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Archive for the ‘longevity’ tag: Page 14

Jul 14, 2015

The ‘Indispensable Soma’ theory of ageing

Posted by in categories: evolution, health, life extension, science, transhumanism

OK. In scientific terms, it is only a ‘hypothesis’ — the reverse of the ‘Disposable Soma’ theory of ageing. Here how it goes.

For the past several decades, the Disposable Soma theory of ageing has been enjoying good publicity and a lively interest from both academics and the public alike. It stands up to scientific scrutiny, makes conceptual sense and fits well within an evolutionary framework of ageing. The theory basically suggests that, due to energy resource constraints, there is a trade-off between somatic cell and germ cell repair. As a result, germ cells are being repaired effectively and so the survival of the species is assured, at a cost of individual somatic (bodily) ageing and death. To put it very simply, we are disposable, we age and die because all the effective repair mechanisms have been diverted to our germ cell DNA in order to guarantee the survival of our species.

The theory accounts for many repair pathways and mechanisms converging upon the germ cell, and also for many of those mechanisms being driven away from somatic cell repair just to ensure germ cell survival. In the past two or three years however, it is increasingly being realised that this process is not unidirectional (from soma to germ), but it is bi-directional: under certain circumstances, somatic cells may initiate damage that affects germ cells, and also that germ cells may initiate repairs that benefit somatic cells!

I can’t even begin to describe how important this bi-directionality is. Taking this in a wider and more speculative sense, it is, in fact, the basis for the cure of ageing. The discovery that germ cells can (or are forced to) relinquish their repair priorities, and that resources can then be re-allocated for somatic repairs instead, means that we may be able to avoid age-related damage (because this would be repaired with greater fidelity) and, at the same time, avoid overpopulation (as our now damaged genetic material would be unsuitable for reproduction).

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Dec 19, 2013

The Seven Fallacies of Aging

Posted by in categories: biotech/medical, evolution, futurism, life extension, transhumanism

Some people become incredibly confused about the effort to eliminate aging, which they see as a nebulous, ill-defined process. I refer to the concept of radical life extension, when aging as a process has been abolished. I am not referring to simple healthy longevity (the effort to live a healthy life until the current maximum lifespan of 110–120). Here are some common misconceptions:

1. The Fallacy of words

Eliminating aging will make us ‘immortal’ and we will live forever.

No, it won’t. If we eliminate aging as a cause of death, we may be able to live for an indefinite (not infinite) period, until something else kills us. Even in a world without aging, death can happen at any time (at age 10, 65 or 1003) and for any reason (a shot in the head, malaria, drowning). If we manage to eliminate aging as a cause of death, the only certain thing would be that we will not necessarily die when we reach the currently maximum lifespan limit of around 110–120 years. We would certainly NOT live for ever, because something else will kill us sooner or later. Our organs cannot be repaired if we perish in a nuclear explosion for example, or in a fire. Some statisticians have mentioned that, without aging, we may be able to live to 1700–2000 years on average before death happens due to some other catastrophic damage. This is a long time, but it is not ‘forever’.

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Sep 3, 2013

Longevitize!: Essays on the Science, Philosophy & Politics of Longevity

Posted by in categories: biological, biotech/medical, education, ethics, futurism, human trajectories, life extension, lifeboat, media & arts, philosophy, policy

longevitize2013 med

Containing more than 160 essays from over 40 contributors, this edited volume of essays on the science, philosophy and politics of longevity considers the project of ending aging and abolishing involuntary death-by-disease from a variety of viewpoints: scientific, technological, philosophical, pragmatic, artistic. In it you will find not only information on the ways in which science and medicine are bringing about the potential to reverse aging and defeat death within many of our own lifetimes, as well as the ways that you can increase your own longevity today in order to be there for tomorrow’s promise, but also a glimpse at the art, philosophy and politics of longevity as well – areas that will become increasingly important as we realize that advocacy, lobbying and activism can play as large a part in the hastening of progress in indefinite lifespans as science and technology can.

The collection is edited by Franco Cortese. Its contributing authors include William H. Andrews, Ph.D., Rachel Armstrong, Ph.D., Jonathan Betchtel, Yaniv Chen, Clyde DeSouza, Freija van Diujne, Ph.D., John Ellis, Ph.D., Linda Gamble, Roen Horn, the International Longevity Alliance (ILA), Zoltan Istvan, David Kekich (President & C.E.O of Maximum Life Foundation), Randal A. Koene, Ph.D., Maria Konovalenko, M.Sc. (Program Coordinator for the Science for Life Extension Foundation), Marios Kyriazis, MD, M.Sc MIBiol, CBiol (Founder of the ELPIs Foundation for Indefinite Lifespans and the medical advisor for the British Longevity Society), John R. Leonard (Director of Japan Longevity Alliance), Alex Lightman, Movement for Indefinite Life Extension (MILE), Josh Mitteldorf, Ph.D., Tom Mooney (Executive Director of the Coalition to Extend Life), Max More, Ph.D. , B.J. Murphy, Joern Pallensen, Dick Pelletier, Hank Pellissier (Founder of Brighter Brains Institute), Giulio Prisco, Marc Ransford, Jameson Rohrer, Martine Rothblatt, Ph.D., MBA, JD., Peter Rothman (editor-in-chief of H+ Magazine), Giovanni Santostasi, Ph.D (Director of Immortal Life Magazine, Eric Schulke, Jason Silva , R.U. Sirius, Ilia Stambler, Ph.D (activist at the International Longevity Alliance), G. Stolyarov II (editor-in-chief of The Rational Argumentator), Winslow Strong, Jason Sussberg, Violetta Karkucinska, David Westmorland, Peter Wicks, Ph.D, and Jason Xu (director of Longevity Party China and Longevity Party Taiwan).

Available on Amazon today!

Jul 3, 2013

Human Destiny is to Eliminate Death — Essays, Rants & Arguments on Immortalism (Edited Volume)

Posted by in categories: biological, biotech/medical, education, ethics, fun, futurism, human trajectories, life extension, media & arts, neuroscience, philosophy, policy, rants

coveroriginalhankImmortal Life has complied an edited volume of essays, arguments, and debates about Immortalism titled Human Destiny is to Eliminate Death from many esteemed ImmortalLife.info Authors (a good number of whom are also Lifeboat Foundation Advisory Board members as well), such as Martine Rothblatt (Ph.D, MBA, J.D.), Marios Kyriazis (MD, MS.c, MI.Biol, C.Biol.), Maria Konovalenko (M.Sc.), Mike Perry (Ph.D), Dick Pelletier, Khannea Suntzu, David Kekich (Founder & CEO of MaxLife Foundation), Hank Pellissier (Founder of Immortal Life), Eric Schulke & Franco Cortese (the previous Managing Directors of Immortal Life), Gennady Stolyarov II, Jason Xu (Director of Longevity Party China and Longevity Party Taiwan), Teresa Belcher, Joern Pallensen and more. The anthology was edited by Immortal Life Founder & Senior Editor, Hank Pellissier.

This one-of-a-kind collection features ten debates that originated at ImmortalLife.info, plus 36 articles, essays and diatribes by many of IL’s contributors, on topics from nutrition to mind-filing, from teleomeres to “Deathism”, from libertarian life-extending suggestions to religion’s role in RLE to immortalism as a human rights issue.

The book is illustrated with famous paintings on the subject of aging and death, by artists such as Goya, Picasso, Cezanne, Dali, and numerous others.

The book was designed by Wendy Stolyarov; edited by Hank Pellissier; published by the Center for Transhumanity. This edited volume is the first in a series of quarterly anthologies planned by Immortal Life

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Jun 25, 2013

Sexbots, Ethics, and Transhumans

Posted by in categories: ethics, evolution, futurism, media & arts, robotics/AI

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“I zoomed in as she approached the steps of the bridge, taking voyeuristic pleasure in seeing her pixelated cleavage fill the screen.

What was it about those electronic dots that had the power to turn people on? There was nothing real in them, but that never stopped millions of people every day, male and female, from deriving sexual gratification by interacting with those points of light.

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Jun 3, 2013

Lust for life: breaking the 120-year barrier in human ageing

Posted by in categories: biological, biotech/medical, life extension

By Avi Roy, University of Buckingham

In rich countries, more than 80% of the population today will survive past the age of 70. About 150 years ago, only 20% did. In all this while, though, only one person lived beyond the age of 120. This has led experts to believe that there may be a limit to how long humans can live.

Animals display an astounding variety of maximum lifespan ranging from mayflies and gastrotrichs, which live for 2 to 3 days, to giant tortoises and bowhead whales, which can live to 200 years. The record for the longest living animal belongs to the quahog clam, which can live for more than 400 years.

If we look beyond the animal kingdom, among plants the giant sequoia lives past 3000 years, and bristlecone pines reach 5000 years. The record for the longest living plant belongs to the Mediterranean tapeweed, which has been found in a flourishing colony estimated at 100,000 years old.

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Apr 12, 2013

Killing Deathist Cliches: “Death Gives Meaning to Life” is Meaningless!

Posted by in categories: ethics, life extension, philosophy

Le Petit Trépas

One common argument against Radical Life Extension is that a definitive limit to one’s life – that is, death – provides some essential baseline reference, and that it is only in contrast to this limiting factor that life has any meaning at all. In this article I refute the argument’s underlying premises, and then argue that even if such premises were taken as true, its conclusion – that eradicating death would negate the “limiting factor” that legitimizes life — is also invalid.

Death gives meaning to life? No! Death makes life meaningless!

One version of the argument, which I’ve come across in a variety of places, is given in Brian Cooney’s Posthuman, an introductory philosophical text that uses various futurist scenarios and concepts to illustrate the broad currents of Western Philosophy. Towards the end he makes his argument against immortality, claiming that if we had all the time in the universe to do what we wanted, then we wouldn’t do anything at all. Essentially, his argument boils down to ‘if there is no possibility of not being able to do something in the future, then why would we ever do it?”.

This assumes that we make actions on the basis of not being able to do them again. But people don’t make decisions this way. We didn’t go out to dinner because the restaurant was closing down… we went out for dinner because we wanted to go out for dinner… I think that Cooney’s version of the argument is naïve. We don’t make the majority of our decisions by contrasting an action to the possibility of not being able to do it in future.

His argument seems to be that if there were infinite time then we would have no way of prioritizing our actions. If we had a list of all possible actions set before us, and time were limitless, we might (according to his logic) accomplish all the small, negligible things first, because they’re easier and all the hard things can wait. If we had all the time in the world, we would have no reference point with which to judge how important a given action or objective is, which ones it is most important to get done, and which ones should get done in the place of other possibilities. If we really can do every single thing on that listless list, then why bother, if each is as important as every other? In his line-of-reasoning, importance requires scarcity. If we can do everything it were possible to do, then there is nothing that determines one thing as being more important than another. A useful analogy might be that current economic definitions of value require scarcity. If everything were as abundant as everything else, if nothing were scarce, then we would have no way of ascribing economic value to a given thing, such that one thing has more economic value than another. What we sometimes forget is that ecologies aren’t always like economies.

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Apr 7, 2013

4 in 5 Americans Don’t Think That Death Exists?!

Posted by in category: life extension

heaven4 This essay was one of Transhumanity’s biggest hits last month, getting about 1200 hits in its first week, as well as 87 up-votes and 93 comments on Reddit within 2 days. A shortened version is currently the 3rd most-viewed article on ImmortalLife

“Our hope of immortality does not come from any religions, but nearly all religions come from that hope.” — Robert Green Ingersoll

Recent polls indicate that 80% of Americans and over 50% of global citizens believe in an afterlife. I argue that conceptions of death which include or allow for the possibility of an afterlife are not only sufficiently different from conceptions of death devoid of an afterlife as to necessitate that they be given their own term and separate designation, but that such afterlife-inclusive notions of death constitute the very antithesis of afterlife-devoid conceptions of death! Not only are they sufficiently different as to warrant their own separate designations, but afterlife-inclusive conceptions of death miss the very point of death – its sole defining attribute or categorical-qualifier as such. The defining characteristic is not its specific details (e.g. whether physical death counts as death if the mind isn’t physical, as in substance dualism); its defining characteristic is the absence of life and subjectivity. Belief in an afterlife is not only categorically dissimilar but actually antithetical to conceptions of death precluding an afterlife. Thus to believe in heaven is to deny the existence of death!

The fact that their belief involves metaphysical, rather than physical, continuation isn’t a valid counter-argument. To argue via mind-body dualism that the mind is metaphysical, and thus will continue on in a metaphysical realm (i.e. heaven), in this specific case makes no difference. Despite not being physical in such an argument, its relation to the metaphysical realm is the same as the relation of physical objects to the physical realm. It operates according to the “rules” and “causal laws” of the metaphysical realm, and so for all effective purposes can be considered physical in relation thereto, in the same sense that physical objects can be considered physical in relation to physical reality.

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Apr 4, 2013

An Open Letter to Death

Posted by in categories: biological, biotech/medical, homo sapiens, life extension, media & arts

lifebFreedom fironically found in flesh, not knowing whe’er I’m foul or fowl… tickly bound neath trickly form twisting and more unfresh as dawn upon dawn dies in menstrual skyfire like blood made light — a mocking microcosm of my own transubstantiation from rotting viscera to lightstorm infinity?

Just what sick joke is this? To wake and ache and dream and be and become! – and then to die..? To culminate the very universe itself!.. and then to simply die?! For what I ask you! What! Death… what audacious greed! What reckless squander and heedless extravagance!

Guttural red fringed black a bulbous muck death bastphelgmy! We cannot comprehend the sheer stature of death and so hurriedly cover the unknown with a word to hold it in hand and at a distance, to doubt no doubt.

O pallid heavens! O incessant sun undaunted by my barrenaked finitude! O fetid sanctity wet and redragged as the sickly bloom of jagged flesh! O putrid night sky serene despite my spat fury; as I ebb and ember a’roil withinside my sadness unbelieving and hysteric animal heat that vile sun and auster night jaunt their jeer and mock the rude squall of my panicstrewn death nonetheless.

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Nov 13, 2012

The importance of using the correct terms

Posted by in categories: life extension, transparency

Humans have questioned death, and have searched for immortality since they first became conscious of the finiteness of life. Many modern humans are now confident (or at least hopeful) that it may be possible to achieve immortality, perhaps by using technological advances. This is a myth. It is against the laws of physics (think of entropy) for anyone to become immortal, so it will not happen.

Let me clarify what I mean. The term ‘immortal’ literally means someone who never dies, i.e. lives forever. But ‘forever’ means really forever, more than 50 trillion years, until the end of time. In the foreseeable future (the future which is relevant to us alive today) this is just plain nonsense. If the term is nonsense, then it should not be used. Better terms may be ‘longevity’, or ‘extreme lifespan’ which means to live for many years, without stipulating a number. Extreme longevity, or extreme life extension is not immortality. One may be able to live for 1000 years, and then still die. Another suitable term could be ‘indefinite lifespan’ which is the absence of a sustained increase of mortality as a function of age (i.e. it is the absence of death due to aging). These terms denote something feasible, something that can be achieved with the use of near-term future technology.

Another legitimate term to use is ‘Human Biological Immortality’. This is a strict term used in biology to refer to the decrease of the rate of cellular mortality as a function of age. It is, in other words, similar to the term ‘indefinite lifespan’. Here the emphasis is on indefinite, and not on infinite.

I believe that certain humans will be able to live indefinitely (50 years, 500 years, no a priori limit) and that this will happen after a combination of natural evolutionary events (https://acrobat.com/#d=MAgyT1rkdwono-lQL6thBQ) enhanced and accelerated by science and technology (http://hplusmagazine.com/2011/03/04/indefinite-lifespans-a-n…l-brain/). Death by aging will be abolished, and people will only die from accidents, illnesses etc. We will still be mortal.

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