Lifeboat Foundation

The test came out of DARPA, the U.S. military’s research division, and may be granted an accelerated emergency use authorization by the FDA by the end of the week, according to The Guardian.

If the test works as expected, it could play a major role in preventing future outbreaks by letting people know they need to self-isolate well before they start spreading the coronavirus.

“The concept fills a diagnostic gap worldwide,” Dr. Brad Ringeisen, head of DARPA’s biological technologies office, told The Guardian. He added that, should the FDA approve the test for use, it could be “absolutely a gamechanger.”

Electronic devices which mimic the functionality of biological synapses are a large step to replicate the human brain for neuromorphic computing and for numerous medical research investigations. One of the representative synaptic behaviors is paired-pulse facilitation (PPF). It has been widely investigated because it is regarded to be related to biological memory. However, plasticity behavior is only part of the human brain memory behavior.

Here, we present a phenomenon which is opposite to PPF, i.e., paired-pulse inhibition (PPI), in nano oxide devices for the first time. The research here suggests that rather than being enhanced, the phenomena of memory loss would also be possessed by such electronic devices. The device physics mechanism behind memory loss behavior was investigated. This mechanism is sustained by historical memory and degradation manufactured by device trauma to regulate characteristically stimulated origins of artificial transmission behaviors.

Under the trauma of a memory device, both the signal amplitude and signal time stimulated by a pulse are lower than the first signal stimulated by a previous pulse in the PPF, representing a new scenario in the struggle for memory. In this way, more typical human brain behaviors could be simulated, including the effect of age on latency and error generation, cerebellar infarct, trauma and memory loss pharmacological actions (such as those caused by hyoscines and nitrazepam).

We discuss the state of the art and innovative micro- and nanoscale technologies that are finding niches and opening up new opportunities in medicine, particularly in diagnostic and therapeutic applications. We take the design of point-of-care applications and the capture of circulating tumor cells as illustrative examples of the integration of micro- and nanotechnologies into solutions of diagnostic challenges. We describe several novel nanotechnologies that enable imaging cellular structures and molecular events. In therapeutics, we describe the utilization of micro- and nanotechnologies in applications including drug delivery, tissue engineering, and pharmaceutical development/testing. In addition, we discuss relevant challenges that micro- and nanotechnologies face in achieving cost-effective and widespread clinical implementation as well as forecasted applications of micro- and nanotechnologies in medicine.

Scientists working at Idaho National Laboratory (INL) have announced the approval of a new high-temperature metal after 12 years and a $15 million Department of Energy investment. Alloy 617, a “combination of nickel, chromium, cobalt and molybdenum,” is tolerant and strong at temperatures of more than 1,700 degrees Fahrenheit. The scientists say this means it could be used in existing high temperature nuclear facilities as well as cutting-edge applications like molten salt reactors.

For any new nuclear plant material, making the American Society of Mechanical Engineers (ASME) Boiler and Pressure Vessel Code is like qualifying for the Olympics. Alloy 617 is the first new material to get into “The Code” in 30 years.

KANSAS CITY, Mo. — Thousands of Evergy customers in the metro are without power Monday after strong storms move through the metro.

According to the outage map on Evergy’s website there were 133 active outages at 11:40 a.m., and those 133 outages were impacting 14,296 customers.

There is no word yet on how long it will take crews to fully restore power.

Here’s a new chapter in the story of the miniaturisation of machines: researchers in a laboratory in Singapore have shown that a single atom can function as either an engine or a fridge. Such a device could be engineered into future computers and fuel cells to control energy flows.

“Think about how your computer or laptop has a lot of things inside it that heat up. Today you cool that with a fan that blows air. In nanomachines or quantum computers, small devices that do cooling could be something useful,” says Dario Poletti from the Singapore University of Technology and Design (SUTD).

This work gives new insight into the mechanics of such devices. The work is a collaboration involving researchers at the Centre for Quantum Technologies (CQT) and Department of Physics at the National University of Singapore (NUS), SUTD and at the University of Augsburg in Germany. The results were published in the peer-reviewed journal npj Quantum Information on 1 May.

Antibody found to block infection by the novel coronavirus SARS-CoV-2 in cells.

The ‘47D11’ antibody targets the ‘spike protein’ of the destructive coronavirus.

Continue reading “Antibody prevents the COVID-19 virus from infecting human cells” »

Severe coronavirus disease 2019 (COVID-19) is characterized by pneumonia, lymphopenia, exhausted lymphocytes and a cytokine storm. Significant antibody production is observed; however, whether this is protective or pathogenic remains to be determined. Defining the immunopathological changes in patients with COVID-19 provides potential targets for drug discovery and is important for clinical management. In the short time since SARS-CoV2 emerged, much has been learned about the immunopathology of the infection. Here, Xuetao Cao discusses what these early insights imply for drug discovery and clinical management.

A microbe found in mosquitoes that appears to block malaria could be used to control spread of the disease in humans, according to researchers in Kenya and Britain.

In findings published Monday by the journal Nature Communications, the authors describes finding the microbe, Microsporidia MB, in mosquitoes around Lake Victoria in Africa — and that they could not find a single mosquito with the microbe that also had the malaria parasite.

A possible malaria control approach involves the dissemination in mosquitoes of inherited symbiotic microbes to block Plasmodium transmission. However, in the Anopheles gambiae complex, the primary African vectors of malaria, there are limited reports of inherited symbionts that impair transmission. We show that a vertically transmitted microsporidian symbiont (Microsporidia MB) in the An. gambiae complex can impair Plasmodium transmission. Microsporidia MB is present at moderate prevalence in geographically dispersed populations of An. arabiensis in Kenya, localized to the mosquito midgut and ovaries, and is not associated with significant reductions in adult host fecundity or survival. Field-collected Microsporidia MB infected An. arabiensis tested negative for P. falciparum gametocytes and, on experimental infection with P. falciparum, sporozoites aren’t detected in Microsporidia MB infected mosquitoes. As a microbe that impairs Plasmodium transmission that is non-virulent and vertically transmitted, Microsporidia MB could be investigated as a strategy to limit malaria transmission.