Lifeboat Foundation

Misfolded proteins are toxic to cells. They disrupt normal functions and cause some age-related human degenerative diseases, like Alzheimer’s, Parkinson’s, and Huntington’s diseases. Cells work constantly to eliminate misfolded proteins, but these clearance mechanisms are still poorly understood.

In a new study published April 20 in Nature Cell Biology, researchers at Stanford University discovered a previously unknown cellular pathway for clearing misfolded proteins from the nucleus, the compartment where the cell stores, transcribes, and replicates its DNA. Keeping junk away from those processes is critical to normal cellular function. The new pathway could be a target for age-related disease therapies.

To find the new pathway, researchers in the lab of Judith Frydman, the Donald Kennedy Chair in the School of Humanities and Sciences, integrated several genetic, imaging, and biochemical approaches to understand how yeast cells dealt with misfolded proteins. For the experiments, the team restricted misfolded proteins to either the nucleus or the cytoplasm—the area inside the cell but outside the nucleus. The team visually followed the fate of the misfolded proteins through live-cell imaging and super-resolution microscopy.

NASA landed 12 astronauts on the moon during the Apollo program more than half a century ago. So why is the upcoming Artemis 2 mission just doing a lunary fly-around?

Facebook and Instagram owner Meta will release a commercial A.I. product, following moves from Google, Microsoft, and OpenAI, in 2023 confirmed Reality Labs boss Andrew Bosworth.

This clip is from the Before Skool Podcast ep. # 4 with Rupert Sheldrake. Full podcast can be accessed here: https://www.youtube.com/watch?v=68fjlUuvOGM&t=3784s.

Rupert Sheldrake, PhD, is a biologist and author best known for his hypothesis of morphic resonance. At Cambridge University he worked in developmental biology as a Fellow of Clare College. He was Principal Plant Physiologist at the International Crops Research Institute for the Semi-Arid Tropics in Hyderabad, India. From 2005 to 2010 he was Director of the Perrott-Warrick project for research on unexplained human and animal abilities, administered by Trinity College, Cambridge. Sheldrake has published a number of books — A New Science of Life (1981), The Presence of the Past (1988), The Rebirth of Nature (1991), Seven Experiments That Could Change the World (1994), Dogs That Know When Their Owners are Coming Home (1999), The Sense of Being Stared At (2003), The Science Delusion (Science Set Free) (2012), Science and Spiritual Practices (2017), Ways of Going Beyond and Why They Work (2019).

Continue reading “AI will Not Become Conscious — Rupert Sheldrake” »

This video is from a presentation at a private gathering in San Francisco on March 9th with leading technologists and decision-makers with the ability to influence the future of large-language model AIs. This presentation was given before the launch of GPT-4.

Center for Humane Technology.

Original video : https://vimeo.com/809258916/92b420d98a

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Since its launch in November 2022, ChatGPT, an artificial intelligence (AI) chatbot, has been causing quite a stir because of the software’s surprisingly human and accurate responses.

The auto-generative system reached a record-breaking 100 million monthly active users only two months after launching. However, while its popularity continues to grow, the current discussion within the cybersecurity industry is whether this type of technology will aid in making the internet safer or play right into the hands of those trying to cause chaos.

Enterprise-level network equipment on the secondary market hide sensitive data that hackers could use to breach corporate environments or to obtain customer information.

Looking at several used corporate-grade routers, researchers found that most of them had been improperly wiped during the decommissioning process and then sold online.

Here’s what you need to know about the A-Lab.

Scientists demonstrate a low-power “wake-up” receiver one-tenth the size of other devices.