Lifeboat Foundation

Blueberries are more than just delicious, these little functional foods have been subject to many studies, and now they have been found to have another beneficial ability attributed to their antioxidant rich portfolio, that is the ability to help reduce the risk of heart disease according to a study published in The American Journal of Clinical Nutrition.

This study found that daily consumption one one cup of blueberries over the course of six months resulted in improved arterial function and cholesterol levels in adults with metabolic syndrome. 138 overweight and obese adults aged 50+ with metabolic syndrome were involved in the double blinded and placebo controlled parallel study.

Metabolic syndrome is a term for a cluster of conditions that includes high blood sugar, high triglycerides, and high blood pressure as well as increasing the risk of developing heart disease and Type 2 diabetes.

Wish you could still be YOU… only younger? Learn how science is turning back time

Part 3 of a series on the mission to defy aging

There it was…in large, bold letters… Turn Back Time.

Full Zoom video of Seeking Delphi™ host Mark Sackler’s interview with Strangeworks CEO, whurley, on the current state of the art in quantum computing.

Progress in research is not linear. Periods characterized by rates of incremental knowledge are interlaced with “eureka” moments as milestone discoveries suddenly open new possibilities that thrust research and knowledge to a higher level. Galileo’s use of the telescope to explore the stars, Kary Mullis’s description of polymerase chain reaction, and Edwin Hubble’s demonstration that the universe is expanding are just few examples of these moments. The field of aging research is living one of those magical moments. Finding a reference metric for the rate of biological aging is key to understanding the molecular nature of the aging process. Defining and validating this metric in humans opens the door to a new kind of medicine that will overcome the limitation of current disease definitions, approaching health in a global perspective and bringing life course preventative measures to the center of attention.

John Giannandrea, Vice President of Engineering with responsibility for Google’s Computer Science Research and Machine Intelligence groups; leading teams in Machine Learning, Machine Intelligence, Computer Perception, Natural Language Understanding, and Quantum Computing, “I’m definitely not worried about the AI apocalypse, I just object to the hype and soundbites that some people are making” said at the TechCrunch Disrupt conference in San Francisco.

Google’s John Giannandrea sits down with Frederic Lardinois to discuss the AI hype/worry cycle and the importance, limitations, and acceleration of machine learning.

Scientists like Prof Sinclair have evidence of speeding up, slowing, and even reversing aging.
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What causes aging? According to Professor David Sinclair, it is a loss of information in our epigenome, the system of proteins like histones and chemical markers like methylation that turn on and off genes. Epigenetics allow different cell types to perform their specific functions — they are what differentiate a brain cell from a skin cell. Our DNA is constantly getting broken, by cosmic rays, UV radiation, free radicals, x-rays and regular cell division etc. When our cells repair that damage, the epigenome is not perfectly reset. And hence over time, noise accumulates in our epigenome. Our cells no longer perform their functions well.

Continue reading “How to Slow Aging (and even reverse it)” »

Facebook can determine where users are even if they opt out of having their whereabouts tracked, the company revealed in a letter sent to US senators.

In the missive, which was widely shared on social media Tuesday, Facebook explained ways it can still figure out where people are after they have selected not to share precise location data with the company.

The social network, which was responding to a request for information by two senators, contended that knowing a user’s whereabouts has benefits ranging from showing ads for nearby shops to fighting hackers and battling misinformation.

Columbia scientists have captured the first images of a new gene editing tool that could improve upon existing CRISPR-based tools. The team developed the tool, called INTEGRATE, after discovering a unique “jumping gene” in Vibrio cholerae bacteria that could insert large genetic payloads in the genome without introducing DNA breaks.

In the new study, published today in Nature, the researchers harnessed a Nobel Prize-winning technique called cryo-electron microscopy to freeze the gene editing complex in action, revealing high-resolution details about how it works.

“We showed in our first study how to leverage INTEGRATE for targeted DNA insertions in bacterial cells,” says Sam Sternberg, Ph.D., assistant professor of biochemistry & molecular biophysics at Columbia University Vagelos College of Physicians and Surgeons, who led the research with Israel Fernandez, Ph.D., assistant professor of biochemistry & molecular biophysics at Columbia. “These new images, a wonderful collaboration with Israel Fernández’s lab, explain the biology with incredible molecular detail and will help us improve the system by guiding protein engineering efforts.”

In laboratory experiments, a metabolic inhibitor was able to kill a variety of human cancer cells of the skin, breast, lung, cervix and soft tissues through a non-apoptotic route—catastrophic macropinocytosis.

In mouse xenograft studies, the inhibitor acted synergistically with a common chemotherapy drug, cyclophosphamide, to reduce tumor growth. Thus macropinocytosis, a rarely described form of cell death, may aid in the treatment of cancer.

“Understanding the signaling pathways underlying macropinocytosis-associated cell death is an important step in developing additional effective strategies to treat neoplasms that are resistant to apoptosis induced by chemotherapy,” said Mohammad Athar, Ph.D., professor in the University of Alabama at Birmingham Department of Dermatology.