Lifeboat Foundation

In a groundbreaking study published today in Nature, Australian scientists have resolved a long-standing problem in regenerative medicine. Led by Professor Ryan Lister from the Harry Perkins Institute of Medical Research and The University of Western Australia and Professor Jose M Polo from Monash University and the University of Adelaide, the team developed a new method to reprogram human cells to better mimic embryonic stem cells, with significant implications for biomedical and therapeutic uses.

In a revolutionary advance in the mid-2000s, it was discovered that the non-reproductive adult cells of the body, called ‘somatic’ cells, could be artificially reprogrammed into a state that resembles embryonic stem (ES) cells which have the capacity to then generate any cell of the body.

The ability to artificially reprogram human somatic cells, such as skin cells, into these so-called induced pluripotent stem (iPS) cells provided a way to make an essentially unlimited supply of ES-like cells, with widespread applications in disease modelling, drug screening and cell-based therapies.

A protein involved in wound healing can improve learning and memory in ageing mice1.

Platelet factor 4 (PF4) has long been known for its role in promoting blood clotting and sealing broken blood vessels. Now, researchers are wondering whether this signalling molecule could be used to treat age-related cognitive disorders such as Alzheimer’s disease.

“The therapeutic possibilities are very exciting,” says geneticist and anti-ageing scientist David Sinclair at Harvard University in Boston, Massachusetts, who was not involved in the research. The study was published on 16 August in Nature.

Continue reading “Older mouse brains rejuvenated by protein found in young blood” »

Free will?

Neuroscientists and psychologists have been trying for decades to better understand how humans make decisions, in the hope to devise more effective interventions to promote healthy and beneficial lifestyle choices. Two brain regions that have been linked to decision-making are the orbitofrontal cortex (OFC) and the anterior cingulate cortex (ACC).

Researchers at University of California, Berkeley (UC Berkeley), have been conducting extensive research focusing on these two areas of the brain and exploring their involvement in decision-making. In a recent paper published in Nature Neuroscience, they presented interesting new findings that could shed light on the neural processes through which the brain prepares to make choices.

Continue reading “New findings show how the brain prepares to make choices during decision-making” »

The data indicated that circumcision affected most intensely the portions of the victim’s brain associated with reasoning, perception and emotions.

This is a significant development that brings hope to the one billion individuals with obesity worldwide. Researchers led by Director C. Justin LEE from the Center for Cognition and Sociality (CCS) within the Institute for Basic Science (IBS) have discovered new insights into the regulation of fat metabolism. The focus of their study lies within the star-shaped non-neuronal cells in the brain, known as ‘astrocytes’. Furthermore, the group announced successful animal experiments using the newly developed drug ‘KDS2010’, which allowed the mice to successfully achieve weight loss without resorting to dietary restrictions.

The complex balance between food intake and energy expenditure is overseen by the hypothalamus in the brain. While it has been known that the neurons in the lateral hypothalamus are connected to fat tissue and are involved in fat metabolism, their exact role in fat metabolism regulation has remained a mystery. The researchers discovered a cluster of neurons in the hypothalamus that specifically express the receptor for the inhibitory neurotransmitter ‘GABA (Gamma-Aminobutyric Acid)’. This cluster has been found to be associated with the α5 subunit of the GABAA receptor and was hence named the GABRA5 cluster.

In a diet-induced obese mouse model, the researchers observed significant slowing in the pacemaker firing of the GABRA5 neurons. Researchers continued with the study by attempting to inhibit the activity of these GABRA5 neurons using chemogenetic methods. This in turn caused a reduction in heat production (energy consumption) in the brown fat tissue, leading to fat accumulation and weight gain. On the other hand, when the GABRA5 neurons in the hypothalamus were activated, the mice were able to achieve a successful weight reduction. This suggests that the GABRA5 neurons may act as a switch for weight regulation.

A paper published in Nature Communications shows that when neurons are given information about the changing world around them (task-related sensory input) it changes how they behave, putting them on edge so that tiny inputs can then set off ‘avalanches’ of brain activity, supporting a theory known as the critical brain hypothesis.

The researchers, from Cortical Labs and The University of Melbourne, used DishBrain – a collection of 800,000 human neural cells learning to play Pong.

It is the strongest evidence to date in support of a controversial theory of how the human brain processes information.

Continue reading “Brain cells living on the edge” »

In a study of brains from contact sport players who died before reaching 30, more than 40% had chronic traumatic encephalopathy, oXavier?

The findings confirm that CTE can occur even in young people, but more work is needed to determine how CTE relates to clinical symptoms.

Millions of people worldwide get repetitive head impacts through various activities. These can lead to chronic traumatic encephalopathy (CTE), a progressive neurodegenerative disease that causes brain damage similar to that seen in Alzheimer’s disease. CTE has been reported in people as young as 17. The incidence of CTE in young people, however, is unknown.

Continue reading “Chronic traumatic encephalopathy in young athletes” »

HBP researchers have employed highly advanced methods from computing, neuroinformatics and artificial intelligence in a truly integrative approach to understanding the brain as a multi-level system.

The EU-funded Human Brain Project (HBP) comes to an end in September and celebrates its successful conclusion today with a scientific symposium at Forschungszentrum Jülich (FZJ). The HBP was one of the first flagship projects and, with 155 cooperating institutions from 19 countries and a total budget of 607 million euros, one of the largest research projects in Europe. Forschungszentrum Jülich, with its world-leading brain research institute and the Jülich Supercomputing Centre, played an important role in the ten-year project.

“Understanding the complexity of the human brain and explaining its functionality are major challenges of brain research today”, says Astrid Lambrecht, Chair of the Board of Directors of Forschungszentrum Jülich. “The instruments of brain research have developed considerably in the last ten years. The Human Brain Project has been instrumental in driving this development — and not only gained new insights for brain research, but also provided important impulses for information technologies.”

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Now, scientists have a mathematical model that closely matches how the human brain processes visual information.

Scientists have confirmed that human brains are naturally wired to perform advanced calculations, much like a high-powered computer, to make sense of the world through a process known as Bayesian inference.

In a study published in the journal Nature Communications, researchers from the University of Sydney, University of Queensland and University of Cambridge developed a specific mathematical model that closely matches how human brains work when it comes to reading vision. The model contained everything needed to carry out Bayesian inference.