Lifeboat Foundation

Intervene Immune is a company focused on the age-related decline of the immune system, which is known as immunosenescence. Here, Bobby Brooke, CEO of Intervene Immune, discusses the clinical potential of regenerating the thymus as a means of reversing age-related immune system decline.

Earlier this year, we hosted the Ending Age-Related Diseases 2018 conference at the Cooper Union, New York City. This was a conference designed to bring together the best in the aging research and biotech investment worlds and saw a range of industry experts sharing their insights.

Continue reading “Bobby Brooke – The Potential of Thymus Regeneration” »

There is a strong correlation between the decline of the immune system and a decrease in future lifespan. As the immune system performs a myriad of functions with a multitude of specialized cell types, its breakdown has serious ramifications for health and longevity. As we age, our immune systems steadily decline, becoming less efficient and more inclined to contribute to chronic inflammation due to inappropriate activation.

This smoldering chronic inflammation, also known as inflammaging, speeds up the development of various age-related diseases due to the crosstalk it has with the various damages of aging. In many ways, inflammaging is the glue that binds these damages together, as each of them has an inflammatory component and their progress is often accelerated in the presence of increased inflammation.

At a basic level, inflammation disrupts tissue maintenance and regeneration by blocking various repair pathways, so when that inflammation is chronic, as is commonly seen in aged individuals, the healing of organs and tissues is poor. Therefore, it is no surprise that chronic inflammation causes most older people to struggle to heal and recover from injury.

Continue reading “The Relationship Between Longevity and Immunity” »

Dr. Barzilai is a chaired Professor of Medicine and Genetics and Director of the biggest Center in the world to study the Biology of Aging.

“Nir is our keynote speaker this year because, quite honestly, if I’d only given him half an hour there is no way he could do justice to his role in our movement. His scientific contributions have been world-leading for decades, but in recent years he has done so much more: he has taken a prominent role in two important rejuvenation startups, and he has also employed his exceptional political skills in forging invaluable new understandings between the biomedical gerontology and regulatory communities. Plus, he’s almost as entertaining a speaker as me!”, says Aubrey de Grey.

Yaron Fuchs is the 2018 grand prize winner of the Sartorius & Science Prize for Regenerative Medicine & Cell Therapy, for work that reveals a role for programmed stem cell death in wound healing and tissue regeneration. The findings, described in his prize-winning essay, “The therapeutic promise of apoptosis,” could potentially pave the way to novel regenerative medicine and tumor therapies that target stem cells undergoing apoptosis — a type of programmed cell death.

The 2018 grand prize winner revealed a role for programmed stem cell death in wound healing and tissue regeneration, and potentially in tumor therapies.

The authorities said the change was aimed at strengthening the government’s “research-driven development strategy” and “optimising the distribution of funding on science and technology”, while scientists said it meant funding approval would be more stringent.

Researchers say they spend so much time on grant applications that they get no time to do science.

You’re cordially invited to the 1st of a series of blog entries I’m writing on anti-aging research smile

A: “It’s a dynamic system that veers away from its homeostasis (normal equilibrium point): hence a form of slow-progressing illness. Labeling it as ‘natural’ is a surrender to our traditional state of ignorance and powerlessness, which fortunately are beginning to be changed!”

In the wake of the October 29 Indonesian crash of a brand new Boeing 737 MAX 8 that took the lives of 189 passengers, the FAA has issued Emergency Airworthiness Directive (AD) 2018−23−51. The 737 is the most widely flown aircraft in the world, This tragedy opens an important conversation between regulators, operators and pilots.

Lion Air, an experienced 737 operator, was the launch carrier last year for the 737 MAX 8 and the MAX 9 in March. While it will take a long time to analyze the Lion Air 610 accident, the AD points out that current system architecture has created vulnerabilities.

The APOE gene, or the “forgetting gene,” has been proven to influence Alzheimer’s risk. So a team of scientists is exploring the effect of gene therapy on people with the riskiest version of the gene.

If it works, the pay-off could be huge.

Gene therapy involves transplanting specific genetic material into human cells in order to correct genetic problems, and is typically attempted on diseases with a singular cause. Alzheimer’s doesn’t seem to have one singular cause — but since the risk of developing it is so strongly associated with the APOE gene, it’s certainly worth a try.

In the spirit of the progenitor of Budda, Mohammed, and Christ, accept that the purse is a tool of suffering.

This new book by Jim Mellon and Al Chalabi is a layman’s guide to longevity. It investigates the new technologies and explains how to benefit from the life extending technologies both personally and professionally. It helps readers unravel the science, offers ideas on potential investment and reveals the views of the key opinion leaders.