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Engineered internal architecture of core-shell lipid nanoparticles promotes efficient mRNA endosomal release

Li et al. show that putting gold nanoparticles inside of LNPs causes marked improvements in endosomal escape efficiency, describe a likely mechanism, and test their complexes with two therapeutic contexts in mice. A simple innovation which could greatly enhance LNP delivery!

Lipid Nanoparticles (LNPs) effectively deliver mRNA to cells but suffer have low levels of endosomal release. Here the authors report on core-shell LNPs with ionizable lipid–coated gold nanoparticle cores with enhanced pH-responsive membrane disruption, endosomal escape, and cytosolic mRNA delivery improving therapeutic efficiency.

Light-powered spaceships could get to our nearest star in 20 years. Fiction? Scientists say it could become fact

That would mean generations upon generations of human lifetimes, all lived out on board a rocket ship travelling across space, in the hope of a comfortable utopia waiting for us when we arrive.

Now, a team of researchers say they’ve demonstrated a form of light-driven propulsion that could one day get us to Alpha Centauri in 20 years.

A team of researchers at the J. Mike Walker ’66 Department of Mechanical Engineering at Texas A&M University say they’ve demonstrated lasers can be used to lift and steer objects without physical contact.

Gerard k. O’neill Was Not Honored as Deserved, so Far… But Maybe It’s Not Too Late!

While doing research during the works of the SRI 4th World Congress, I am trying to deepen my knowledge of the immense work done by Gerard K. O’Neill and his Space Studies Institute (SSI) during the second half of the past century.

Gerry took the work where Tsiolkovsky, Oberth, von Braun, and others had left it, on the great theme of rotating habitats in free space. And more, the SSI, founded by him, has developed an incredible amount of very high-profile studies about space manufacturing [1], covering many aspects of living in free-space habitats. Not only scientific and technical issues. According to the O’Neill teachings—as his main references, like Krafft Ehricke and others, had done—human requirements, attention to life and health protection, human rights, and social needs informed all of the developed studies and conceptual design.

Great outreachers like Isaac Asimov, Arthur Clarke, and Stanley Kubrick were ready to follow O’Neill and promote his concepts in their artworks and in their interviews to TV and media magazines.

A new way to deliver faster, greener wireless connections indoors

Modern life depends on fast and reliable wireless connections. Video calls, streaming services, virtual reality, and smart devices all place growing demands on networks that already serve billions of users. Most wireless data today travels through radio-based technologies such as Wi-Fi and cellular systems.

While these approaches have been highly successful, they face mounting challenges, including crowded radio spectrum, interference in dense indoor spaces, and rising energy consumption as more devices come online.

A promising complementary approach is optical wireless communication, which uses light instead of radio waves to transmit data. Light offers far more bandwidth than radio frequencies, does not interfere with existing wireless systems, and can be directed precisely at specific locations.

Surprise: There was a universe before the Big Bang | Ethan Siegel

“Asking the question of, where did the entire universe come from, is no longer a question for poets and theologians and philosophers. This is a question for scientists, and we have some amazing scientific answers to this question that have defied even the wildest of our expectations.” Subscribe to Big Think on YouTube ► / @bigthink Up next, The mind-blowing circle of life, explained by a biologist ► • The mind-blowing circle of life, explained… Ethan Siegel, theoretical astrophysicist and science communicator, author of the James Webb Space Telescope book, “Infinite Cosmos,” and writer of the science blog, “Starts With A Bang” joins us to explore the cosmic origins of our universe. Read Ethan’s companion article: https://bigthink.com/starts-with-a-ba… — Where did the entire universe come from? 0:57 — A question for scientists 1:43 — The quest for the beginning of the universe 2:21 — Hubble’s telescope 4:09 — Extragalactic objects 5:11 — Blueshifted vs redshifted 6:53 — General theory of relativity 7:50 — The cosmic egg 8:26 — The origin of The Big Bang 9:55 — A cosmological constant 14:24 — Scale invariant spectrum 15:13 — Testing for Cosmic Inflation 19:34 — Our cosmic origins 21:03 — Ethan Siegel, kilt influencer Read the video transcript ► https://bigthink.com/series/the-big-t…

Go Deeper with Big Think: ►Become a Big Think Member Get exclusive access to full interviews, early access to new releases, Big Think merch and more. https://members.bigthink.com/?utm_sou… ►Get Big Think+ for Business Guide, inspire and accelerate leaders at all levels of your company with the biggest minds in business. https://bigthink.com/plus/great-leade…

About Ethan Siegel: Ethan Siegel is a Ph.D. astrophysicist and author of “Starts with a Bang!” He is a science communicator, who professes physics and astronomy at various colleges. He has won numerous awards for science writing since 2008 for his blog, including the award for best science blog by the Institute of Physics. His three books “Treknology: The Science of Star Trek from Tricorders to Warp Drive,” “Beyond the Galaxy: How humanity looked beyond our Milky Way and discovered the entire Universe,” and “Infinite Cosmos: Visions From the James Webb Space Telescope” are available for purchase at Amazon. Follow him on X @startswithabang.

Post-Consciousness Civilizations: Evolving Beyond Human Awareness Extended Edition

What if civilizations outgrow consciousness itself? Explore post-human minds, machine societies, and a future where awareness may no longer be required.

Get Nebula using my link for 50% off an annual subscription: https://go.nebula.tv/isaacarthur.
Watch my exclusive video Settling Saturn’s Rings: https://nebula.tv/videos/isaacarthur–… out Vintage Space: https://nebula.tv/videos/thevintagesp… 🛒 SFIA Merchandise: https://isaac-arthur-shop.fourthwall… 🌐 Visit our Website: http://www.isaacarthur.net ❤️ Support us on Patreon: / isaacarthur ⭐ Support us on Subscribestar: https://www.subscribestar.com/isaac-a… 👥 Facebook Group: / 1,583,992,725,237,264 📣 Reddit Community: / isaacarthur 🐦 Follow on Twitter / X: / isaac_a_arthur 💬 SFIA Discord Server: / discord Credits: Post-Consciousness Civilizations: Evolving Beyond Human Awareness Written, Produced & Narrated by: Isaac Arthur Edited by: Lukas Konecny Select imagery/video supplied by Getty Images Music Courtesy of Epidemic Sound http://epidemicsound.com/creator Sergey Cheremisinov, “Labyrinth” Chris Zabriskie, “Unfoldment, Revealment”, “A New Day in a New Sector”, “Oxygen Garden” Stellardrone, “Red Giant”, “Billions and Billions“
Check out Vintage Space: https://nebula.tv/videos/thevintagesp…

🛒 SFIA Merchandise: https://isaac-arthur-shop.fourthwall…
🌐 Visit our Website: http://www.isaacarthur.net.
❤️ Support us on Patreon: / isaacarthur.
⭐ Support us on Subscribestar: https://www.subscribestar.com/isaac-a…
👥 Facebook Group: / 1583992725237264
📣 Reddit Community: / isaacarthur.
🐦 Follow on Twitter / X: / isaac_a_arthur.
💬 SFIA Discord Server: / discord.
Credits:
Post-Consciousness Civilizations: Evolving Beyond Human Awareness.
Written, Produced & Narrated by: Isaac Arthur.
Edited by: Lukas Konecny.
Select imagery/video supplied by Getty Images.
Music Courtesy of Epidemic Sound http://epidemicsound.com/creator.
Sergey Cheremisinov, \

New Insight into Bone Immunity in Marrow Cavity and Cancellous Bone Microenvironments and Their Regulation

Bone immunity represents a dynamic interface where skeletal homeostasis intersects with systemic immune regulation. We synthesize emerging paradigms by contrasting two functionally distinct microenvironments: the marrow cavity, a hematopoietic and immune cell reservoir, and cancellous bone, a metabolically active hub orchestrating osteoimmune interactions. The marrow cavity not only generates innate and adaptive immune cells but also preserves long-term immune memory through stromal-derived chemokines and survival factors, while cancellous bone regulates bone remodeling via macrophage-osteoclast crosstalk and cytokine gradients. Breakthroughs in lymphatic vasculature identification challenge traditional views, revealing cortical and lymphatic networks in cancellous bone that mediate immune surveillance and pathological processes such as cancer metastasis.

🧠 The Emotional Brain Under Stress: How the Amygdala Connects Chronic Stress to Chronic Disease

We often think of stress as something that just “gets on our nerves,” but what if it’s actually reshaping our brain — and our long-term health?A recent scientific review published in Biomedicine & Pharmacotherapy by Juhyun Song (2023) highlights a fascinating and urgent connection between the brain’s emotional hub — the amygdala — and our rising burden of metabolic diseases, dementia, and mental health disorders. This tiny almond-shaped structure deep in our brain does more than generate fear or

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