Lifeboat Foundation

Study based upon human skeletal muscle aging, mutagenesis, and the role of #satellite cells.

“A more comprehensive understanding of the interplay of stem cell–intrinsic and extrinsic factors will set the stage for improving cell therapies capable of restoring tissue homeostasis and enhancing muscle repair in the aged.”

Human aging has multiple effects on the human body. One of the effects of human aging is the reduction in skeletal muscle (SkM) function and a reduction in the number and activity of satellite cells (SCs), the resident stem cells. The whole genome of single SC clones of the leg muscle vastus lateralis from healthy individuals of different ages (21–78 years) was analyzed, to study the specific connection between SC aging and muscle impairment. In healthy adult muscle rapid increase of SCs is consistent with the accumulation rate of 13 somatic mutations per genome per year. Mutations typically do not happen in SkM-expressed genes because they are protected. However, as mutations in exons and promoters increase, genes involved in SC activity and muscle function are targeted which results in aging. Exons are coding sections of an RNA transcript, or the DNA encoding it, that are translated into protein. Proteins are the synthesis of molecules. A change in of a single base pair that caused the substitution of a different amino acid in the resulting protein (missense mutation) that was propagated to the muscle and detected in association with SC mutations affecting the whole tissue. #Somatic mutagenesis in SCs as a result is the driving force in the age related decline of SkM function.

Continue reading “Human Skeletal Muscle Aging and Mutagenesis” »

In April, Scientists based in Philadelphia unveiled an artificial womb undergoing testing on fetal lambs. With a prediction from one of the researchers that the technology could be ready for human testing in three to five years, artificial wombs suddenly became the most unexpected rage of 2017. But what sort of artificial wombs might realistically be a part of healthcare in the near future?

In this video series, the Galactic Public Archives takes bite-sized looks at a variety of terms, technologies, and ideas that are likely to be prominent in the future. Terms are regularly changing and being redefined with the passing of time. With constant breakthroughs and the development of new technology and other resources, we seek to define what these things are and how they will impact our future.

Follow us on social media:
Twitter / Facebook / Instagram

I have spent the last 30 years in various aspects of the biopharmaceutical industry, which for the most part has been a very rewarding experience.

However, during this time period, having been immersed many different components of therapeutic development and commercialization, one thing has always bothered me: a wide array of promising research never makes it off the bench to see the translational light of day, and gets lost in the historical scientific archives.

I always believed that scientific progress happened in a very linear narrative, with each new discovery supporting the next, resulting ultimately in an eventual stairway of scientific enlightenment.

Continue reading “Death Reversal — The Reanima Project — Research Whose Time Has Come” »

The audio in this archive file was compiled from a 1984 meeting of futurists, transhumanists, and progressives. The main topic of the meeting was the most appropriate ways to engage or advance these philosophies within government. For example, one significant point of discussion centered around whether running for office was an effective way to drive change.

In the course of the discussion, the primary viewpoint FM-2030 espoused was that some aspects of government — especially the concept of leadership — would become obsolete or be replaced by other aspects of society (see Part 1). However, he also expressed what he believed the core of a ‘true’ democracy might look like. This archive file is assembled from excerpts of that section of the discussion.

The audio in this archive file was compiled from a 1984 meeting of futurists, transhumanists & progressives. The main topic of the meeting was the most appropriate ways to engage or advance these philosophies within government. For example, one significant point of discussion centered around whether running for office was an effective way to drive change.

The excerpts in this archive file collect many of futurist FM 2030’s thoughts over the course of the discussion.

About FM 2030: FM 2030 was at various points in his life, an Iranian Olympic basketball player, a diplomat, a university teacher, and a corporate consultant. He developed his views on transhumanism in the 1960s and evolved them over the next thirty-something years. He was placed in cryonic suspension July 8th, 2000.

Continue reading “Open Source SynBio?” »