Now online! The STED-EC atlas enables inter-organ and multi-time-point comparisons of gene expression in endothelial cells, revealing substantial transcriptomic variations across endothelial cells from different embryonic organs and facilitating investigation of previously unknown molecular mechanisms that govern organ-specific vascular development.
Díaz-Pinés Cort et al. identify a 100-gene inflammation signature and a broader 2,000-gene inflammatome, consistently upregulated across inflammatory diseases and tissues. They show that these resources can detect inflammation in transcriptomic and proteomic datasets, distinguish disease-specific signals from general inflammation, and generate sample-wise inflammation scores correlated with disease activity.
This led to the discovery that myelin swellings have a dynamic character: they can not only grow, but also shrink and even recover completely. It also turns out that the activity of the underlying nerve fibre plays an important role; more activity of the nerve fibre leads to more and bigger swellings, while less activity allows for possible recovery.
The authors show that in human multiple sclerosis tissue, myelin swelling is also dynamic and is prominent around active lesions. Science Mission sciencenewshighlights.
An international research team have gained new insights into the dynamics of myelin swellings in the brain. Myelin swellings are considered as the precursor of lesions in the brain of people with multiple sclerosis (MS). The results have been recently published in the leading magazine Science.
MS is characterised by lesions in the brain and the spinal cord. Aside from these inflammations, damage can also be visible in the myelin; the protective layer surrounding nerve fibers. Myelin swellings are seen as a precursor for damaged myelin.
The research team used advanced microscopy techniques and different models – from zebrafish and mouse models to human brain tissue – to research the formation of this damage.
Analysis of US mortality data from 1990 to 2023 indicates breast cancer, lung cancer, and leukemia deaths decreased in people younger than 50, while ColorectalCancer mortality increased, rising from fifth to first among cancer deaths in this age group.
The majority of cases present at an advanced stage, highlighting the need for increased symptom awareness and earlier screening.
National trends suggest ongoing prevention and early detection strategies are vital for addressing early-onset colorectal cancer.
This study examines changes in cancer mortality in the US for the 5 leading cancer-related deaths among people younger than 50 years over the past 3 decades.
To tackle this challenge, the MATRIX AI Consortium for Human Well-Being at UT San Antonio plans to launch a new initiative that establishes a national hub for “neuromorphic” computing available for public use.
Neuromorphic computing is a revolutionary approach that mimics the human brain’s structure to process information with a fraction of the energy used by traditional computers. Unlike standard processors that crunch data in a fixed sequence, neuromorphic chips operate like biological neurons. They are event-based, meaning that they activate only when there is something new to process, saving energy between events.
The initiative, called THOR: The Neuromorphic Commons, is funded by the National Science Foundation. THOR will make the promising technology available for researchers nationwide to explore and conduct experiments, serving as the largest-ever full-stack neuromorphic platforms to be open to the public.
A study conducted by Penn State University researchers has revealed that organic solar cells could be strengthened by adding a chemical additive, making them suitable for large-scale deployment and manufacturing. The study was reported on the official university website on February 16.
Assistant Professor Nutifafa Doumon and doctoral candidate Souk Yoon “John” Kim, both from the Department of Materials Science and Engineering, led this experiment.