Lifeboat Foundation

Scientists at the Francis Crick Institute have discovered a set of simple rules that determine the precision of CRISPR/Cas9 genome editing in human cells. These rules, published in Molecular Cell, could help to improve the efficiency and safety of genome editing in both the lab and the clinic.

Despite the wide use of the CRISPR system, rational application of the technology has been hindered by the assumption that the outcome of genome editing is unpredictable, resulting in random deletions or insertions of DNA regions at the target site.

Before CRISPR can be safely applied in the clinic, scientists need to make sure that they can reliably predict precisely how DNA will be modified.

Continue reading “Scientists crack the CRISPR code for precise human genome editing” »

It shrinks objects to a thousandth of their original size.

NASA’s OSIRIS-REx probe, which just arrived at the asteroid Bennu last week, has already found lots of hydrated minerals on the space rock, mission team members announced today (Dec. 10).

• Scientists at the University of Brisbane may have found a simple way of detecting the early stages of cancer.
• The method is inexpensive, takes 10 minutes, and can work for all types of cancer.
• The test uses gold particles to detect cancerous DNA.

According to Nature, researchers at the University of Brisbane may have developed a simple test that’s able to detect the early stages of cancer.

Not only that but the method is inexpensive, takes a mere 10 minutes, and works for all types of cancer — and the central component used for identifying cancer cells is gold particles.

We’re taught at school that energy can’t be created, merely converted from one form to another. But at the birth of the Universe – that is, everything – the energy needed for the Big Bang must have come from somewhere. Many cosmologists think its origin lies in so-called quantum uncertainty, which is known to allow energy to emerge literally from nowhere. What isn’t clear, however, is why this cosmic energy persisted long enough to drive the Big Bang.

When the Technological Singularity arrives, you can’t even imagine what the future will hold afterwards. Just ask author Vernor Vinge.

A five-time Hugo Award-winning author (among various other awards and accolades), Vernor Vinge has been writing and speculating about AI and intelligence amplification for over half a century. As part of his storied career, an interesting anecdote concerns a rejection letter he received from legendary science fiction editor and publisher John W. Campbell, Jr.

Early in his career, Vinge had proposed a story about a human being with amplified intelligence and (as Vinge relates in his short story collection) Campbell wrote him back with the comment, “Sorry — you can’t write this story. Neither can anyone else.” Jump forward a few decades, and Vinge delivered a paper to NASA entitled The Coming Technological Singularity in which he foresaw a moment when artificial intelligence will develop exponentially until it reached a point that surpasses humanity’s ability to comprehend. It is intelligence so far superior that we can’t even imagine what it would be like. And then what?

Continue reading “Author Vernor Vinge: Proposing a singular view of technology’s future” »

Some patients were even able to indicate that they were happy.

A brain-computer interface records “yes” and “no” answers in patients who lack any voluntary muscle movement.

An MIT team is working on a new aiming system that will allow CubeSats to use lasers for high-bandwidth communications with Earth. The new laser-pointing platform uses a second directional beam to keep the primary data beam on focus, allowing the CubeSat to transmit large amounts of data without the need for heavy antennae or wasting propellant.

Splashdown. Our engineers are testing the airbags to ensure they deploy and keep the spacecraft upright when it splashes into the ocean — even through rough waves or high winds. Dive in: https://go.nasa.gov/2Ek4ttf