkins Medicine say they have successfully demonstrated that disrupting an eye structure long suspected of blocking the growth and survival of transplanted nerve cells may help restore vision in people with optic nerve damage.

A report on the experiments with animals, stem cells and donated eye tissue was published in Science Translational Medicine. It suggests that altering or removing a thin layer of tissue called the internal limiting membrane, which separates the light-sensing retinal tissue at the back of the eye from the gel-like vitreous fluid that fills the eye, could help transplanted retinal ganglion cells (RGCs) survive and grow in people with blinding optic nerve damage.

Such damage, also known as optic neuropathy, occurs when retinal ganglion cells die of disease, inflammation or injury and stop carrying electrical signals to the brain. Common causes of damage include glaucoma, optic nerve inflammation (optic neuritis) and ischemic optic neuropathy (sudden loss of blood flow to the optic nerve).

Brain scans of 800 incarcerated men link psychopathy to an expanded cortical surface area

A large-scale brain imaging study of over 800 incarcerated men reveals that highly psychopathic individuals possess an expanded cortical surface area and a compressed physical brain organization, offering new clues into the biology of empathy and antisocial behavior.

Neuromodulation for gait disorders

Gait impairments such as freezing, weakness and imbalance remain resistant to standard therapies across neurological disorders. This Review examines advances in neuromodulation, from refining deep brain stimulation to integrating spinal and distributed strategies. It discusses adaptive neurotechnologies, mechanistic insights and a framework for tailoring spatiotemporally precise interventions to restore gait control.

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