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Jan 25, 2024

Fingerprinting biomolecules with the help of sound

Posted by in categories: materials, nanotechnology

A team of researchers from the Institute for Optoelectronic Systems and Microtechnology at Universidad Politécnica de Madrid (UPM) has designed a biosensor capable of identifying proteins and peptides in quantities as low as a single monolayer. For that, a surface acoustic wave (SAW), a kind of electrically controlled nano earthquake on a chip, is generated with an integrated transducer to act on a stack of 2D materials coated with the biomolecules to be detected.

As they report in the journal Biosensors and Bioelectronics in an article titled “Surface–-driven graphene plasmonic sensor for fingerprinting ultrathin biolayers down to the monolayer limit,” the SAW would ripple the surface of a graphene-based stack in such a way that it confines mid– to very small volumes, enhancing at the nanoscale.

In particular, quasiparticles that are part light (photons) and part matter (electrons and lattice vibrations), called surface plasmon-phonon polaritons, are formed at the rippled stack interplaying strongly with the molecules atop.

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