Lifeboat Foundation

SpaceX’s Starlink will be available on most aircraft soon, said Elon Musk. The technology will be available for use by any operator if it is ordered.

Some operators provide an internet connection during airplane flights. However, if you try to use it, you will most likely encounter a problem. The problem with most in-flight internet offerings is speed and connectivity. Airplanes connected to the antenna receive signals from communications towers on the ground as they fly overhead. This limits the availability of internet: it becomes unstable, difficult to connect to, and the actual speed reaches no more than about 10 Mbps. That is why satellite internet can offer a number of benefits, and SpaceX’s Starlink will soon do just that.

Currently, Starlink has a constellation of about 5,000 satellites in low Earth orbit and plans to increase this to 42,000 in the future. This is significantly more than all other companies combined. For example, Viasat, which provides in-flight internet service to JetBlue, United Airlines, and American Airlines, operates a fleet of four satellites, according to The Street.

Controlling the adipo-osteogenic lineage commitment of bone marrow mesenchymal stem cell (BMSC) in favor of osteogenesis is considered a promising approach for bone regeneration and repair. Accumulating evidence indicates that oxidative phosphorylation (OXPHOS) is involved in regulating cell fate decisions. As an essential cofactor for OXPHOS, nicotinamide adenine dinucleotide (NAD) has been shown to correlate with the differentiation of stem cells. However, whether NAD manipulates BMSC lineage commitment through OXPHOS remains elusive. Therefore, it is critical to investigate the potential role of NAD on energy metabolism in mediating BMSC lineage commitment.

In this study, the mitochondrial respiration and intracellular NAD⁺ level were firstly compared between osteogenic and adipogenic cells. For validating the role of NAD in mitochondrial OXPHOS, the inhibitor of NAD⁺ salvage pathway FK866 and activator P7C3 were used to manipulate the NAD⁺ level during osteogenesis. Furthermore, a murine femur fracture model was established to evaluate the effect of FK866 on bone fracture repair.

We elucidated that osteogenic committed BMSCs exhibited increased OXPHOS activity and a decreased glycolysis accompanied by an elevated intracellular NAD⁺ level. In contrast, adipogenic committed BMSCs showed little change in OXPHOS but an upregulated activity in glycolysis and a decline in intracellular NAD⁺ level in vitro. Moreover, attenuates of NAD⁺ via salvage pathway in BMSCs diminished osteogenic commitment due to mitochondria dysfunction and reduced activity of OXPHOS. The cells were rescued by supplementing with nicotinamide mononucleotide. In addition, treatment with NAD⁺ inhibitor FK866 impaired bone fracture healing in vivo.

Ceramic nanowires could essentially be used even for car tires reducing even hazardous rubber waste.

A team of MIT-led engineers found a simple, inexpensive way to strengthen Inconel 718 with ceramic nanowires to be used in metal PBF AM processes. The team believes that their general approach could be used to improve many other materials. “There is always a significant need for the development of more capable materials for extreme environments. We believe that this method has great potential for other materials in the future,” said Ju Li, the Battelle Energy Alliance Professor in Nuclear Engineering and a professor in MIT’s Department of Materials Science and Engineering (DMSE).

Li, who is also affiliated with the Materials Research Laboratory (MRL), is one of three corresponding authors of a paper on the work that appeared in the April 5 issue of Additive Manufacturing. The other corresponding authors are Professor Wen Chen of the University of Massachusetts at Amherst and Professor A. John Hart of the MIT Department of Mechanical Engineering.

Continue reading “MIT researchers develop Inconel 718-ceramic nanowires powder for AM” »

Thanks to directed evolution accelerating natural selection processes, scientists are generating mutants with beneficial properties and improving functionality.

Learn more about these reagents in the new Research Products.

Directed evolution approaches are creating new reagents to help a tried-and-true technique reach new heights.

Continue reading “Directing Superior Reagents for Better PCR Results” »

Patients with advanced/metastatic non–human epidermal growth factor receptor 2 (HER2)-positive gastric/gastroesophageal junction cancer (GC/GEJC) or esophageal adenocarcinoma (EAC) and treated with Opdivo (nivolumab) and chemotherapy maintained their health-related quality of life (HRQoL) “with a reduced risk of definitive deterioration in disease-related and overall health status and without increased treatment-related symptom burden” when compared with patients treated with standalone chemotherapy, according to recent study findings.

Those findings, published in the Journal of Clinical Oncology, “can be helpful when counseling patients with advanced or metastatic GE/GEJC or EAC, providing reassurance that the benefits of adding (Opdivo) to chemotherapy extend not only to improved survival, but also to preservation of their quality of life and prolonged symptom control,” wrote Journal of Clinical Oncology associate editor, Dr. Andrew H. Ko, in a contextual commentary published alongside the study.

Analyzing patient-reported outcomes (PROs) from the phase 3 CheckMate 649 trial, researchers assessed 1,581 participants’ HRQoL via the EQ-5D and Functional Assessment of Cancer Therapy-Gastric (FACT-Ga) scales, including the FACT-General (FACT-G) and Gastric Cancer subscale (GaCS), with the FACT-G GP5 item used to assess treatment-related symptom burden, and studied longitudinal changes in HRQoL measured with mixed models for repeated measures in the PRO analysis population of 1,360 randomly assigned patients, researchers detailed, noting that they also conducted time to symptom or definitive deterioration analyses.

Google built an AI that monitors the amount of idling at intersections to help city planners cut congestion and reduce air pollution. Now it’s working in 70 intersections.

Some asteroids are dense. So dense in fact, that they may contain heavy elements outside of the periodic table, according to a new study on mass density.

The team of physicists from The University of Arizona say they were motivated by the possibility of Compact Ultradense Objects (CUDOs) with a mass density greater than Osmium, the densest naturally occurring, stable element, with its 76 protons.

“In particular, some observed asteroids surpass this mass density threshold. Especially noteworthy is the asteroid 33 Polyhymnia,” the team writes in their study, adding that “since the mass density of asteroid 33 Polyhymnia is far greater than the maximum mass density of familiar atomic matter, it can be classified as a CUDO with an unknown composition.”

🚨 Malicious NuGet package distributing SeroXen RAT targets. NET developers. The malicious user behind this package has released 6 other suspicious packages, with 2.1 million downloads.

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David Baillot.

Aiming to make the process more efficient and convenient, a team of researchers at the University of California San Diego have developed electronic “stickers” that help to measure this phenomenon.