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Technical Advance alert 🙌

https://doi.org/10.1172/jci.insight.

In this Research article, Benjamin D. Philpot & team establish a multimodal dual-reporter mouse that accelerates AngelmanSyndrome therapeutic development through scalable cell-based screening, high-resolution whole-brain mapping, non-invasive live imaging, and sorting neurons with unsilenced paternal Ube3a.

2Animal Models Core.

3Department of Genetics, and.

4Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

The E3-ome gene-centric compendium reveals the human E3 ligase landscape

Now online! The E3-ome defines the human repertoire of ubiquitin E3 ligases, creating a unified resource that maps their diversity across the ubiquitin and ubiquitin-like systems. By consolidating fragmented knowledge, this framework provides a foundation for studying ubiquitin signaling and accelerating discovery.

Spontaneous aging-associated inflammation and genome instability in the immune system of turquoise killifish

Turquoise killifish are naturally short-lived vertebrates that serve as a model system for aging. The authors show that killifish exhibit age-related transformation in the immune system, which rapidly develops inflammation, genome instability and functional decline.

Religion & Spirituality

Dear Lifeboaters! My book ***Why Space? The Purpose of People*** just hit #1 in Astronomy of the Universe on Amazon! Help us keep it there: grab a copy today — or if you already have one, share this post, buy copies for friends and your team, and PLEASE leave a review if you like it. BTW — the KIndle version is FREE with a subscription!

Link to Amazon in comments.

Why Space?: The Purpose of People — Kindle edition by Tumlinson, Rick N
 Religion & Spirituality Kindle eBooks @ Amazon.com.

Painless skin patch offers new way to monitor immune health

Researchers at The Jackson Laboratory (JAX), in collaboration with the Massachusetts Institute of Technology (MIT), have developed the first bandage-like microneedle patch that can sample the body’s immune responses painlessly from the skin. The device detects inflammatory signals within minutes and collects specialized immune cells within hours without the need for blood draws or surgical biopsies.

Already, the patch is helping researchers and clinicians study immune responses in aging and skin autoimmunity, including vitiligo and psoriasis. In the future, it could make it easier to track how people respond to vaccines, infections, and cancer therapies by complementing traditional blood tests and biopsies while being far easier on patients.

The study appears in Nature Biomedical Engineering.

Jupiter’s moons may have formed with the ingredients for life

An international team that included Southwest Research Institute has shown how complex organic molecules (COMs), considered essential chemical precursors to life, may have become part of Jupiter’s four largest moons as they formed. The results appear in companion papers published in The Planetary Science Journal and Monthly Notices of the Royal Astronomical Society. Together, the studies shed new light on how the ingredients for life could have reached the Jovian system.

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