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Archive for the ‘biotechnology’ tag: Page 7

Apr 20, 2016

Bioquark Inc. and Revita Life Sciences Receive IRB Approval for First-In-Human Brain Death Study

Posted by in categories: aging, bioengineering, biological, biotech/medical, cryonics, disruptive technology, futurism, health, life extension, neuroscience

Bioquark, Inc., (http://www.bioquark.com) a company focused on the development of novel biologics for complex regeneration and disease reversion, and Revita Life Sciences, (http://revitalife.co.in) a biotechnology company focused on translational therapeutic applications of autologous stem cells, have announced that they have received IRB approval for a study focusing on a novel combinatorial approach to clinical intervention in the state of brain death in humans.

This first trial, within the portfolio of Bioquark’s Reanima Project (http://www.reanima.tech) is entitled “Non-randomized, Open-labeled, Interventional, Single Group, Proof of Concept Study With Multi-modality Approach in Cases of Brain Death Due to Traumatic Brain Injury Having Diffuse Axonal Injury” (https://clinicaltrials.gov/ct2/show/NCT02742857?term=bioquark&rank=1), will enroll an initial 20 subjects, and be conducted at Anupam Hospital in Rudrapur, Uttarakhand India.

brainimage

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Mar 21, 2016

Resurrection and Biotechnology

Posted by in categories: biotech/medical, disruptive technology, Elon Musk, futurism, human trajectories, neuroscience, posthumanism, Ray Kurzweil, Skynet, transhumanism

“He is not here; He has risen,” — Matthew 28:6

As billions of Christians around the world are getting ready to celebrate the Easter festival and holiday, we take pause to appreciate the awe inspiring phenomena of resurrection.

crypt

In religious and mythological contexts, in both Western and Eastern societies, well known and less common names appear, such as Attis, Dionysus, Ganesha, Krishna, Lemminkainen, Odin, Osiris, Persephone, Quetzalcoatl, and Tammuz, all of whom were reborn again in the spark of the divine.

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Oct 10, 2015

h+ Magazine: Synthetic Biology — The True Savior of Mankind

Posted by in categories: biological, biotech/medical, disruptive technology, DNA, environmental, ethics, futurism, genetics, health, innovation, science, sustainability, transhumanism

Encapsulation Pictures

Fear of scientists “playing god” is at the centre of many a plot line in science fiction stories. Perhaps the latest popular iteration of the story we all love is Jurassic World (2015), a film I find interesting only for the tribute it paid to the original Michael Crichton novel and movie Jurassic Park.

Full op-ed from h+ Magazine on 7 October 2015 http://hplusmagazine.com/2015/10/07/opinion-synthetic-biolog…f-mankind/

john hammond jurrasic parkIn Jurassic Park, a novel devoted to the scare of genetic engineering when biotech was new in the 1990s, the character of John Hammond says:

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Oct 17, 2014

Alchemy vs Networks: The cure for ageing will come — but it will not be something physical

Posted by in categories: biotech/medical, complex systems, evolution, life extension, transhumanism

Since ancient times people have been searching for the secret of immortality. Their quest has always been, without exception, about a physical item: a fountain, an elixir, an Alchemist’s remedy, a chalice, a pill, an injection of stem cells or a vial containing gene-repairing material. It has never been about an abstract concept.

Our inability to find a physical cure for ageing is explained by a simple fact: We cannot find it because it does not exist. It will never exist.

Those who believe that someday some guy is going to discover a pill or a remedy and give it to people so that we will all live forever are, regrettably, deluded.

I should highlight here that I refer to a cure for the ageing process in general, and not a cure for a specific medical disease. Biotechnology and other physical therapies are useful in alleviating many diseases and ailments, but these therapies will not be the answer to the basic biological process of ageing.

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May 13, 2014

The Transhuman Olympics: Where Entertainment Meets Innovation

Posted by in categories: biotech/medical, evolution, futurism, transhumanism

Since the first modern Olympic Games bowed in Athens in 1896, humanity has gradually integrated the developments of science and technology into the realm of competitive sport.

The various attempts to slow the utilization of advanced materials, pharmaceuticals, biotechnology, and robotics is akin to keeping certain gender or ethnic groups out of the games. Not just discrimination, but impeding the flow of progress.

transhuman olympicsIf the ultimate goal of world-level competition is advancement of human physical ability, then athletes, coaches, physicians, and biotech engineers should be able to choose the very best tactics and strategies to achieve that goal.

A Transhuman Olympics would be wildly entertaining, but would also spur the development of biotechnology at a pace that public and private science could never keep up with. While the ethics of such an event might be hotly contested, the benefits to humankind would be lasting and far reaching.

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Jun 10, 2013

Intimations of Imitations: Visions of Cellular Prosthesis & Functionally-Restorative Medicine

Posted by in categories: biological, biotech/medical, chemistry, engineering, futurism, life extension, nanotechnology, neuroscience

In this essay I argue that technologies and techniques used and developed in the fields of Synthetic Ion Channels and Ion Channel Reconstitution, which have emerged from the fields of supramolecular chemistry and bio-organic chemistry throughout the past 4 decades, can be applied towards the purpose of gradual cellular (and particularly neuronal) replacement to create a new interdisciplinary field that applies such techniques and technologies towards the goal of the indefinite functional restoration of cellular mechanisms and systems, as opposed to their current proposed use of aiding in the elucidation of cellular mechanisms and their underlying principles, and as biosensors.

In earlier essays (see here and here) I identified approaches to the synthesis of non-biological functional equivalents of neuronal components (i.e. ion-channels ion-pumps and membrane sections) and their sectional integration with the existing biological neuron — a sort of “physical” emulation if you will. It has only recently come to my attention that there is an existing field emerging from supramolecular and bio-organic chemistry centered around the design, synthesis, and incorporation/integration of both synthetic/artificial ion channels and artificial bilipid membranes (i.e. lipid bilayer). The potential uses for such channels commonly listed in the literature have nothing to do with life-extension however, and the field is to my knowledge yet to envision the use of replacing our existing neuronal components as they degrade (or before they are able to), rather seeing such uses as aiding in the elucidation of cellular operations and mechanisms and as biosensors. I argue here that the very technologies and techniques that constitute the field (Synthetic Ion-Channels & Ion-Channel/Membrane Reconstitution) can be used towards the purpose of the indefinite-longevity and life-extension through the iterative replacement of cellular constituents (particularly the components comprising our neurons – ion-channels, ion-pumps, sections of bi-lipid membrane, etc.) so as to negate the molecular degradation they would have otherwise eventually undergone.

While I envisioned an electro-mechanical-systems approach in my earlier essays, the field of Synthetic Ion-Channels from the start in the early 70’s applied a molecular approach to the problem of designing molecular systems that produce certain functions according to their chemical composition or structure. Note that this approach corresponds to (or can be categorized under) the passive-physicalist sub-approach of the physicalist-functionalist approach (the broad approach overlying all varieties of physically-embodied, “prosthetic” neuronal functional replication) identified in an earlier essay.

The field of synthetic ion channels is also referred to as ion-channel reconstitution, which designates “the solubilization of the membrane, the isolation of the channel protein from the other membrane constituents and the reintroduction of that protein into some form of artificial membrane system that facilitates the measurement of channel function,” and more broadly denotes “the [general] study of ion channel function and can be used to describe the incorporation of intact membrane vesicles, including the protein of interest, into artificial membrane systems that allow the properties of the channel to be investigated” [1]. The field has been active since the 1970s, with experimental successes in the incorporation of functioning synthetic ion channels into biological bilipid membranes and artificial membranes dissimilar in molecular composition and structure to biological analogues underlying supramolecular interactions, ion selectivity and permeability throughout the 1980’s, 1990’s and 2000’s. The relevant literature suggests that their proposed use has thus far been limited to the elucidation of ion-channel function and operation, the investigation of their functional and biophysical properties, and in lesser degree for the purpose of “in-vitro sensing devices to detect the presence of physiologically-active substances including antiseptics, antibiotics, neurotransmitters, and others” through the “… transduction of bioelectrical and biochemical events into measurable electrical signals” [2].

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Apr 11, 2013

The Life Extension Hubris: Why biotechnology is unlikely to be the answer to ageing

Posted by in categories: biological, biotech/medical, evolution, futurism, homo sapiens, life extension

It is often said that empiricism is one of the most useful concepts in epistemology. Empiricism emphasises the role of experience acquired through one’s own senses and perceptions, and is contrary to, say, idealism where concepts are not derived from experience, but based on ideals.

In the case of radical life extension, there is a tendency to an ‘idealistic trance’ where people blindly expect practical biotechnological developments to be available and applied to the public at large within a few years. More importantly, idealists expect these treatments or therapies to actually be effective and to have a direct and measurable effect upon radical life extension. Here, by ‘radical life extension’ I refer not to healthy longevity (a healthy life until the age of 100–120 years) but to an indefinite lifespan where the rate of age-related mortality is trivial.

Let me mention two empirical examples based on experience and facts:

1. When a technological development depends on technology alone, its progress is often dramatic and exponential.

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